TCL1A and AKT3

Number of citations of the paper that reports this interaction (PubMedID 11707444)
0

Data Source:
HPRD (in vitro, in vivo)

		TCL1A	AKT3
Description		TCL1 family AKT coactivator A	AKT serine/threonine kinase 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cilium Membrane Ciliary Basal Body
	Molecular Function	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Intracellular Signal Transduction	Positive Regulation Of Endothelial Cell Proliferation Protein Phosphorylation Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of TOR Signaling Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Cell Size Brain Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Artery Morphogenesis Negative Regulation Of Cellular Senescence
Pathways			Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network AKT-mediated inactivation of FOXO1A CD28 dependent PI3K/Akt signaling Co-inhibition by CTLA4 G beta:gamma signalling through PI3Kgamma VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling KEAP1-NFE2L2 pathway SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases
GWAS		Adverse response to aromatase inhibitors ( 20876420) Mosaic loss of chromosome Y ( 27064253) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Plateletcrit ( 32888494) Refractive error ( 32231278)	Adult body size ( 32376654) Adult diffuse glioma (IDH mutation) ( 32386320) Adventurousness ( 30643258) Antisaccade task score ( 31596458) Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diabetic retinopathy ( 21441570) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Educational attainment ( 25201988) ghrelin levels ( 33852427) Height ( 28552196) Menarche (age at onset) ( 23599027) Monocyte count ( 32888494) Non-glioblastoma glioma ( 28346443) Platelet distribution width ( 32888494) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) RR interval (heart rate) ( 20031603) Schizophrenia ( 25056061 23974872 28991256 30285260 29483656) Self-reported risk-taking behaviour ( 30181555) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		37 interacting genes: AKT1 AKT2 AKT3 ATM CADPS CALCOCO2 CARD9 CASP8AP2 CCDC13 CEP55 DDIT4L FLACC1 GOLGA2 H2AC25 INCA1 LNX1 LNX2 LSM3 NFKBIA NFKBID NIF3L1 NTAQ1 PPP1R13B PRTFDC1 REL TAX1BP1 TCF4 TEPSIN TNKS TP53BP2 TRAF1 TRAF2 TRMT61A TTC33 TXLNA TXLNB WDR47	12 interacting genes: CRYAA FBXO7 GSK3B IWS1 NEDD4 NEDD4L PDPK1 PPP2CA PRKCD PRKCZ TCL1A TSC2
Entrez ID		8115	10000
HPRD ID		01744	06441
Ensembl ID		ENSG00000100721	ENSG00000117020
Uniprot IDs		P56279	A0A5F9ZHU3 A0A7P0TB32 A0A7P0TBJ6 Q9Y243
PDB IDs		1JSG	2X18 8ZXW
Enriched GO Terms of Interacting Partners?		Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Apoptotic Signaling Pathway Identical Protein Binding Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Cytoplasm Signaling Adaptor Activity Non-canonical NF-kappaB Signal Transduction Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Toll-like Receptor 4 Signaling Pathway Peptidyl-serine Phosphorylation Negative Regulation Of Fatty Acid Transport Programmed Cell Death Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Cell Death Cell Surface Toll-like Receptor Signaling Pathway Negative Regulation Of Lipid Transport Protein Binding Regulation Of Apoptotic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Syntaxin Binding Regulation Of Programmed Cell Death Thioesterase Binding Cell Surface Pattern Recognition Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Protein Polyubiquitination Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Telomere Capping Myelin Maintenance Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway Mammary Gland Epithelial Cell Differentiation Glycogen Biosynthetic Process Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Glycogen Biosynthetic Process Insulin Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of T-helper 17 Type Immune Response Negative Regulation Of Cell Cycle Response To Muramyl Dipeptide Intracellular Signal Transduction Peptidyl-threonine Phosphorylation Regulation Of Response To Endoplasmic Reticulum Stress Polysaccharide Biosynthetic Process Positive Regulation Of Telomere Maintenance Via Telomerase	Regulation Of Transport Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Catabolic Process Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Protein Kinase Binding Regulation Of Intracellular Transport Protein Modification Process Regulation Of Nucleocytoplasmic Transport Regulation Of Cellular Localization Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Cytoplasm Regulation Of Protein Stability Sodium Channel Inhibitor Activity Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Dendrite Morphogenesis Developmental Process Negative Regulation Of Transport Negative Regulation Of Cation Transmembrane Transport Regulation Of Membrane Potential Regulation Of Neuron Projection Development Potassium Channel Inhibitor Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Nucleus Regulation Of Potassium Ion Export Across Plasma Membrane Cytosol Protein Metabolic Process Insulin Receptor Substrate Binding Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Sodium Ion Transport Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Apoptotic Process Establishment Of Cell Polarity Regulation Of Monoatomic Cation Transmembrane Transport Vascular Endothelial Cell Response To Fluid Shear Stress
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