TRMT61A and COA8

Data Source: HiPPIP (Novel)

		TRMT61A	COA8
Name		tRNA methyltransferase 61A	cytochrome c oxidase assembly factor 8
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm TRNA (m1A) Methyltransferase Complex	Mitochondrion Mitochondrial Inner Membrane Membrane Matrix Side Of Mitochondrial Inner Membrane
	Molecular Function	Protein Binding Methyltransferase Activity Transferase Activity MRNA (adenine-N1-)-methyltransferase Activity TRNA (adenine(58)-N1)-methyltransferase Activity	Protein Binding
	Biological Process	RNA Processing MRNA Processing TRNA Processing TRNA Methylation Methylation	Response To Reactive Oxygen Species Apoptotic Process Mitochondrial Cytochrome C Oxidase Assembly Protein Stabilization Intrinsic Apoptotic Signaling Pathway
Pathways		tRNA modification in the nucleus and cytosol	None
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Body mass index ( 26426971 ) Brain morphology (MOSTest) ( 32665545 ) Branched-chain amino acid levels (Isoleucine) ( 27898682 ) Extremely high intelligence ( 29520040 ) Hemoglobin levels ( 32327693 ) Intelligence (MTAG) ( 29326435 ) Mean corpuscular volume ( 27863252 32888494 ) Red blood cell count ( 32888494 ) Schizophrenia ( 25056061 )	Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 )
Novel Interactors		8 novel interactors: ADSS1 AHNAK2 CLBA1 COA8 IGHV5-78 PLD4 TDRD9 TMEM121	5 novel interactors: AHNAK2 IGHV5-78 INF2 TDRD9 TRMT61A
Interacting Genes		2 interacting genes: TCL1A TRMT6	None recorded
Entrez ID		115708	84334
HPRD ID		08810	12637
Ensembl ID		ENSG00000166166	ENSG00000256053
Uniprot IDs		Q96FX7	A0A6Q8JUI0 G3V4L6 Q96IL0
PDB IDs		5CCB 5CCX 5CD1	Not available
GO Terms Enriched among Interactors		None	MRNA (adenine-N1-)-methyltransferase Activity TRNA (m1A) Methyltransferase Complex TRNA (adenine(58)-N1)-methyltransferase Activity Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation PiP-body