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PARK7 and PPP2R1A
Number of citations of the paper that reports this interaction (PubMedID
17540176
)
58
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
PARK7
PPP2R1A
Description
Parkinsonism associated deglycase
protein phosphatase 2 scaffold subunit Aalpha
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Intermembrane Space
Mitochondrial Matrix
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Adherens Junction
Synaptic Vesicle
Membrane
PML Body
Axon
Neuron Projection
Cell Body
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Chromatin
Nucleus
Chromosome
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Microtubule Cytoskeleton
Membrane
Lateral Plasma Membrane
Dendrite
Cell Projection
Neuron Projection
Neuronal Cell Body
Synapse
Extracellular Exosome
FAR/SIN/STRIPAK Complex
Glutamatergic Synapse
INTAC Complex
Molecular Function
Core Promoter Sequence-specific DNA Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Transcription Coactivator Activity
RNA Binding
MRNA Binding
Signaling Receptor Binding
Copper Ion Binding
Protein Binding
Enzyme Activator Activity
Peptidase Activity
Superoxide Dismutase Copper Chaperone Activity
Oxidoreductase Activity, Acting On Peroxide As Acceptor
Hydrolase Activity
Oxygen Sensor Activity
Enzyme Binding
Kinase Binding
Cytokine Binding
Peptidase Inhibitor Activity
Signaling Receptor Activator Activity
Tyrosine 3-monooxygenase Activator Activity
L-dopa Decarboxylase Activator Activity
Protein Deglycase Activity
Identical Protein Binding
Protein Homodimerization Activity
Small Protein Activating Enzyme Binding
Ubiquitin-like Protein Conjugating Enzyme Binding
Cadherin Binding
Mercury Ion Binding
Nuclear Androgen Receptor Binding
Peroxiredoxin Activity
Ubiquitin-protein Transferase Inhibitor Activity
Scaffold Protein Binding
DNA-binding Transcription Factor Binding
Cupric Ion Binding
Cuprous Ion Binding
Ubiquitin-specific Protease Binding
Glyoxalase (glycolic Acid-forming) Activity
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein Phosphatase Regulator Activity
Protein Heterodimerization Activity
Protein Antigen Binding
Biological Process
Synaptic Transmission, Dopaminergic
Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus
DNA Repair
Proteolysis
Autophagy
Inflammatory Response
DNA Damage Response
Response To Oxidative Stress
Mitochondrion Organization
Ras Protein Signal Transduction
Single Fertilization
Adult Locomotory Behavior
Methylglyoxal Metabolic Process
Detoxification Of Copper Ion
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Lactate Biosynthetic Process
Removal Of Superoxide Radicals
Insulin Secretion
Protein Repair
Androgen Receptor Signaling Pathway
Positive Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Protein Ubiquitination
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of TRAIL Production
Positive Regulation Of Interleukin-8 Production
Negative Regulation Of Protein Sumoylation
Cellular Response To Oxidative Stress
Cellular Response To Reactive Oxygen Species
Cellular Response To Glyoxal
Negative Regulation Of Protein Catabolic Process
Response To Hydrogen Peroxide
Glucose Homeostasis
Hydrogen Peroxide Metabolic Process
Regulation Of Neuron Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Transcription By RNA Polymerase II
Glycolate Biosynthetic Process
Negative Regulation Of Protein Export From Nucleus
Regulation Of Inflammatory Response
Detoxification Of Mercury Ion
Protein Stabilization
Dopamine Uptake Involved In Synaptic Transmission
Regulation Of Mitochondrial Membrane Potential
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Membrane Depolarization
Membrane Hyperpolarization
Regulation Of Androgen Receptor Signaling Pathway
Detoxification Of Hydrogen Peroxide
Methylglyoxal Catabolic Process To Lactate
Cellular Response To Hydrogen Peroxide
Detection Of Oxidative Stress
Guanine Deglycation
Guanine Deglycation, Methylglyoxal Removal
Guanine Deglycation, Glyoxal Removal
Cellular Detoxification Of Aldehyde
Cellular Detoxification Of Methylglyoxal
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Synaptic Vesicle Endocytosis
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Regulation Of Supramolecular Fiber Organization
Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone
Negative Regulation Of Death-inducing Signaling Complex Assembly
Negative Regulation Of Protein K48-linked Deubiquitination
Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway
Positive Regulation Of Dopamine Biosynthetic Process
Glyoxal Metabolic Process
Glyoxal Catabolic Process
Positive Regulation Of L-dopa Biosynthetic Process
Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Positive Regulation Of Autophagy Of Mitochondrion
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide
Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Transcription By RNA Polymerase II
Transcription Elongation By RNA Polymerase II
Chromosome Segregation
Female Meiotic Nuclear Division
Negative Regulation Of Hippo Signaling
Intracellular Signal Transduction
Regulation Of Growth
T Cell Homeostasis
Regulation Of Cell Differentiation
Spindle Assembly
Meiotic Spindle Elongation
Mitotic Sister Chromatid Separation
Meiotic Sister Chromatid Cohesion, Centromeric
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein-containing Complex Assembly
RNA Polymerase II Transcription Initiation Surveillance
Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
SUMOylation of transcription cofactors
Chaperone Mediated Autophagy
Late endosomal microautophagy
Aggrephagy
Aggrephagy
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Initiation of Nuclear Envelope (NE) Reformation
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Co-stimulation by CD28
Co-inhibition by CTLA4
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
AURKA Activation by TPX2
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
PKR-mediated signaling
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Copper
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
Parkinson's disease (PD)
GWAS
Behcet's disease (
33393726
)
Blood protein levels (
30072576
)
Celiac disease (
20190752
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Ischemic stroke (
24262325
)
Ulcerative colitis (
21297633
28067908
)
Interacting Genes
25 interacting genes:
BAX
BBS1
BCL2L1
CASP8
COXFA4
CSN1S1
DAXX
EFCAB6
FADD
GOPC
GPX4
HIPK1
HSPA5
MAPK8IP1
MAPKAPK5
PIAS2
PINK1
PPP2R1A
PPP2R1B
PRKACA
SNCA
SOD1
SUMO1
UBA2
UBE2I
59 interacting genes:
AIMP2
AKT1
AMOTL2
ARIH2
ATM
CARD11
CARHSP1
CDC42
CDK1
CSDC2
CSNK2B
DAPK1
DELEC1
DUX4
EEF2
ESR1
FBXO43
GNA12
GOLGA6A
GOLGA8F
GRIN1
GRIN2D
HSF2
HSPD1
IPO9
LINC01554
MAP3K7
MAPK6
MCM3
OGT
PARK7
PLAAT3
PPP2CA
PPP2R2A
PPP2R3B
PPP2R5A
PPP2R5B
PPP4C
PPP5C
PRDX1
PRDX2
PTPA
RAB11A
RAB18
RAB7A
RAP1A
RORC
SGO1
SGO2
SLC25A21-AS1
SLC6A2
SMAD2
SMAD3
STRN
STRN3
SUMO2
TAB1
TRADD
ZFYVE9
Entrez ID
11315
5518
HPRD ID
03961
16184
Ensembl ID
ENSG00000116288
ENSG00000105568
Uniprot IDs
Q99497
V9HWC2
A8K7B7
B3KQV6
P30153
PDB IDs
1J42
1P5F
1PDV
1PDW
1PE0
1Q2U
1SOA
1UCF
2OR3
2R1T
2R1U
2R1V
2RK3
2RK4
2RK6
3B36
3B38
3B3A
3BWE
3CY6
3CYF
3CZ9
3CZA
3EZG
3F71
3SF8
4BTE
4MNT
4MTC
4N0M
4N12
4OGF
4OQ4
4P2G
4P34
4P35
4P36
4RKW
4RKY
4S0Z
4ZGG
5IP5
5SY6
5SY9
5SYA
6AF5
6AF7
6AF9
6AFA
6AFB
6AFC
6AFD
6AFE
6AFF
6AFG
6AFH
6AFI
6AFJ
6AFL
6E5Z
6M8Z
7C62
7PA2
7PA3
8PPW
8PQ0
9CEI
9CFI
9CFM
9CFO
9CFQ
9CFY
9CFZ
9CG0
9CGA
9CGB
9CGD
9CGE
9CGF
9CGG
9CMX
9CMY
1B3U
2IE3
2IE4
2NPP
2NYL
2NYM
2PKG
3C5W
3DW8
3K7V
3K7W
4I5L
4I5N
4LAC
5W0W
6IUR
6NTS
7CUN
7K36
7PKS
7SOY
7YCX
8RBX
8RBZ
8RC4
8SO0
8TTB
8TWE
8TWI
8U1X
8U89
8UWB
8YJB
Enriched GO Terms of Interacting Partners
?
Extrinsic Apoptotic Signaling Pathway
Small Protein Activating Enzyme Binding
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Signaling Pathway
Cellular Response To Stress
Apoptotic Process
Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Ubiquitin Protein Ligase Binding
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Programmed Cell Death
Cell Death
PML Body
Regulation Of Signal Transduction
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Intracellular Signal Transduction
Protein Sumoylation
Response To Stress
Mitochondrion
Regulation Of Intracellular Signal Transduction
Regulation Of Neuron Apoptotic Process
Ectopic Germ Cell Programmed Cell Death
Positive Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Signal Transduction
Cellular Response To Cadmium Ion
Regulation Of Mitochondrial Membrane Potential
Programmed Cell Death Involved In Cell Development
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Signaling
Regulation Of Cell Communication
Negative Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Protein Metabolic Process
Cytoplasm
Nucleus
Apoptotic Signaling Pathway
Response To Heat
Regulation Of Intrinsic Apoptotic Signaling Pathway
Protein-containing Complex
Mitochondrial Outer Membrane
Death Effector Domain Binding
Meiotic Sister Chromatid Cohesion, Centromeric
Cytosol
Response To Copper Ion
Neuron Apoptotic Process
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Enzyme Binding
Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Protein Phosphatase Type 2A Complex
Intracellular Signal Transduction
Intracellular Signaling Cassette
Cytosol
Protein Phosphatase 2A Binding
Cytoplasm
Protein Phosphatase Regulator Activity
Signal Transduction
Peroxiredoxin Activity
Cellular Response To Oxygen-containing Compound
Canonical NF-kappaB Signal Transduction
Regulation Of Signal Transduction
Glutamatergic Synapse
Response To Oxidative Stress
G Protein Activity
Positive Regulation Of Signal Transduction
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein-containing Complex
Regulation Of Cell Communication
Regulation Of Signaling
Response To Growth Factor
Cellular Response To Nerve Growth Factor Stimulus
Tau Protein Binding
Response To Nerve Growth Factor
Removal Of Superoxide Radicals
Response To Reactive Oxygen Species
Positive Regulation Of Cell Communication
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Signaling
Kinase Binding
Positive Regulation Of Intracellular Signal Transduction
Cell Population Proliferation
Regulation Of Programmed Cell Death
Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway
Regulation Of Intracellular Signal Transduction
Protein-containing Complex Binding
GTP Binding
Protein Phosphatase Activator Activity
Phosphatase Binding
Paraxial Mesoderm Morphogenesis
Transforming Growth Factor Beta Receptor Signaling Pathway
FAR/SIN/STRIPAK Complex
Regulation Of Protein Catabolic Process
Cellular Response To Growth Factor Stimulus
Peptidyl-threonine Phosphorylation
Calmodulin Binding
Protein Metabolic Process
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cellular Localization
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