ADRB1 and NOS1

Number of citations of the paper that reports this interaction (PubMedID 12184796)
15

Data Source:
HPRD (in vivo)

		ADRB1	NOS1
Description		adrenoceptor beta 1	nitric oxide synthase 1
Image
GO Annotations	Cellular Component	Endosome Early Endosome Plasma Membrane Membrane Schaffer Collateral - CA1 Synapse Neuronal Dense Core Vesicle	Photoreceptor Inner Segment Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Caveola Endomembrane System Postsynaptic Density Membrane Sarcoplasmic Reticulum Z Disc T-tubule Protein-containing Complex Sarcoplasmic Reticulum Membrane Sarcolemma Cell Projection Dendritic Spine Calyx Of Held Membrane Raft Synapse Perinuclear Region Of Cytoplasm Cell Periphery
	Molecular Function	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Beta-adrenergic Receptor Activity Beta1-adrenergic Receptor Activity Protein Binding PDZ Domain Binding Alpha-2A Adrenergic Receptor Binding Protein Heterodimerization Activity G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential	Nitric-oxide Synthase Activity Calcium Channel Regulator Activity Protein Binding Calmodulin Binding FMN Binding Oxidoreductase Activity Sodium Channel Regulator Activity Heme Binding Tetrahydrobiopterin Binding Arginine Binding Peptidyl-cysteine S-nitrosylase Activity Transmembrane Transporter Binding Cadmium Ion Binding Metal Ion Binding Calcium-dependent Protein Binding Flavin Adenine Dinucleotide Binding NADP Binding Scaffold Protein Binding
	Biological Process	Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Diet Induced Thermogenesis Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Cold Heat Generation Negative Regulation Of Multicellular Organism Growth Fear Response Positive Regulation Of MAPK Cascade Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Heart Contraction Brown Fat Cell Differentiation Regulation Of Postsynaptic Membrane Potential Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis	Response To Hypoxia Regulation Of Sodium Ion Transport L-arginine Catabolic Process Nitric Oxide Biosynthetic Process Potassium Ion Transport Calcium Ion Transport Striated Muscle Contraction Cell Communication Nitric Oxide Mediated Signal Transduction Myoblast Fusion Blood Circulation Response To Heat Response To Hormone Negative Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Metal Ion Transport Signaling Response To Lipopolysaccharide Multicellular Organismal Response To Stress Xenobiotic Catabolic Process Vasodilation Negative Regulation Of Potassium Ion Transport Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Neuron Apoptotic Process Cell Redox Homeostasis Negative Regulation Of Blood Pressure Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Negative Regulation Of Serotonin Uptake Establishment Of Localization In Cell Negative Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Postsynaptic Membrane Potential Regulation Of Biological Quality Cellular Response To Growth Factor Stimulus Positive Regulation Of The Force Of Heart Contraction Synaptic Signaling By Nitric Oxide Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Sodium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Blood Circulation Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential
Pathways		Adrenoceptors G alpha (s) signalling events	ROS and RNS production in phagocytes Nitric oxide stimulates guanylate cyclase Ion homeostasis
Drugs		Spermine Amphetamine Esmolol Betaxolol Bethanidine Isoetharine Ranolazine Cabergoline Metoprolol Metoprolol Olanzapine Atenolol Norepinephrine Timolol Phenylpropanolamine Loxapine Sotalol Carteolol Nortriptyline Lamotrigine Propranolol Labetalol Bisoprolol Epinephrine Paroxetine Trimipramine Cryptenamine Dobutamine Pseudoephedrine Alprenolol Ritodrine Terbutaline Salmeterol Pindolol Formoterol Salbutamol Ergoloid mesylate Isoprenaline Arbutamine Amiodarone Carvedilol Desipramine Propafenone Acebutolol Nadolol Levobunolol Metipranolol Aripiprazole Fenoterol Pirbuterol Bevantolol Practolol Penbutolol Ephedra sinica root Ephedrine Mephentermine Clenbuterol Oxprenolol Putrescine Spermidine Celiprolol Dronedarone Nebivolol Asenapine Droxidopa Bufuralol 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL Bopindolol Bupranolol Mirabegron Befunolol Vortioxetine Arotinolol Levobetaxolol Racepinephrine Dihydroergocornine DL-Methylephedrine DL-Methylephedrine Dihydroergocristine Xamoterol	Citrulline Donepezil Ketamine L-N(omega)-Nitroarginine-2,4-L-diaminobutyric amide Formic acid 3-Bromo-7-Nitroindazole N-{(4S)-4-Amino-5-[(2-aminoethyl)amino]pentyl}-N'-nitroguanidine N-[3-(aminomethyl)benzyl]acetamidine L-N(omega)-nitroarginine-(4R)-amino-L-proline amide 1-hydroxy-2-isopropylguanidine 7-Nitroindazole N-omega-propyl-L-arginine 2-butyl-1-hydroxyguanidine S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine Flavin adenine dinucleotide Flavin mononucleotide N-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide Nicotinamide adenine dinucleotide phosphate S-Ethyl-N-Phenyl-Isothiourea [(1S)-4-(1-Aminobutylideneamino)-1-carboxybutyl]azanium 5-N-Allyl-arginine Nitroarginine NXN-188 N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine Methylene blue
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Birth weight ( 23202124 31043758 27680694) Blood pressure ( 21909110) Diastolic blood pressure ( 27618452 27841878 28135244 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Gaucher disease severity ( 22388998) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 29083408) LDL cholesterol levels ( 32203549) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Platelet distribution width ( 32888494) PR interval ( 32439900) Systolic blood pressure ( 27618447 30578418 27618452 27841878 28739976) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 32203549)	Anxiety ( 33859377) Baseline cortisol levels in response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Colorectal cancer ( 26151821) Colorectal cancer or advanced adenoma ( 30510241) Depression ( 33859377) Disability (impaired activities of daily living) ( 31707593) General factor of neuroticism ( 30867560) Neuroticism ( 29255261) Schizophrenia ( 28991256 30285260)
Interacting Genes		17 interacting genes: ADRA2A ADRB2 ARRB1 DLG1 DLG4 DLGAP2 GIPC1 GOPC GPRASP1 GPRASP2 GRB2 MAGI2 MAGI3 NOS1 SH3GL2 SH3GL3 SNTA1	33 interacting genes: ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ARG1 ATP2B4 BDKRB2 CAMK1 CAMK2A CAMK4 CAV3 CTBP1 DLG2 DLG4 DLGAP2 DYNLL1 HMOX1 HSP90AA1 NOS1AP NOSIP PFKM PRKACA PRKCA PRKD1 PTPN6 PTPRN RASD1 SNTA1 STUB1 SYN1 VAC14 ZDHHC23
Entrez ID		153	4842
HPRD ID		00181	01226
Ensembl ID		ENSG00000043591	ENSG00000089250
Uniprot IDs		P08588	A0PJJ7 B3VK56 B4DG68 P29475
PDB IDs		2LSQ 7BTS 7BU6 7BU7 7BVQ	4D1N 4UCH 4UH5 4UH6 4V3U 5ADF 5ADG 5ADI 5FVU 5FVV 5FVW 5FVX 5UO1 5UO2 5UO3 5UO4 5UO5 5UO6 5UO7 5VUV 5VUW 5VUX 5VUY 5VUZ 5VV0 5VV1 5VV2 5VV3 5VV4 5VV5 6AUY 6AUZ 6AV0 6AV1 6AV2 6AV3 6AV4 6AV5 6CIC 6CID 6NG1 6NG2 6NG4 6NG5 6NG6 6NG7 6NG8 6NGA 6NGB 6NGC 6NGD 6NGE 6NGF 6NGH 6NGI 6NHB 6NHC 6PNA 6PNB 6PNC 6PND 6PNE 6PNF 6PNG 6PNH 6PO5 6PO7 6PO8 6PO9 6POA 6POB 6POC 6POT 7TS1 7TS2 7TS3 7TS4 7TS5 7TS6 7TS7 7TS8 7UAM 7US7 7US8 8BI8 8BI9 8FGF 8FGG 8FGH 8FGI 8FGJ 8FGK 8FGL 8FGM 8UFP 8UFQ
Enriched GO Terms of Interacting Partners?		Regulation Of Transport Regulation Of Receptor-mediated Endocytosis Postsynaptic Density Glutamatergic Synapse Regulation Of System Process Regulation Of Sodium Ion Transport Regulation Of Receptor Internalization Regulation Of Monoatomic Ion Transport Endocytosis Beta-1 Adrenergic Receptor Binding Regulation Of Muscle System Process Norepinephrine Binding Vesicle-mediated Transport Regulation Of Sodium Ion Transmembrane Transport Regulation Of Cell Communication Regulation Of Signaling Regulation Of Vesicle-mediated Transport Regulation Of Endocytosis Transmembrane Transporter Binding Regulation Of Metal Ion Transport Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor Clustering Synaptic Signaling Synapse Regulation Of Muscle Contraction Vasodilation Regulation Of Signal Transduction Actin Cytoskeleton Organization Plasma Membrane Import Into Cell Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor-mediated Endocytosis Regulation Of MAPK Cascade Adrenergic Receptor Activity System Process GMP Kinase Activity Actin Filament-based Process Muscle Contraction Cell-cell Junction Negative Regulation Of Transport Regulation Of Membrane Potential GDP Metabolic Process Membrane Negative Regulation Of Smooth Muscle Contraction Neuromuscular Junction Cytoplasm Regulation Of Potassium Ion Transport Regulation Of Blood Circulation Signal Transduction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway	Regulation Of System Process Regulation Of Blood Circulation Adrenergic Receptor Activity Regulation Of Muscle System Process Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Biological Quality Regulation Of Transport Regulation Of Heart Contraction Adrenergic Receptor Signaling Pathway Regulation Of Muscle Contraction System Process Nitric-oxide Synthase Binding Alpha1-adrenergic Receptor Activity Regulation Of Tube Size Blood Vessel Diameter Maintenance Regulation Of Metal Ion Transport Muscle System Process Vascular Process In Circulatory System Regulation Of Striated Muscle Contraction Phosphorylation Regulation Of Heart Rate Regulation Of Multicellular Organismal Process Neuron-glial Cell Signaling Regulation Of Monoatomic Ion Transport Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Circulatory System Process Regulation Of Vasoconstriction Regulation Of Nitric Oxide Metabolic Process G Protein-coupled Receptor Signaling Pathway Regulation Of Cardiac Muscle Hypertrophy Caveola Protein Phosphorylation Nitric-oxide Synthase Regulator Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Temperature Stimulus Neuromuscular Junction Positive Regulation Of Protein Transport Regulation Of Cardiac Muscle Contraction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Monoatomic Cation Transmembrane Transport Response To Cold Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Protein Localization Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Peptide Hormone Secretion Muscle Contraction Positive Regulation Of Cell Communication Positive Regulation Of Signaling
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