ARIH2 and RBX1

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (biochemical, pull down)

		ARIH2	RBX1
Description		ariadne RBR E3 ubiquitin protein ligase 2	ring-box 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cul5-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex VCB Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex Site Of DNA Damage
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity NEDD8 Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein-containing Complex Binding Metal Ion Binding Molecular Adaptor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Cullin Family Protein Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Developmental Cell Growth Defense Response To Virus Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Hematopoietic Stem Cell Proliferation Positive Regulation Of Protein Targeting To Mitochondrion	Autophagosome Assembly G1/S Transition Of Mitotic Cell Cycle MAPK Cascade Protein Polyubiquitination Mitophagy Epithelial To Mesenchymal Transition DNA Repair Transcription-coupled Nucleotide-excision Repair Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process DNA Damage Response Response To Oxidative Stress Lysosome Organization Spermatogenesis Regulation Of Mitotic Cell Cycle Insulin Receptor Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Autophagy Protein Ubiquitination Cytokine-mediated Signaling Pathway Protein Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Cellular Response To Insulin Stimulus Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To UV MiRNA-mediated Gene Silencing By MRNA Destabilization P38MAPK Cascade TORC1 Signaling T Cell Activation Signal Transduction In Response To DNA Damage Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Protein Neddylation Positive Regulation Of Translation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Receptor Signaling Pathway Type I Interferon-mediated Signaling Pathway Cellular Response To Chemical Stress Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Cellular Response To Amino Acid Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Base-excision Repair, AP Site Formation Via Deaminated Base Removal Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway RNA Polymerase II Transcription Initiation Surveillance Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Mitophagy Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Autoubiquitination Negative Regulation Of Response To Oxidative Stress Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Recognition of DNA damage by PCNA-containing replication complex Prolactin receptor signaling Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Vif-mediated degradation of APOBEC3G Degradation of beta-catenin by the destruction complex NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Degradation of DVL Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Orc1 removal from chromatin Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Regulation of RUNX2 expression and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Potential therapeutics for SARS Regulation of BACH1 activity Nuclear events stimulated by ALK signaling in cancer KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference ( 28552196) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Ulcerative colitis ( 28067908)	Alcohol use disorder (consumption score) ( 30940813) Allergic rhinitis ( 25085501) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Crohn's disease ( 22936669) LDL cholesterol levels ( 32203549) Neuroticism ( 29255261) Refractive error ( 32231278)
Interacting Genes		57 interacting genes: APOBEC3C APOBEC3F APOBEC3G ARAP1 BUB1 CBR3 CCDC33 CEP126 CKB CRX DCUN1D1 DISC1 DLST DSCAM EEF1A1 EEF1G EIF4E2 EML4 ENSA IL4R KAT5 KCNQ2 MEOX2 NEDD8 OGT PAX6 PHF7 PPP2R1A PTN RBX1 REL RHEB RNF7 RPL8 SCAMP2 SGCE SLC1A6 TP53 TRIM27 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2T UBE2V1 UGP2 USP2-AS1 UTP14A WDR91	78 interacting genes: APP ARIH1 ARIH2 CAND1 CAND2 CCND1 CCNK CDC34 CFLAR COPS4 COPS6 CSNK1E CUL1 CUL3 CUL4A CUL4B CUL5 CUL7 ELOB ELOC ERBIN ERCC8 FBH1 FBXL2 FBXO45 FBXW8 FRZB GHR GLMN GPS1 HAX1 KCTD17 KEAP1 KLHDC2 KLHL22 KLHL3 KPNB1 KRTAP12-2 MAGEC2 MAP3K20 MAP3K7 MAPK8IP2 MKNK2 MYB NEURL2 OS9 PBX4 PML PRAME RHOBTB3 RNF126 RPS6KB1 SERTAD1 SKP1 SMAD3 SNAI1 TAB1 TRIM27 TRIM74 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2F UBE2G1 UBE2G2 UBE2H UBE2L3 UBE2L6 UBE2M UBE2N UBE2R2 VHL VRK2
Entrez ID		10425	9978
HPRD ID		09286	06794
Ensembl ID		ENSG00000177479	ENSG00000100387
Uniprot IDs		O95376 Q53ET9 Q6IBL8	P62877
PDB IDs		7OD1 7ONI	1LDJ 1LDK 1U6G 2HYE 2LGV 3DPL 3DQV 3RTR 4F52 4P5O 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N 6TTU 7B5L 7B5M 7B5N 7B5S 7OKQ 7PLO 7Z8B 7Z8R 7Z8T 7Z8V 7ZBW 7ZBZ 8B3G 8B3I 8CDJ 8CDK 8GQ6 8H33 8H34 8H35 8H36 8H37 8H38 8H3A 8H3F 8H3Q 8H3R 8IJ1 8JAQ 8JAS 8JAV 8JE1 8K9I 8KHP 8OR0 8OR2 8OR3 8OR4 8PQL 8Q7E 8Q7H 8Q7R 8QU8 8R5H 8RHZ 8RWZ 8RX0 8UBU 8WDK 8WQA 8WQB 8WQC 8WQE 8WQF 8WQG 8WQH 9JKB 9KBD
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K48-linked Ubiquitination Protein Monoubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Cytosol Transferase Activity Macromolecule Metabolic Process Protein Modification Process Macromolecule Catabolic Process Protein Metabolic Process Ubiquitin Protein Ligase Binding ISG15 Transferase Activity Proteolysis TOR Signaling Catabolic Process Protein Neddylation ISG15-protein Conjugation DNA Cytosine Deamination TORC1 Signaling Nucleoplasm Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Cytidine To Uridine Editing Cytidine Deaminase Activity DNA Deamination Negative Regulation Of Neuroblast Proliferation Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Regulation Of Neuroblast Proliferation Regulation Of Neural Precursor Cell Proliferation Regulation Of Post-translational Protein Modification Base Conversion Or Substitution Editing Negative Regulation Of Gene Expression Regulation Of TORC1 Signaling Cellular Response To Nutrient Levels Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination UBC13-MMS2 Complex Regulation Of Protein Metabolic Process Ubiquitin-like Protein Transferase Activity Ubiquitin Ligase Complex	Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein Metabolic Process Proteasomal Protein Catabolic Process Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Catabolic Process Ubiquitin-protein Transferase Activity Macromolecule Metabolic Process Cullin-RING Ubiquitin Ligase Complex Protein Monoubiquitination Cytosol Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Scaffold Activity Nucleus Protein K11-linked Ubiquitination Regulation Of Protein Metabolic Process Cul2-RING Ubiquitin Ligase Complex G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stress Ubiquitin-like Protein Transferase Activity Cell Cycle G1/S Phase Transition Cell Cycle Phase Transition Transferase Activity SCF Ubiquitin Ligase Complex Nucleoplasm Cytoplasm Response To Stress Protein K63-linked Ubiquitination Mitotic Cell Cycle Phase Transition Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex ATP Binding Cul3-RING Ubiquitin Ligase Complex Protein Binding Regulation Of Intracellular Signal Transduction SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of TORC1 Signaling
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