TRMT61A and TCL1A

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TRMT61A	TCL1A
Name		tRNA methyltransferase 61A	TCL1 family AKT coactivator A
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm TRNA (m1A) Methyltransferase Complex	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol
	Molecular Function	Protein Binding Methyltransferase Activity Transferase Activity MRNA (adenine-N1-)-methyltransferase Activity TRNA (adenine(58)-N1)-methyltransferase Activity	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	RNA Processing MRNA Processing TRNA Processing TRNA Methylation Methylation	Intracellular Signal Transduction
Pathways		tRNA modification in the nucleus and cytosol	None
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Body mass index ( 26426971 ) Brain morphology (MOSTest) ( 32665545 ) Branched-chain amino acid levels (Isoleucine) ( 27898682 ) Extremely high intelligence ( 29520040 ) Hemoglobin levels ( 32327693 ) Intelligence (MTAG) ( 29326435 ) Mean corpuscular volume ( 27863252 32888494 ) Red blood cell count ( 32888494 ) Schizophrenia ( 25056061 )	Adverse response to aromatase inhibitors ( 20876420 ) Mosaic loss of chromosome Y ( 27064253 ) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269 ) Plateletcrit ( 32888494 ) Refractive error ( 32231278 )
Interacting Genes		2 interacting genes: TCL1A TRMT6	37 interacting genes: AKT1 AKT2 AKT3 ATM CADPS CALCOCO2 CARD9 CASP8AP2 CCDC13 CEP55 DDIT4L FLACC1 GOLGA2 H2AC25 INCA1 LNX1 LNX2 LSM3 NFKBIA NFKBID NIF3L1 NTAQ1 PPP1R13B PRTFDC1 REL TAX1BP1 TCF4 TEPSIN TNKS TP53BP2 TRAF1 TRAF2 TRMT61A TTC33 TXLNA TXLNB WDR47
Entrez ID		115708	8115
HPRD ID		08810	01744
Ensembl ID		ENSG00000166166	ENSG00000100721
Uniprot IDs		Q96FX7	P56279
PDB IDs		5CCB 5CCX 5CD1	1JSG
GO Terms Enriched among Interactors		None	Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Apoptotic Signaling Pathway Identical Protein Binding Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Cytoplasm Signaling Adaptor Activity Non-canonical NF-kappaB Signal Transduction Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Toll-like Receptor 4 Signaling Pathway Peptidyl-serine Phosphorylation Negative Regulation Of Fatty Acid Transport Programmed Cell Death Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Cell Death Cell Surface Toll-like Receptor Signaling Pathway Negative Regulation Of Lipid Transport Protein Binding Regulation Of Apoptotic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Syntaxin Binding Regulation Of Programmed Cell Death Thioesterase Binding Cell Surface Pattern Recognition Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Protein Polyubiquitination Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Telomere Capping Myelin Maintenance Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway Mammary Gland Epithelial Cell Differentiation Glycogen Biosynthetic Process Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Glycogen Biosynthetic Process Insulin Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of T-helper 17 Type Immune Response Negative Regulation Of Cell Cycle Response To Muramyl Dipeptide Intracellular Signal Transduction Peptidyl-threonine Phosphorylation Regulation Of Response To Endoplasmic Reticulum Stress Polysaccharide Biosynthetic Process Positive Regulation Of Telomere Maintenance Via Telomerase