TRMT61A and PLD4

Data Source: HiPPIP (Novel)

		TRMT61A	PLD4
Name		tRNA methyltransferase 61A	phospholipase D family member 4
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm TRNA (m1A) Methyltransferase Complex	Nucleus Lysosome Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Endomembrane System Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Phagocytic Vesicle
	Molecular Function	Protein Binding Methyltransferase Activity Transferase Activity MRNA (adenine-N1-)-methyltransferase Activity TRNA (adenine(58)-N1)-methyltransferase Activity	Catalytic Activity Nuclease Activity Exonuclease Activity Phospholipase D Activity Hydrolase Activity Single-stranded DNA 5'-3' DNA Exonuclease Activity
	Biological Process	RNA Processing MRNA Processing TRNA Processing TRNA Methylation Methylation	Hematopoietic Progenitor Cell Differentiation Immune System Process DNA Metabolic Process Lipid Metabolic Process Phagocytosis Inflammatory Response Innate Immune Response Establishment Of Localization In Cell Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways		tRNA modification in the nucleus and cytosol	Synthesis of PG Synthesis of IP3 and IP4 in the cytosol Role of phospholipids in phagocytosis
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Body mass index ( 26426971 ) Brain morphology (MOSTest) ( 32665545 ) Branched-chain amino acid levels (Isoleucine) ( 27898682 ) Extremely high intelligence ( 29520040 ) Hemoglobin levels ( 32327693 ) Intelligence (MTAG) ( 29326435 ) Mean corpuscular volume ( 27863252 32888494 ) Red blood cell count ( 32888494 ) Schizophrenia ( 25056061 )	Cerebrospinal fluid t-tau levels ( 29274321 ) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321 ) Rheumatoid arthritis ( 22446963 24390342 30423114 32723749 )
Novel Interactors		8 novel interactors: ADSS1 AHNAK2 CLBA1 COA8 IGHV5-78 PLD4 TDRD9 TMEM121	1 novel interactors: TRMT61A
Interacting Genes		2 interacting genes: TCL1A TRMT6	None recorded
Entrez ID		115708	122618
HPRD ID		08810	11230
Ensembl ID		ENSG00000166166	ENSG00000166428
Uniprot IDs		Q96FX7	B4DI07 B4DJQ6 F5H2B5 Q96BZ4
PDB IDs		5CCB 5CCX 5CD1	8V08
GO Terms Enriched among Interactors		None	MRNA (adenine-N1-)-methyltransferase Activity TRNA (m1A) Methyltransferase Complex TRNA (adenine(58)-N1)-methyltransferase Activity TRNA Methylation TRNA Modification RNA Methylation Macromolecule Methylation TRNA Processing RNA Modification TRNA Metabolic Process Methyltransferase Activity Methylation