TRMT61A and ADSS1

		TRMT61A	ADSS1
Description		tRNA methyltransferase 61A	adenylosuccinate synthase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm TRNA (m1A) Methyltransferase Complex	Cytoplasm Cytosol
	Molecular Function	Protein Binding Methyltransferase Activity Transferase Activity MRNA (adenine-N1-)-methyltransferase Activity TRNA (adenine(58)-N1)-methyltransferase Activity	Nucleotide Binding Magnesium Ion Binding GTPase Activity Adenylosuccinate Synthase Activity Protein Binding GTP Binding Ligase Activity Phosphate Ion Binding Identical Protein Binding Metal Ion Binding Actin Filament Binding
	Biological Process	RNA Processing MRNA Processing TRNA Processing TRNA Methylation Methylation	Immune System Process Purine Nucleotide Metabolic Process Purine Nucleotide Biosynthetic Process AMP Biosynthetic Process Aspartate Metabolic Process Glutamine Metabolic Process Response To Muscle Activity Response To Starvation 'de Novo' AMP Biosynthetic Process AMP Salvage IMP Metabolic Process Cellular Response To Electrical Stimulus Cellular Response To Xenobiotic Stimulus
Pathways		tRNA modification in the nucleus and cytosol	Purine ribonucleoside monophosphate biosynthesis
Drugs			Aspartic acid Hadacidin 6-O-Phosphoryl Inosine Monophosphate Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate Adenylosuccinic acid Inosinic Acid Alanosine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Branched-chain amino acid levels (Isoleucine) ( 27898682) Extremely high intelligence ( 29520040) Hemoglobin levels ( 32327693) Intelligence (MTAG) ( 29326435) Mean corpuscular volume ( 27863252 32888494) Red blood cell count ( 32888494) Schizophrenia ( 25056061)
Interacting Genes		2 interacting genes: TCL1A TRMT6	2 interacting genes: AZIN1 LYAR
Entrez ID		115708	122622
HPRD ID		08810	12433
Ensembl ID		ENSG00000166166	ENSG00000185100
Uniprot IDs		Q96FX7	B3KTV4 Q8N142
PDB IDs		5CCB 5CCX 5CD1
Enriched GO Terms of Interacting Partners?			Ornithine Decarboxylase Activity Ornithine Decarboxylase Activator Activity Positive Regulation Of Polyamine Transmembrane Transport Putrescine Biosynthetic Process From Arginine, Via Ornithine MRNA (adenine-N1-)-methyltransferase Activity TRNA (m1A) Methyltransferase Complex TRNA (adenine(58)-N1)-methyltransferase Activity Putrescine Biosynthetic Process Putrescine Metabolic Process Polyamine Biosynthetic Process Arginine Metabolic Process Polyamine Metabolic Process
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