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TCL1A and AKT2
Number of citations of the paper that reports this interaction (PubMedID
10983986
)
0
Data Source:
HPRD
(in vitro, in vivo)
TCL1A
AKT2
Description
TCL1 family AKT coactivator A
AKT serine/threonine kinase 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Cytosol
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Early Endosome
Cytosol
Plasma Membrane
Cell Cortex
Membrane
Ruffle Membrane
Molecular Function
Protein Binding
Protein Kinase Binding
Identical Protein Binding
Protein Serine/threonine Kinase Activator Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Molecular Function Activator Activity
Biological Process
Intracellular Signal Transduction
Glycogen Metabolic Process
Glycogen Biosynthetic Process
Glucose Metabolic Process
Regulation Of Translation
Apoptotic Process
Signal Transduction
Insulin Receptor Signaling Pathway
Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane
Positive Regulation Of Glucose Metabolic Process
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Positive Regulation Of Fatty Acid Beta-oxidation
Peripheral Nervous System Myelin Maintenance
Cellular Response To Insulin Stimulus
Intracellular Signal Transduction
Protein Modification Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Fat Cell Differentiation
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of D-glucose Import
Protein Stabilization
Regulation Of Cell Cycle
Mammary Gland Epithelial Cell Differentiation
Cellular Response To High Light Intensity
Protein Localization To Plasma Membrane
Positive Regulation Of Protein Targeting To Membrane
Retinal Rod Cell Apoptotic Process
Positive Regulation Of Cap-dependent Translational Initiation
Negative Regulation Of PERK-mediated Unfolded Protein Response
Positive Regulation Of Cell Motility
Pathways
Activation of BAD and translocation to mitochondria
PIP3 activates AKT signaling
PIP3 activates AKT signaling
Downregulation of ERBB2:ERBB3 signaling
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Activation of AKT2
PDE3B signalling
Inhibition of TSC complex formation by PKB
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
AKT-mediated inactivation of FOXO1A
Deactivation of the beta-catenin transactivating complex
CD28 dependent PI3K/Akt signaling
Co-inhibition by CTLA4
G beta:gamma signalling through PI3Kgamma
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Association with Co-factors
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
RAB GEFs exchange GTP for GDP on RABs
RUNX2 regulates genes involved in cell migration
Regulation of PTEN stability and activity
FLT3 Signaling
Regulation of localization of FOXO transcription factors
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
KEAP1-NFE2L2 pathway
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Regulation of MITF-M-dependent genes involved in pigmentation
Drugs
N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
Diseases
Ovarian cancer
Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy
GWAS
Adverse response to aromatase inhibitors (
20876420
)
Mosaic loss of chromosome Y (
27064253
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
28346444
31624269
)
Plateletcrit (
32888494
)
Refractive error (
32231278
)
Birth weight (
31043758
)
Cerebrospinal fluid t-tau:AB1-42 ratio (
26252872
)
Cerebrospinal T-tau levels (
26252872
)
Diastolic blood pressure (
28739976
)
Lean body mass (
28552196
)
Lymphocyte count (
32888494
)
Interacting Genes
37 interacting genes:
AKT1
AKT2
AKT3
ATM
CADPS
CALCOCO2
CARD9
CASP8AP2
CCDC13
CEP55
DDIT4L
FLACC1
GOLGA2
H2AC25
INCA1
LNX1
LNX2
LSM3
NFKBIA
NFKBID
NIF3L1
NTAQ1
PPP1R13B
PRTFDC1
REL
TAX1BP1
TCF4
TEPSIN
TNKS
TP53BP2
TRAF1
TRAF2
TRMT61A
TTC33
TXLNA
TXLNB
WDR47
43 interacting genes:
ABCG8
AKT1
AKT1S1
APOA1
APOB
APP
APPL1
BLVRA
CCL14
CDKN1A
CHUK
CLIP3
ESR1
FOXO4
FSHR
GSK3B
H3C1
HSP90AA1
MEOX2
MTCP1
NAMPT
PDPK1
PICK1
PIP5K1C
PLEKHO1
PNPLA3
POFUT1
POLR1B
PRKDC
RAB3D
REL
SH3RF1
SLC2A4
SORBS2
SORBS3
SPRR2A
STEAP4
TCL1A
TCL1B
TMED2
TRIB3
TSC2
XIAP
Entrez ID
8115
208
HPRD ID
01744
01262
Ensembl ID
ENSG00000100721
ENSG00000105221
Uniprot IDs
P56279
B4DG79
P31751
PDB IDs
1JSG
1GZK
1GZN
1GZO
1MRV
1MRY
1O6K
1O6L
1P6S
2JDO
2JDR
2UW9
2X39
2XH5
3D0E
3E87
3E88
3E8D
8Q61
9C1W
Enriched GO Terms of Interacting Partners
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Negative Regulation Of PERK-mediated Unfolded Protein Response
Regulation Of PERK-mediated Unfolded Protein Response
Apoptotic Signaling Pathway
Identical Protein Binding
Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane
Cytoplasm
Signaling Adaptor Activity
Non-canonical NF-kappaB Signal Transduction
Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Regulation Of Canonical NF-kappaB Signal Transduction
Apoptotic Process
Toll-like Receptor 4 Signaling Pathway
Peptidyl-serine Phosphorylation
Negative Regulation Of Fatty Acid Transport
Programmed Cell Death
Regulation Of Long-chain Fatty Acid Import Into Cell
Peripheral Nervous System Myelin Maintenance
Cell Death
Cell Surface Toll-like Receptor Signaling Pathway
Negative Regulation Of Lipid Transport
Protein Binding
Regulation Of Apoptotic Process
Negative Regulation Of Response To Endoplasmic Reticulum Stress
Syntaxin Binding
Regulation Of Programmed Cell Death
Thioesterase Binding
Cell Surface Pattern Recognition Receptor Signaling Pathway
Tumor Necrosis Factor-mediated Signaling Pathway
Protein Polyubiquitination
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Telomere Capping
Myelin Maintenance
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Mammary Gland Epithelial Cell Differentiation
Glycogen Biosynthetic Process
Regulation Of Fatty Acid Beta-oxidation
Positive Regulation Of Glycogen Biosynthetic Process
Insulin Receptor Signaling Pathway
Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of T-helper 17 Type Immune Response
Negative Regulation Of Cell Cycle
Response To Muramyl Dipeptide
Intracellular Signal Transduction
Peptidyl-threonine Phosphorylation
Regulation Of Response To Endoplasmic Reticulum Stress
Polysaccharide Biosynthetic Process
Positive Regulation Of Telomere Maintenance Via Telomerase
Intracellular Signal Transduction
Signal Transduction
Regulation Of Intracellular Signal Transduction
Insulin Receptor Signaling Pathway
Cellular Response To Insulin Stimulus
Response To Hormone
Positive Regulation Of Protein Metabolic Process
Regulation Of Signal Transduction
Nitric-oxide Synthase Regulator Activity
Intracellular Signaling Cassette
Regulation Of Innate Immune Response
Cytosol
Regulation Of Cell Communication
Regulation Of Signaling
Cellular Response To Hormone Stimulus
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Toll-like Receptor Signaling Pathway
Response To Insulin
Positive Regulation Of Nitric Oxide Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Signal Transduction
Cellular Response To Peptide Hormone Stimulus
Positive Regulation Of Gene Expression
Positive Regulation Of Metabolic Process
Chemical Homeostasis
Low-density Lipoprotein Particle
Regulation Of Vesicle-mediated Transport
Cellular Response To Oxygen-containing Compound
Cellular Response To Amyloid-beta
Homeostatic Process
Response To Peptide Hormone
Endocytic Vesicle Lumen
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Protein Catabolic Process
Protein Kinase Binding
Regulation Of Nitric Oxide Biosynthetic Process
Very-low-density Lipoprotein Particle
Response To Amyloid-beta
Regulation Of Immune System Process
Response To Stress
Positive Regulation Of Signal Transduction
Regulation Of Nitric Oxide Metabolic Process
Response To Nutrient Levels
Regulation Of Protein Modification Process
Protein Serine/threonine Kinase Binding
Cholesterol Transfer Activity
Regulation Of Defense Response
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