ADRB1 and MAGI2

Number of citations of the paper that reports this interaction (PubMedID 11526121)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		ADRB1	MAGI2
Description		adrenoceptor beta 1	membrane associated guanylate kinase, WW and PDZ domain containing 2
Image
GO Annotations	Cellular Component	Endosome Early Endosome Plasma Membrane Membrane Schaffer Collateral - CA1 Synapse Neuronal Dense Core Vesicle	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Cytoplasm Endosome Late Endosome Centrosome Centriole Cytoskeleton Plasma Membrane Cell-cell Junction Bicellular Tight Junction Cilium Postsynaptic Density Membrane Dendrite Protein-containing Complex Slit Diaphragm Cell Projection Neuron Projection Synapse Perinuclear Region Of Cytoplasm Ciliary Base
	Molecular Function	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Beta-adrenergic Receptor Activity Beta1-adrenergic Receptor Activity Protein Binding PDZ Domain Binding Alpha-2A Adrenergic Receptor Binding Protein Heterodimerization Activity G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Binding Phosphatase Binding Signaling Receptor Complex Adaptor Activity Beta-1 Adrenergic Receptor Binding SMAD Binding Type II Activin Receptor Binding
	Biological Process	Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Diet Induced Thermogenesis Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Cold Heat Generation Negative Regulation Of Multicellular Organism Growth Fear Response Positive Regulation Of MAPK Cascade Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Heart Contraction Brown Fat Cell Differentiation Regulation Of Postsynaptic Membrane Potential Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis	Positive Regulation Of Receptor Internalization Endocytosis Signal Transduction Nervous System Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Negative Regulation Of Activin Receptor Signaling Pathway Nerve Growth Factor Signaling Pathway Receptor Clustering Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway SMAD Protein Signal Transduction Podocyte Development Clathrin-dependent Endocytosis Cellular Response To Nerve Growth Factor Stimulus
Pathways		Adrenoceptors G alpha (s) signalling events	Nephrin family interactions
Drugs		Spermine Amphetamine Esmolol Betaxolol Bethanidine Isoetharine Ranolazine Cabergoline Metoprolol Metoprolol Olanzapine Atenolol Norepinephrine Timolol Phenylpropanolamine Loxapine Sotalol Carteolol Nortriptyline Lamotrigine Propranolol Labetalol Bisoprolol Epinephrine Paroxetine Trimipramine Cryptenamine Dobutamine Pseudoephedrine Alprenolol Ritodrine Terbutaline Salmeterol Pindolol Formoterol Salbutamol Ergoloid mesylate Isoprenaline Arbutamine Amiodarone Carvedilol Desipramine Propafenone Acebutolol Nadolol Levobunolol Metipranolol Aripiprazole Fenoterol Pirbuterol Bevantolol Practolol Penbutolol Ephedra sinica root Ephedrine Mephentermine Clenbuterol Oxprenolol Putrescine Spermidine Celiprolol Dronedarone Nebivolol Asenapine Droxidopa Bufuralol 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL Bopindolol Bupranolol Mirabegron Befunolol Vortioxetine Arotinolol Levobetaxolol Racepinephrine Dihydroergocornine DL-Methylephedrine DL-Methylephedrine Dihydroergocristine Xamoterol
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Birth weight ( 23202124 31043758 27680694) Blood pressure ( 21909110) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Gaucher disease severity ( 22388998) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 29083408) LDL cholesterol levels ( 32203549) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Platelet distribution width ( 32888494) PR interval ( 32439900) Systolic blood pressure ( 27618447 30578418 27618452 27841878 28739976) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 32203549)	Acute lymphoblastic leukemia (childhood) ( 23007406) Adult body size ( 32376654) Adverse response to drug ( 30420678) Airway wall thickness ( 25517131) Bitter beverage consumption ( 31046077) Body mass index ( 25673413 28892062) Body size at age 10 ( 32376654) Bronchopulmonary dysplasia ( 23897914) Chronotype ( 30696823) Computer vision syndrome ( 33941792) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) General risk tolerance (MTAG) ( 30643258) Hippocampal atrophy ( 19668339) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol levels x short total sleep time interaction (1df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lead levels in blood ( 25820613) Low density lipoprotein cholesterol levels ( 33339817) Mammographic density (dense area) ( 25342443) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Metabolite levels ( 23823483) Nicotine dependence ( 33144568) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) Response to anti-depressant treatment in major depressive disorder ( 22041458) Response to lamotrigine and valproic acid in genetic generalized epilepsy ( 32308125) Schizophrenia ( 30285260 28991256) Serum folate levels ( 29953918) Total cholesterol levels ( 33339817) Visceral fat ( 30942860)
Interacting Genes		17 interacting genes: ADRA2A ADRB2 ARRB1 DLG1 DLG4 DLGAP2 GIPC1 GOPC GPRASP1 GPRASP2 GRB2 MAGI2 MAGI3 NOS1 SH3GL2 SH3GL3 SNTA1	30 interacting genes: ACVR2A ADGRB1 ADRB1 ARRDC3 ATN1 CRHR1 CTNNB1 CTNND2 DLGAP1 DLGAP2 DLGAP3 DLL1 DSCAM DSCAML1 DYRK3 GRID2 LCOR MORN4 PDZD11 PLEKHF2 PLXNB3 PRRG4 PTEN RAPGEF2 RIPK4 RPS6KA1 SMAD3 SNRPB TGFA VANGL2
Entrez ID		153	9863
HPRD ID		00181	16212
Ensembl ID		ENSG00000043591	ENSG00000187391
Uniprot IDs		P08588	B7Z4H4 Q86UL8
PDB IDs		2LSQ 7BTS 7BU6 7BU7 7BVQ	1UEP 1UEQ 1UEW 1UJV 1WFV
Enriched GO Terms of Interacting Partners?		Regulation Of Transport Regulation Of Receptor-mediated Endocytosis Postsynaptic Density Glutamatergic Synapse Regulation Of System Process Regulation Of Sodium Ion Transport Regulation Of Receptor Internalization Regulation Of Monoatomic Ion Transport Endocytosis Beta-1 Adrenergic Receptor Binding Regulation Of Muscle System Process Norepinephrine Binding Vesicle-mediated Transport Regulation Of Sodium Ion Transmembrane Transport Regulation Of Cell Communication Regulation Of Signaling Regulation Of Vesicle-mediated Transport Regulation Of Endocytosis Transmembrane Transporter Binding Regulation Of Metal Ion Transport Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor Clustering Synaptic Signaling Synapse Regulation Of Muscle Contraction Vasodilation Regulation Of Signal Transduction Actin Cytoskeleton Organization Plasma Membrane Import Into Cell Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor-mediated Endocytosis Regulation Of MAPK Cascade Adrenergic Receptor Activity System Process GMP Kinase Activity Actin Filament-based Process Muscle Contraction Cell-cell Junction Negative Regulation Of Transport Regulation Of Membrane Potential GDP Metabolic Process Membrane Negative Regulation Of Smooth Muscle Contraction Neuromuscular Junction Cytoplasm Regulation Of Potassium Ion Transport Regulation Of Blood Circulation Signal Transduction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway	PDZ Domain Binding Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Junction Assembly Synapse Synapse Organization Regulation Of Nervous System Development Chemical Synaptic Transmission Cell Junction Organization Signaling Postsynaptic Specialization Trans-synaptic Signaling Synaptic Signaling Postsynaptic Density Anchoring Junction System Development Regionalization Cell-cell Signaling Cell Surface Receptor Signaling Pathway Cell Communication Anatomical Structure Morphogenesis Regulation Of Developmental Process Modulation Of Chemical Synaptic Transmission Cell-cell Junction Synapse Assembly Developmental Process Cell-cell Adhesion Mediator Activity Regulation Of Neurogenesis Glutamatergic Synapse Epithelial Tube Morphogenesis Nervous System Development Regulation Of Striated Muscle Tissue Development Cell Fate Determination Positive Regulation Of Developmental Process Pattern Specification Process Heat Generation Hepatocyte Proliferation Regulation Of Growth Regulation Of Muscle Organ Development Osteoblast Differentiation Gastrulation Embryonic Morphogenesis Animal Organ Development Positive Regulation Of Cellular Component Organization Regulation Of Anatomical Structure Morphogenesis Neuron Projection Morphogenesis Cell Junction Assembly Transcription Corepressor Binding Regulation Of Multicellular Organismal Development
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