ARIH2 and SLC1A6

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARIH2	SLC1A6
Description		ariadne RBR E3 ubiquitin protein ligase 2	solute carrier family 1 member 6
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cul5-RING Ubiquitin Ligase Complex	Golgi Apparatus Plasma Membrane Membrane Presynaptic Membrane Intermediate Filament Cytoskeleton Membrane Protein Complex Glutamatergic Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	L-glutamate Transmembrane Transporter Activity High-affinity L-glutamate Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity Symporter Activity Glutamate:sodium Symporter Activity Metal Ion Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Developmental Cell Growth Defense Response To Virus Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Hematopoietic Stem Cell Proliferation Positive Regulation Of Protein Targeting To Mitochondrion	Neurotransmitter Uptake Monoatomic Ion Transport Neurotransmitter Transport Amino Acid Transport Chemical Synaptic Transmission Neutral Amino Acid Transport Aspartate Transmembrane Transport L-glutamate Transmembrane Transport Regulation Of Membrane Potential Establishment Of Localization In Cell Import Into Cell L-glutamate Import Across Plasma Membrane L-aspartate Import Across Plasma Membrane
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Glutamate Neurotransmitter Release Cycle SLC-mediated transport of amino acids
Drugs			Glutamic acid
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference ( 28552196) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Ulcerative colitis ( 28067908)	Familial squamous cell lung carcinoma ( 29924316)
Interacting Genes		57 interacting genes: APOBEC3C APOBEC3F APOBEC3G ARAP1 BUB1 CBR3 CCDC33 CEP126 CKB CRX DCUN1D1 DISC1 DLST DSCAM EEF1A1 EEF1G EIF4E2 EML4 ENSA IL4R KAT5 KCNQ2 MEOX2 NEDD8 OGT PAX6 PHF7 PPP2R1A PTN RBX1 REL RHEB RNF7 RPL8 SCAMP2 SGCE SLC1A6 TP53 TRIM27 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2T UBE2V1 UGP2 USP2-AS1 UTP14A WDR91	2 interacting genes: ARHGEF11 ARIH2
Entrez ID		10425	6511
HPRD ID		09286	09005
Ensembl ID		ENSG00000177479	ENSG00000105143
Uniprot IDs		O95376 Q53ET9 Q6IBL8	B7Z7Q5 P48664
PDB IDs		7OD1 7ONI
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K48-linked Ubiquitination Protein Monoubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Cytosol Transferase Activity Macromolecule Metabolic Process Protein Modification Process Macromolecule Catabolic Process Protein Metabolic Process Ubiquitin Protein Ligase Binding ISG15 Transferase Activity Proteolysis TOR Signaling Catabolic Process Protein Neddylation ISG15-protein Conjugation DNA Cytosine Deamination TORC1 Signaling Nucleoplasm Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Cytidine To Uridine Editing Cytidine Deaminase Activity DNA Deamination Negative Regulation Of Neuroblast Proliferation Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Regulation Of Neuroblast Proliferation Regulation Of Neural Precursor Cell Proliferation Regulation Of Post-translational Protein Modification Base Conversion Or Substitution Editing Negative Regulation Of Gene Expression Regulation Of TORC1 Signaling Cellular Response To Nutrient Levels Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination UBC13-MMS2 Complex Regulation Of Protein Metabolic Process Ubiquitin-like Protein Transferase Activity Ubiquitin Ligase Complex
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