ADRB1 and MAGI3

Number of citations of the paper that reports this interaction (PubMedID 16316992)
0

Data Source:
HPRD (in vitro, in vivo)

		ADRB1	MAGI3
Description		adrenoceptor beta 1	membrane associated guanylate kinase, WW and PDZ domain containing 3
Image
GO Annotations	Cellular Component	Endosome Early Endosome Plasma Membrane Membrane Schaffer Collateral - CA1 Synapse Neuronal Dense Core Vesicle	Nucleus Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Anchoring Junction
	Molecular Function	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Beta-adrenergic Receptor Activity Beta1-adrenergic Receptor Activity Protein Binding PDZ Domain Binding Alpha-2A Adrenergic Receptor Binding Protein Heterodimerization Activity G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential	Nucleotide Binding GMP Kinase Activity Frizzled Binding Protein Binding ATP Binding
	Biological Process	Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Diet Induced Thermogenesis Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Cold Heat Generation Negative Regulation Of Multicellular Organism Growth Fear Response Positive Regulation Of MAPK Cascade Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Heart Contraction Brown Fat Cell Differentiation Regulation Of Postsynaptic Membrane Potential Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis	Apoptotic Process Signal Transduction Intracellular Signal Transduction GMP Metabolic Process GDP Metabolic Process
Pathways		Adrenoceptors G alpha (s) signalling events
Drugs		Spermine Amphetamine Esmolol Betaxolol Bethanidine Isoetharine Ranolazine Cabergoline Metoprolol Metoprolol Olanzapine Atenolol Norepinephrine Timolol Phenylpropanolamine Loxapine Sotalol Carteolol Nortriptyline Lamotrigine Propranolol Labetalol Bisoprolol Epinephrine Paroxetine Trimipramine Cryptenamine Dobutamine Pseudoephedrine Alprenolol Ritodrine Terbutaline Salmeterol Pindolol Formoterol Salbutamol Ergoloid mesylate Isoprenaline Arbutamine Amiodarone Carvedilol Desipramine Propafenone Acebutolol Nadolol Levobunolol Metipranolol Aripiprazole Fenoterol Pirbuterol Bevantolol Practolol Penbutolol Ephedra sinica root Ephedrine Mephentermine Clenbuterol Oxprenolol Putrescine Spermidine Celiprolol Dronedarone Nebivolol Asenapine Droxidopa Bufuralol 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL Bopindolol Bupranolol Mirabegron Befunolol Vortioxetine Arotinolol Levobetaxolol Racepinephrine Dihydroergocornine DL-Methylephedrine DL-Methylephedrine Dihydroergocristine Xamoterol
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Birth weight ( 23202124 31043758 27680694) Blood pressure ( 21909110) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Gaucher disease severity ( 22388998) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 29083408) LDL cholesterol levels ( 32203549) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Platelet distribution width ( 32888494) PR interval ( 32439900) Systolic blood pressure ( 27618447 30578418 27618452 27841878 28739976) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 32203549)	Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alopecia areata ( 25608926) Autoimmune thyroid disease ( 32581359) Bacteremia ( 27236921) Bulimia nervosa ( 23568457) Cerebrospinal fluid clusterin levels ( 26545630) Cognitive decline rate in late mild cognitive impairment ( 26252872) Crohn's disease ( 28067908) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa) ( 27694959) Leukocyte telomere length ( 32109421) Lung cancer ( 31577861) Myocardial infarction ( 33532862) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Obesity-related traits ( 23251661) Parental lifespan ( 30642433) Type 1 diabetes and autoimmune thyroid diseases ( 25936594)
Interacting Genes		17 interacting genes: ADRA2A ADRB2 ARRB1 DLG1 DLG4 DLGAP2 GIPC1 GOPC GPRASP1 GPRASP2 GRB2 MAGI2 MAGI3 NOS1 SH3GL2 SH3GL3 SNTA1	24 interacting genes: ADGRB1 ADRB1 BRSK2 CDK16 CRHR1 DSCAM DSCAML1 ERBB4 FMR1 FZD4 FZD7 GRIN2B LATS1 MECOM NRCAM PLXNB3 PRRG4 PTEN PTPRB RPS6KA1 RUNX1 TGFA TNK2 VANGL2
Entrez ID		153	260425
HPRD ID		00181	11290
Ensembl ID		ENSG00000043591	ENSG00000081026
Uniprot IDs		P08588	Q5TCQ9
PDB IDs		2LSQ 7BTS 7BU6 7BU7 7BVQ	3SOE
Enriched GO Terms of Interacting Partners?		Regulation Of Transport Regulation Of Receptor-mediated Endocytosis Postsynaptic Density Glutamatergic Synapse Regulation Of System Process Regulation Of Sodium Ion Transport Regulation Of Receptor Internalization Regulation Of Monoatomic Ion Transport Endocytosis Beta-1 Adrenergic Receptor Binding Regulation Of Muscle System Process Norepinephrine Binding Vesicle-mediated Transport Regulation Of Sodium Ion Transmembrane Transport Regulation Of Cell Communication Regulation Of Signaling Regulation Of Vesicle-mediated Transport Regulation Of Endocytosis Transmembrane Transporter Binding Regulation Of Metal Ion Transport Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor Clustering Synaptic Signaling Synapse Regulation Of Muscle Contraction Vasodilation Regulation Of Signal Transduction Actin Cytoskeleton Organization Plasma Membrane Import Into Cell Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor-mediated Endocytosis Regulation Of MAPK Cascade Adrenergic Receptor Activity System Process GMP Kinase Activity Actin Filament-based Process Muscle Contraction Cell-cell Junction Negative Regulation Of Transport Regulation Of Membrane Potential GDP Metabolic Process Membrane Negative Regulation Of Smooth Muscle Contraction Neuromuscular Junction Cytoplasm Regulation Of Potassium Ion Transport Regulation Of Blood Circulation Signal Transduction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway	Developmental Process Regulation Of Developmental Process Plasma Membrane PDZ Domain Binding Regulation Of Cellular Component Organization Regulation Of Developmental Growth Synapse Cell-cell Adhesion Mediator Activity Synapse Assembly Postsynaptic Density Membrane System Development Nervous System Development Regulation Of Cell Communication Regulation Of Growth Regulation Of Signaling Regulation Of Biological Quality Neuron Projection Morphogenesis Cell Projection Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Axonogenesis Regulation Of Cell Projection Organization Signal Transduction Negative Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Cellular Developmental Process Neuron Projection Regulation Of Multicellular Organismal Process Neuron Differentiation Regulation Of Organ Growth Cardiac Muscle Tissue Regeneration Phosphorylation Anatomical Structure Morphogenesis Regulation Of Anatomical Structure Morphogenesis Epidermal Growth Factor Receptor Binding Regulation Of Phosphorylation Regulation Of Cell Differentiation Cell Differentiation Cell Recognition Regulation Of Nervous System Development Regulation Of Neuron Projection Development Synapse Organization Cell Junction Assembly Regulation Of Synaptic Vesicle Clustering Positive Regulation Of Nervous System Development Neuron Recognition Hepatocyte Proliferation Neuron Projection Development Positive Regulation Of Developmental Process Regulation Of Axonogenesis Non-canonical Wnt Signaling Pathway
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