TRMT61A and TRMT6

Number of citations: 41 (PubMedID 16043508)
Data Source: HPRD (in vivo)

		TRMT61A	TRMT6
Name		tRNA methyltransferase 61A	tRNA methyltransferase 6 non-catalytic subunit
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm TRNA (m1A) Methyltransferase Complex	Nucleus Nucleoplasm TRNA (m1A) Methyltransferase Complex
	Molecular Function	Protein Binding Methyltransferase Activity Transferase Activity MRNA (adenine-N1-)-methyltransferase Activity TRNA (adenine(58)-N1)-methyltransferase Activity	RNA Binding Protein Binding
	Biological Process	RNA Processing MRNA Processing TRNA Processing TRNA Methylation Methylation	MRNA Processing TRNA Processing TRNA Methylation
Pathways		tRNA modification in the nucleus and cytosol	tRNA modification in the nucleus and cytosol
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Body mass index ( 26426971 ) Brain morphology (MOSTest) ( 32665545 ) Branched-chain amino acid levels (Isoleucine) ( 27898682 ) Extremely high intelligence ( 29520040 ) Hemoglobin levels ( 32327693 ) Intelligence (MTAG) ( 29326435 ) Mean corpuscular volume ( 27863252 32888494 ) Red blood cell count ( 32888494 ) Schizophrenia ( 25056061 )	ghrelin levels ( 33852427 ) Menarche and menopause (age at onset) ( 19448621 ) Uterine fibroids ( 31649266 )
Interacting Genes		2 interacting genes: TCL1A TRMT6	4 interacting genes: FOXJ1 HHEX OGT TRMT61A
Entrez ID		115708	51605
HPRD ID		08810	13027
Ensembl ID		ENSG00000166166	ENSG00000089195
Uniprot IDs		Q96FX7	Q9UJA5
PDB IDs		5CCB 5CCX 5CD1	5CCB 5CCX 5CD1
GO Terms Enriched among Interactors		None	Glomerular Parietal Epithelial Cell Development Positive Regulation Of Central B Cell Tolerance Induction Regulation Of Translational Initiation Negative Regulation Of Translational Initiation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Central Tolerance Induction Positive Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of B Cell Tolerance Induction Negative Regulation Of Germinal Center Formation Negative Regulation Of Cytoplasmic Translational Initiation MRNA (adenine-N1-)-methyltransferase Activity TRNA (adenine(58)-N1)-methyltransferase Activity Negative Regulation Of Developmental Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Translation Protein O-acetylglucosaminyltransferase Activity TRNA (m1A) Methyltransferase Complex Metanephric Part Of Ureteric Bud Development Transcription Cis-regulatory Region Binding Negative Regulation Of DNA-templated Transcription Ciliary Basal Body Organization Regulation Of Leukocyte Proliferation Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Regionalization Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Germinal Center Formation Eukaryotic Initiation Factor 4E Binding Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By Glucose Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of MRNA Export From Nucleus Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Tolerance Induction Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway NSL Complex Left/right Pattern Formation Negative Regulation Of Transcription By Competitive Promoter Binding