PARK7 and SUMO1

Number of citations of the paper that reports this interaction (PubMedID 15983381)
36

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, in vivo)

		PARK7	SUMO1
Description		Parkinsonism associated deglycase	small ubiquitin like modifier 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Endoplasmic Reticulum Cytosol Plasma Membrane Adherens Junction Synaptic Vesicle Membrane PML Body Axon Neuron Projection Cell Body Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome	XY Body Nucleus Nuclear Pore Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Nuclear Body PML Body Nuclear Speck Nuclear Membrane Nuclear Stress Granule Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Core Promoter Sequence-specific DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding MRNA Binding Signaling Receptor Binding Copper Ion Binding Protein Binding Enzyme Activator Activity Peptidase Activity Superoxide Dismutase Copper Chaperone Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Hydrolase Activity Oxygen Sensor Activity Enzyme Binding Kinase Binding Cytokine Binding Peptidase Inhibitor Activity Signaling Receptor Activator Activity Tyrosine 3-monooxygenase Activator Activity L-dopa Decarboxylase Activator Activity Protein Deglycase Activity Identical Protein Binding Protein Homodimerization Activity Small Protein Activating Enzyme Binding Ubiquitin-like Protein Conjugating Enzyme Binding Cadherin Binding Mercury Ion Binding Nuclear Androgen Receptor Binding Peroxiredoxin Activity Ubiquitin-protein Transferase Inhibitor Activity Scaffold Protein Binding DNA-binding Transcription Factor Binding Cupric Ion Binding Cuprous Ion Binding Ubiquitin-specific Protease Binding Glyoxalase (glycolic Acid-forming) Activity	RNA Binding Protein Binding Transcription Factor Binding Potassium Channel Regulator Activity Enzyme Binding Protein Tag Activity Ubiquitin Protein Ligase Binding Small Protein Activating Enzyme Binding Ubiquitin-like Protein Ligase Binding Transporter Activator Activity Ubiquitin-specific Protease Binding
	Biological Process	Synaptic Transmission, Dopaminergic Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus DNA Repair Proteolysis Autophagy Inflammatory Response DNA Damage Response Response To Oxidative Stress Mitochondrion Organization Ras Protein Signal Transduction Single Fertilization Adult Locomotory Behavior Methylglyoxal Metabolic Process Detoxification Of Copper Ion Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Lactate Biosynthetic Process Removal Of Superoxide Radicals Insulin Secretion Protein Repair Androgen Receptor Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of TRAIL Production Positive Regulation Of Interleukin-8 Production Negative Regulation Of Protein Sumoylation Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Cellular Response To Glyoxal Negative Regulation Of Protein Catabolic Process Response To Hydrogen Peroxide Glucose Homeostasis Hydrogen Peroxide Metabolic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Glycolate Biosynthetic Process Negative Regulation Of Protein Export From Nucleus Regulation Of Inflammatory Response Detoxification Of Mercury Ion Protein Stabilization Dopamine Uptake Involved In Synaptic Transmission Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Membrane Depolarization Membrane Hyperpolarization Regulation Of Androgen Receptor Signaling Pathway Detoxification Of Hydrogen Peroxide Methylglyoxal Catabolic Process To Lactate Cellular Response To Hydrogen Peroxide Detection Of Oxidative Stress Guanine Deglycation Guanine Deglycation, Methylglyoxal Removal Guanine Deglycation, Glyoxal Removal Cellular Detoxification Of Aldehyde Cellular Detoxification Of Methylglyoxal Positive Regulation Of Protein Localization To Nucleus Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Supramolecular Fiber Organization Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Death-inducing Signaling Complex Assembly Negative Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Dopamine Biosynthetic Process Glyoxal Metabolic Process Glyoxal Catabolic Process Positive Regulation Of L-dopa Biosynthetic Process Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Regulation Of DNA-templated Transcription Protein Sumoylation PML Body Organization Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Stability Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Cellular Response To Heat Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Action Potential Negative Regulation Of DNA-templated Transcription Protein Stabilization Roof Of Mouth Development Cellular Response To Cadmium Ion Regulation Of Cardiac Muscle Cell Contraction Protein Localization To Nuclear Pore Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Calcium Ion Transmembrane Transport
Pathways		SUMOylation of transcription cofactors Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins SUMOylation of DNA methylation proteins SUMOylation of DNA methylation proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Formation of Incision Complex in GG-NER Regulation of IFNG signaling Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Postmitotic nuclear pore complex (NPC) reformation Maturation of nucleoprotein Maturation of nucleoprotein SUMOylation of nuclear envelope proteins PKR-mediated signaling Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		Copper
Diseases		Parkinson's disease (PD)
GWAS		Behcet's disease ( 33393726) Blood protein levels ( 30072576) Celiac disease ( 20190752) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ischemic stroke ( 24262325) Ulcerative colitis ( 21297633 28067908)
Interacting Genes		25 interacting genes: BAX BBS1 BCL2L1 CASP8 COXFA4 CSN1S1 DAXX EFCAB6 FADD GOPC GPX4 HIPK1 HSPA5 MAPK8IP1 MAPKAPK5 PIAS2 PINK1 PPP2R1A PPP2R1B PRKACA SNCA SOD1 SUMO1 UBA2 UBE2I	154 interacting genes: AR ARK2N ARRB2 ATF2 ATXN1 ATXN3 ATXN7 AXIN1 BIRC3 BLM BRCA1 BTBD3 C11orf65 CANX CARD9 CASP2 CASP8 CCR2 CDK6 CEBPA CHAF1A CHD3 CREBBP DAXX DEUP1 DNM1 DNMT3B DTX2 EDARADD EGLN3 EIF2AK2 ERCC6 ETV6 FAF1 FAM118B FAS FASLG FBF1 FOS FOXM1 GMCL1 HDAC4 HDAC9 HGS HIF1A HIPK2 HIPK3 HNRNPC HNRNPK HSF1 HTT IKZF3 IRAK1 ISG15 JUN MAPK1IP1L MDM2 MEF2A MITF MRE11 MRTFA MSX1 MTOR MUL1 MYB NCOA1 NCOA2 NCOA3 NCOR2 NFE2L2 NFKBIA NIN NR3C1 NR3C2 PARK7 PAX6 PCNA PDGFC PHC1 PIAS1 PIAS2 PIAS3 PIAS4 PKM PLAGL1 PML PPM1J PRKN PROP1 PSIP1 RAD51 RAD52 RAD54B RAD54L2 RANBP2 RANGAP1 RHOXF2 RNF111 RNF167 RNF4 RPS3 SALL1 SATB1 SENP1 SENP2 SENP6 SETX SLC2A1 SMARCAD1 SOX10 SOX2 SOX6 SP100 SP3 SPOP SREBF1 SREBF2 SUMO1P1 TDG TDP2 TFCP2 TMIE TNFRSF1A TOE1 TOP1 TOP2A TOP2B TOPORS TP53 TP73 TRAF2 TRAF4 TRAF5 TRIM24 TRPS1 TSC22D3 UBA2 UBE2I USP25 USPL1 WRN ZBED1 ZBTB16 ZBTB2 ZBTB26 ZBTB6 ZCCHC12 ZCCHC7 ZFP42 ZHX1 ZMYM2 ZMYM3 ZMYM5 ZNF451
Entrez ID		11315	7341
HPRD ID		03961	03554
Ensembl ID		ENSG00000116288	ENSG00000116030
Uniprot IDs		Q99497 V9HWC2	B8ZZN6 B9A032 P63165
PDB IDs		1J42 1P5F 1PDV 1PDW 1PE0 1Q2U 1SOA 1UCF 2OR3 2R1T 2R1U 2R1V 2RK3 2RK4 2RK6 3B36 3B38 3B3A 3BWE 3CY6 3CYF 3CZ9 3CZA 3EZG 3F71 3SF8 4BTE 4MNT 4MTC 4N0M 4N12 4OGF 4OQ4 4P2G 4P34 4P35 4P36 4RKW 4RKY 4S0Z 4ZGG 5IP5 5SY6 5SY9 5SYA 6AF5 6AF7 6AF9 6AFA 6AFB 6AFC 6AFD 6AFE 6AFF 6AFG 6AFH 6AFI 6AFJ 6AFL 6E5Z 6M8Z 7C62 7PA2 7PA3 8PPW 8PQ0 9CEI 9CFI 9CFM 9CFO 9CFQ 9CFY 9CFZ 9CG0 9CGA 9CGB 9CGD 9CGE 9CGF 9CGG 9CMX 9CMY	1A5R 1TGZ 1WYW 1Y8R 1Z5S 2ASQ 2BF8 2G4D 2IO2 2IY0 2IY1 2KQS 2LAS 2MW5 2N1A 2N1V 2PE6 2UYZ 2VRR 3KYC 3KYD 3RZW 3UIP 4WJN 4WJO 4WJP 4WJQ 5AEK 5B7A 5ELJ 5GHD 6EOP 6EOT 6J4I 6JXU 6JXV 6K5T 6TRW 6UYO 6UYP 6UYQ 6UYR 6UYS 6UYT 6UYU 6UYV 6UYX 6UYY 6UYZ 6V7P 6V7Q 6V7R 6V7S 6WW3 6XOG 6XOH 6XOI 8DJH 8DJI 8ODR 9B62
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway Small Protein Activating Enzyme Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Cellular Response To Stress Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Ubiquitin Protein Ligase Binding Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Programmed Cell Death Cell Death PML Body Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Intracellular Signal Transduction Protein Sumoylation Response To Stress Mitochondrion Regulation Of Intracellular Signal Transduction Regulation Of Neuron Apoptotic Process Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Cellular Response To Cadmium Ion Regulation Of Mitochondrial Membrane Potential Programmed Cell Death Involved In Cell Development Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Metabolic Process Cytoplasm Nucleus Apoptotic Signaling Pathway Response To Heat Regulation Of Intrinsic Apoptotic Signaling Pathway Protein-containing Complex Mitochondrial Outer Membrane Death Effector Domain Binding Meiotic Sister Chromatid Cohesion, Centromeric Cytosol Response To Copper Ion Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Enzyme Binding Intracellular Signal Transduction Positive Regulation Of Cell Communication	Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process PML Body Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Protein Sumoylation Positive Regulation Of DNA-templated Transcription Cellular Response To Stress Positive Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Transcription By RNA Polymerase II SUMO Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Chromatin Binding DNA Damage Response Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Protein Modification By Small Protein Conjugation Post-translational Protein Modification Macromolecule Metabolic Process Response To Stress DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nuclear Body Protein-containing Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding
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