PARK7 and SOD1

Number of citations of the paper that reports this interaction (PubMedID 31536960)
63

Data Source:
BioGRID (affinity chromatography technology, biochemical, affinity chromatography technology, protein complementation assay)

		PARK7	SOD1
Description		Parkinsonism associated deglycase	superoxide dismutase 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Endoplasmic Reticulum Cytosol Plasma Membrane Adherens Junction Synaptic Vesicle Membrane PML Body Axon Neuron Projection Cell Body Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Lysosome Peroxisome Cytosol Plasma Membrane Secretory Granule Dense Core Granule Cytoplasmic Vesicle Dendrite Cytoplasm Protein-containing Complex Neuronal Cell Body Extracellular Exosome Axon Cytoplasm
	Molecular Function	Core Promoter Sequence-specific DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding MRNA Binding Signaling Receptor Binding Copper Ion Binding Protein Binding Enzyme Activator Activity Peptidase Activity Superoxide Dismutase Copper Chaperone Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Hydrolase Activity Oxygen Sensor Activity Enzyme Binding Kinase Binding Cytokine Binding Peptidase Inhibitor Activity Signaling Receptor Activator Activity Tyrosine 3-monooxygenase Activator Activity L-dopa Decarboxylase Activator Activity Protein Deglycase Activity Identical Protein Binding Protein Homodimerization Activity Small Protein Activating Enzyme Binding Ubiquitin-like Protein Conjugating Enzyme Binding Cadherin Binding Mercury Ion Binding Nuclear Androgen Receptor Binding Peroxiredoxin Activity Ubiquitin-protein Transferase Inhibitor Activity Scaffold Protein Binding DNA-binding Transcription Factor Binding Cupric Ion Binding Cuprous Ion Binding Ubiquitin-specific Protease Binding Glyoxalase (glycolic Acid-forming) Activity	Superoxide Dismutase Activity Copper Ion Binding Protein Binding Zinc Ion Binding Antioxidant Activity Oxidoreductase Activity Enzyme Binding Protein Phosphatase 2B Binding Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein-folding Chaperone Binding
	Biological Process	Synaptic Transmission, Dopaminergic Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus DNA Repair Proteolysis Autophagy Inflammatory Response DNA Damage Response Response To Oxidative Stress Mitochondrion Organization Ras Protein Signal Transduction Single Fertilization Adult Locomotory Behavior Methylglyoxal Metabolic Process Detoxification Of Copper Ion Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Lactate Biosynthetic Process Removal Of Superoxide Radicals Insulin Secretion Protein Repair Androgen Receptor Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of TRAIL Production Positive Regulation Of Interleukin-8 Production Negative Regulation Of Protein Sumoylation Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Cellular Response To Glyoxal Negative Regulation Of Protein Catabolic Process Response To Hydrogen Peroxide Glucose Homeostasis Hydrogen Peroxide Metabolic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Glycolate Biosynthetic Process Negative Regulation Of Protein Export From Nucleus Regulation Of Inflammatory Response Detoxification Of Mercury Ion Protein Stabilization Dopamine Uptake Involved In Synaptic Transmission Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Membrane Depolarization Membrane Hyperpolarization Regulation Of Androgen Receptor Signaling Pathway Detoxification Of Hydrogen Peroxide Methylglyoxal Catabolic Process To Lactate Cellular Response To Hydrogen Peroxide Detection Of Oxidative Stress Guanine Deglycation Guanine Deglycation, Methylglyoxal Removal Guanine Deglycation, Glyoxal Removal Cellular Detoxification Of Aldehyde Cellular Detoxification Of Methylglyoxal Positive Regulation Of Protein Localization To Nucleus Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Supramolecular Fiber Organization Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Death-inducing Signaling Complex Assembly Negative Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Dopamine Biosynthetic Process Glyoxal Metabolic Process Glyoxal Catabolic Process Positive Regulation Of L-dopa Biosynthetic Process Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Response To Reactive Oxygen Species Response To Superoxide Ovarian Follicle Development Positive Regulation Of Cytokine Production Placenta Development Retina Homeostasis Response To Amphetamine Myeloid Cell Homeostasis Glutathione Metabolic Process Superoxide Metabolic Process Intracellular Iron Ion Homeostasis Apoptotic Process Response To Oxidative Stress Spermatogenesis Embryo Implantation Sensory Perception Of Sound Locomotory Behavior Anterograde Axonal Transport Retrograde Axonal Transport Regulation Of Blood Pressure Determination Of Adult Lifespan Response To Heat Response To Xenobiotic Stimulus Gene Expression Transmission Of Nerve Impulse Neuronal Action Potential Removal Of Superoxide Radicals Response To Nutrient Levels Peripheral Nervous System Myelin Maintenance Positive Regulation Of Superoxide Anion Generation Regulation Of T Cell Differentiation In Thymus Response To Carbon Monoxide Cellular Response To Oxidative Stress Ectopic Germ Cell Programmed Cell Death Cellular Response To Potassium Ion Regulation Of Multicellular Organism Growth Response To Hydrogen Peroxide Superoxide Anion Generation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Regulation Of Organ Growth Response To Copper Ion Muscle Cell Cellular Homeostasis Thymus Development Response To Axon Injury Hydrogen Peroxide Biosynthetic Process Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Negative Regulation Of Developmental Process Regulation Of Mitochondrial Membrane Potential Heart Contraction Neurofilament Cytoskeleton Organization Relaxation Of Vascular Associated Smooth Muscle Auditory Receptor Cell Stereocilium Organization Cellular Response To Cadmium Ion Cellular Response To ATP Reactive Oxygen Species Metabolic Process Response To Antipsychotic Drug Action Potential Initiation Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reproductive Process
Pathways		SUMOylation of transcription cofactors Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Platelet degranulation Detoxification of Reactive Oxygen Species Detoxification of Reactive Oxygen Species Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Copper	Dopamine Isoprenaline Zinc 5-fluorouridine S-oxy-L-cysteine Arimoclomol Cannabidiol Benzoyl peroxide Medical Cannabis Nabiximols Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Parkinson's disease (PD)	Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Behcet's disease ( 33393726) Blood protein levels ( 30072576) Celiac disease ( 20190752) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ischemic stroke ( 24262325) Ulcerative colitis ( 21297633 28067908)	Amyotrophic lateral sclerosis ( 20801718)
Interacting Genes		25 interacting genes: BAX BBS1 BCL2L1 CASP8 COXFA4 CSN1S1 DAXX EFCAB6 FADD GOPC GPX4 HIPK1 HSPA5 MAPK8IP1 MAPKAPK5 PIAS2 PINK1 PPP2R1A PPP2R1B PRKACA SNCA SOD1 SUMO1 UBA2 UBE2I	18 interacting genes: AMFR BCL2 CCS COMMD1 CRYAB DNAJB1 FNDC3B HOXB2 KARS1 MARCHF5 MYCBP2 PARK7 PAX6 PPP3CA RANBP9 RNF19A SMAD2 UBE3A
Entrez ID		11315	6647
HPRD ID		03961	00937
Ensembl ID		ENSG00000116288	ENSG00000142168
Uniprot IDs		Q99497 V9HWC2	P00441 V9HWC9
PDB IDs		1J42 1P5F 1PDV 1PDW 1PE0 1Q2U 1SOA 1UCF 2OR3 2R1T 2R1U 2R1V 2RK3 2RK4 2RK6 3B36 3B38 3B3A 3BWE 3CY6 3CYF 3CZ9 3CZA 3EZG 3F71 3SF8 4BTE 4MNT 4MTC 4N0M 4N12 4OGF 4OQ4 4P2G 4P34 4P35 4P36 4RKW 4RKY 4S0Z 4ZGG 5IP5 5SY6 5SY9 5SYA 6AF5 6AF7 6AF9 6AFA 6AFB 6AFC 6AFD 6AFE 6AFF 6AFG 6AFH 6AFI 6AFJ 6AFL 6E5Z 6M8Z 7C62 7PA2 7PA3 8PPW 8PQ0 9CEI 9CFI 9CFM 9CFO 9CFQ 9CFY 9CFZ 9CG0 9CGA 9CGB 9CGD 9CGE 9CGF 9CGG 9CMX 9CMY	1AZV 1BA9 1DSW 1FUN 1HL4 1HL5 1KMG 1L3N 1MFM 1N18 1N19 1OEZ 1OZT 1OZU 1P1V 1PTZ 1PU0 1RK7 1SOS 1SPD 1UXL 1UXM 2AF2 2C9S 2C9U 2C9V 2GBT 2GBU 2GBV 2LU5 2MP3 2NAM 2NNX 2R27 2V0A 2VR6 2VR7 2VR8 2WKO 2WYT 2WYZ 2WZ0 2WZ5 2WZ6 2XJK 2XJL 2ZKW 2ZKX 2ZKY 3CQP 3CQQ 3ECU 3ECV 3ECW 3GQF 3GTV 3GZO 3GZP 3GZQ 3H2P 3H2Q 3HFF 3K91 3KH3 3KH4 3LTV 3QQD 3RE0 3T5W 4A7G 4A7Q 4A7S 4A7T 4A7U 4A7V 4B3E 4BCY 4BCZ 4BD4 4FF9 4MCM 4MCN 4NIN 4NIO 4NIP 4OH2 4XCR 5DLI 5IIW 5J07 5J0C 5J0F 5J0G 5K02 5O3Y 5O40 5U9M 5WMJ 5WOR 5YTO 5YTU 5YUL 6A9O 6B79 6DTK 6FFK 6FLH 6FOI 6FOL 6FON 6FP6 6SPA 6SPH 6SPI 6SPJ 6SPK 6Z3V 6Z4G 6Z4H 6Z4I 6Z4J 6Z4K 6Z4L 6Z4M 6Z4O 7CJV 7CJW 7FB6 7FB9 7NXX 7T8E 7T8F 7T8G 7T8H 7VZF 7XX3 8CCX 8GSQ 8IHU 8IHV 8K33 8K3A 8K3L 8Q6M 8YAT 8YD3 9IYK 9JBO 9JBP
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway Small Protein Activating Enzyme Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Cellular Response To Stress Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Ubiquitin Protein Ligase Binding Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Programmed Cell Death Cell Death PML Body Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Intracellular Signal Transduction Protein Sumoylation Response To Stress Mitochondrion Regulation Of Intracellular Signal Transduction Regulation Of Neuron Apoptotic Process Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Cellular Response To Cadmium Ion Regulation Of Mitochondrial Membrane Potential Programmed Cell Death Involved In Cell Development Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Metabolic Process Cytoplasm Nucleus Apoptotic Signaling Pathway Response To Heat Regulation Of Intrinsic Apoptotic Signaling Pathway Protein-containing Complex Mitochondrial Outer Membrane Death Effector Domain Binding Meiotic Sister Chromatid Cohesion, Centromeric Cytosol Response To Copper Ion Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Enzyme Binding Intracellular Signal Transduction Positive Regulation Of Cell Communication	Protein K48-linked Ubiquitination Superoxide Dismutase Copper Chaperone Activity Cytosol Protein Polyubiquitination Post-translational Protein Modification Organ Growth Copper Ion Binding Ubiquitin Protein Ligase Activity Intracellular Signal Transduction Protein Autoubiquitination Identical Protein Binding Protein Ubiquitination Cytoplasm Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Co-SMAD Binding Regulation Of Protein Ubiquitination Negative Regulation Of Signal Transduction Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Protein Metabolic Process Negative Regulation Of Transport Positive Regulation Of Inflammatory Response To Antigenic Stimulus Dorsal/ventral Axis Specification Removal Of Superoxide Radicals Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Post-translational Protein Modification Protein K27-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Reactive Oxygen Species Metabolic Process Ubiquitin-specific Protease Binding Response To Hydrogen Peroxide Negative Regulation Of Monoatomic Ion Transport Neuron Projection Morphogenesis Ubiquitin Ligase Complex Cell Projection Morphogenesis Mitochondrion Positive Regulation Of Protein Ubiquitination Protein Modification Process Androgen Receptor Signaling Pathway Regulation Of Cellular Response To Stress Negative Regulation Of Transmembrane Transport Intracellular Signaling Cassette Embryonic Organ Morphogenesis R-SMAD Binding Positive Regulation Of Post-translational Protein Modification Skeletal Muscle Fiber Development Gland Morphogenesis Response To Ionizing Radiation
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