TRMT61A and AHNAK2

Data Source: HiPPIP (Novel)

		TRMT61A	AHNAK2
Name		tRNA methyltransferase 61A	AHNAK nucleoprotein 2
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm TRNA (m1A) Methyltransferase Complex	Nucleus Cytoplasm Cytosol Plasma Membrane T-tubule Sarcolemma
	Molecular Function	Protein Binding Methyltransferase Activity Transferase Activity MRNA (adenine-N1-)-methyltransferase Activity TRNA (adenine(58)-N1)-methyltransferase Activity	Protein Binding
	Biological Process	RNA Processing MRNA Processing TRNA Processing TRNA Methylation Methylation	Regulation Of RNA Splicing
Pathways		tRNA modification in the nucleus and cytosol	None
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Body mass index ( 26426971 ) Brain morphology (MOSTest) ( 32665545 ) Branched-chain amino acid levels (Isoleucine) ( 27898682 ) Extremely high intelligence ( 29520040 ) Hemoglobin levels ( 32327693 ) Intelligence (MTAG) ( 29326435 ) Mean corpuscular volume ( 27863252 32888494 ) Red blood cell count ( 32888494 ) Schizophrenia ( 25056061 )	Cerebrospinal fluid t-tau levels ( 29274321 ) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321 ) Rheumatoid arthritis ( 24390342 30423114 ) Systemic lupus erythematosus ( 26663301 33272962 )
Novel Interactors		8 novel interactors: ADSS1 AHNAK2 CLBA1 COA8 IGHV5-78 PLD4 TDRD9 TMEM121	2 novel interactors: COA8 TRMT61A
Interacting Genes		2 interacting genes: TCL1A TRMT6	16 interacting genes: ABLIM2 ASGR1 C3orf52 CTSA CYB5B CYBC1 FAM3C GABARAPL1 GABARAPL2 IGFBP5 PRAP1 SUMO2 TSPO2 UBIAD1 VAMP3 ZFPL1
Entrez ID		115708	113146
HPRD ID		08810	12261
Ensembl ID		ENSG00000166166	ENSG00000185567
Uniprot IDs		Q96FX7	Q8IVF2
PDB IDs		5CCB 5CCX 5CD1	4CN0
GO Terms Enriched among Interactors		None	Cellular Response To Nitrogen Starvation Endoplasmic Reticulum Phosphatidylethanolamine Binding GABA Receptor Binding Negative Regulation Of Skeletal Muscle Hypertrophy Beta-tubulin Binding Vitamin K Biosynthetic Process Menaquinone Biosynthetic Process Organelle Membrane Positive Regulation Of Triglyceride Transport 5-aminolevulinic Acid Import Across Plasma Membrane 5-aminolevulinic Acid Transmembrane Transporter Activity Autophagosome Maturation Autophagosome Membrane