ADSS1 and TRMT61A

		ADSS1	TRMT61A
Description		adenylosuccinate synthase 1	tRNA methyltransferase 61A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm TRNA (m1A) Methyltransferase Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding GTPase Activity Adenylosuccinate Synthase Activity Protein Binding GTP Binding Ligase Activity Phosphate Ion Binding Identical Protein Binding Metal Ion Binding Actin Filament Binding	Protein Binding Methyltransferase Activity Transferase Activity MRNA (adenine-N1-)-methyltransferase Activity TRNA (adenine(58)-N1)-methyltransferase Activity
	Biological Process	Immune System Process Purine Nucleotide Metabolic Process Purine Nucleotide Biosynthetic Process AMP Biosynthetic Process Aspartate Metabolic Process Glutamine Metabolic Process Response To Muscle Activity Response To Starvation 'de Novo' AMP Biosynthetic Process AMP Salvage IMP Metabolic Process Cellular Response To Electrical Stimulus Cellular Response To Xenobiotic Stimulus	RNA Processing MRNA Processing TRNA Processing TRNA Methylation Methylation
Pathways		Purine ribonucleoside monophosphate biosynthesis	tRNA modification in the nucleus and cytosol
Drugs		Aspartic acid Hadacidin 6-O-Phosphoryl Inosine Monophosphate Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate Adenylosuccinic acid Inosinic Acid Alanosine
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Branched-chain amino acid levels (Isoleucine) ( 27898682) Extremely high intelligence ( 29520040) Hemoglobin levels ( 32327693) Intelligence (MTAG) ( 29326435) Mean corpuscular volume ( 27863252 32888494) Red blood cell count ( 32888494) Schizophrenia ( 25056061)
Interacting Genes		2 interacting genes: AZIN1 LYAR	2 interacting genes: TCL1A TRMT6
Entrez ID		122622	115708
HPRD ID		12433	08810
Ensembl ID		ENSG00000185100	ENSG00000166166
Uniprot IDs		B3KTV4 Q8N142	Q96FX7
PDB IDs			5CCB 5CCX 5CD1
Enriched GO Terms of Interacting Partners?		Ornithine Decarboxylase Activity Ornithine Decarboxylase Activator Activity Positive Regulation Of Polyamine Transmembrane Transport Putrescine Biosynthetic Process From Arginine, Via Ornithine MRNA (adenine-N1-)-methyltransferase Activity TRNA (m1A) Methyltransferase Complex TRNA (adenine(58)-N1)-methyltransferase Activity Putrescine Biosynthetic Process Putrescine Metabolic Process Polyamine Biosynthetic Process Arginine Metabolic Process Polyamine Metabolic Process
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