PARK7 and GPX4

Number of citations of the paper that reports this interaction (PubMedID 18626009)
35

Data Source:
BioGRID (unspecified method)

		PARK7	GPX4
Description		Parkinsonism associated deglycase	glutathione peroxidase 4
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Endoplasmic Reticulum Cytosol Plasma Membrane Adherens Junction Synaptic Vesicle Membrane PML Body Axon Neuron Projection Cell Body Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Nuclear Envelope Cytoplasm Mitochondrion Cytosol Protein-containing Complex Extracellular Exosome
	Molecular Function	Core Promoter Sequence-specific DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding MRNA Binding Signaling Receptor Binding Copper Ion Binding Protein Binding Enzyme Activator Activity Peptidase Activity Superoxide Dismutase Copper Chaperone Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Hydrolase Activity Oxygen Sensor Activity Enzyme Binding Kinase Binding Cytokine Binding Peptidase Inhibitor Activity Signaling Receptor Activator Activity Tyrosine 3-monooxygenase Activator Activity L-dopa Decarboxylase Activator Activity Protein Deglycase Activity Identical Protein Binding Protein Homodimerization Activity Small Protein Activating Enzyme Binding Ubiquitin-like Protein Conjugating Enzyme Binding Cadherin Binding Mercury Ion Binding Nuclear Androgen Receptor Binding Peroxiredoxin Activity Ubiquitin-protein Transferase Inhibitor Activity Scaffold Protein Binding DNA-binding Transcription Factor Binding Cupric Ion Binding Cuprous Ion Binding Ubiquitin-specific Protease Binding Glyoxalase (glycolic Acid-forming) Activity	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Selenium Binding Oxidoreductase Activity Identical Protein Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity
	Biological Process	Synaptic Transmission, Dopaminergic Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus DNA Repair Proteolysis Autophagy Inflammatory Response DNA Damage Response Response To Oxidative Stress Mitochondrion Organization Ras Protein Signal Transduction Single Fertilization Adult Locomotory Behavior Methylglyoxal Metabolic Process Detoxification Of Copper Ion Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Lactate Biosynthetic Process Removal Of Superoxide Radicals Insulin Secretion Protein Repair Androgen Receptor Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of TRAIL Production Positive Regulation Of Interleukin-8 Production Negative Regulation Of Protein Sumoylation Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Cellular Response To Glyoxal Negative Regulation Of Protein Catabolic Process Response To Hydrogen Peroxide Glucose Homeostasis Hydrogen Peroxide Metabolic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Glycolate Biosynthetic Process Negative Regulation Of Protein Export From Nucleus Regulation Of Inflammatory Response Detoxification Of Mercury Ion Protein Stabilization Dopamine Uptake Involved In Synaptic Transmission Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Membrane Depolarization Membrane Hyperpolarization Regulation Of Androgen Receptor Signaling Pathway Detoxification Of Hydrogen Peroxide Methylglyoxal Catabolic Process To Lactate Cellular Response To Hydrogen Peroxide Detection Of Oxidative Stress Guanine Deglycation Guanine Deglycation, Methylglyoxal Removal Guanine Deglycation, Glyoxal Removal Cellular Detoxification Of Aldehyde Cellular Detoxification Of Methylglyoxal Positive Regulation Of Protein Localization To Nucleus Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Supramolecular Fiber Organization Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Death-inducing Signaling Complex Assembly Negative Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Dopamine Biosynthetic Process Glyoxal Metabolic Process Glyoxal Catabolic Process Positive Regulation Of L-dopa Biosynthetic Process Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Chromatin Organization Lipid Metabolic Process Phospholipid Metabolic Process Apoptotic Process Response To Oxidative Stress Spermatogenesis Dendrite Development Arachidonate Metabolic Process Lipoxygenase Pathway Cerebellum Development Response To Estradiol Response To Lipopolysaccharide Multicellular Organism Growth Long-chain Fatty Acid Biosynthetic Process Protein Polymerization Cellular Oxidant Detoxification Negative Regulation Of Ferroptosis
Pathways		SUMOylation of transcription cofactors Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives
Drugs		Copper	Glutathione Glutathione Glutathione disulfide Benzoyl peroxide
Diseases		Parkinson's disease (PD)
GWAS		Behcet's disease ( 33393726) Blood protein levels ( 30072576) Celiac disease ( 20190752) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ischemic stroke ( 24262325) Ulcerative colitis ( 21297633 28067908)	Advanced age-related macular degeneration ( 26691988) Asthma (childhood onset) ( 31036433) Basal cell carcinoma ( 31174203) Crohn's disease ( 23128233 21102463 28067908) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) hemolysis of donated blood (oxidative) ( 34014839) Inflammatory bowel disease ( 28067908) Keratinocyte cancer (MTAG) ( 31174203) Liver enzyme levels (alkaline phosphatase) ( 33972514) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		25 interacting genes: BAX BBS1 BCL2L1 CASP8 COXFA4 CSN1S1 DAXX EFCAB6 FADD GOPC GPX4 HIPK1 HSPA5 MAPK8IP1 MAPKAPK5 PIAS2 PINK1 PPP2R1A PPP2R1B PRKACA SNCA SOD1 SUMO1 UBA2 UBE2I	5 interacting genes: MAPK13 PARK7 PRDX6 RNF31 SNRNP48
Entrez ID		11315	2879
HPRD ID		03961	11819
Ensembl ID		ENSG00000116288	ENSG00000167468
Uniprot IDs		Q99497 V9HWC2	P36969 Q6PI42
PDB IDs		1J42 1P5F 1PDV 1PDW 1PE0 1Q2U 1SOA 1UCF 2OR3 2R1T 2R1U 2R1V 2RK3 2RK4 2RK6 3B36 3B38 3B3A 3BWE 3CY6 3CYF 3CZ9 3CZA 3EZG 3F71 3SF8 4BTE 4MNT 4MTC 4N0M 4N12 4OGF 4OQ4 4P2G 4P34 4P35 4P36 4RKW 4RKY 4S0Z 4ZGG 5IP5 5SY6 5SY9 5SYA 6AF5 6AF7 6AF9 6AFA 6AFB 6AFC 6AFD 6AFE 6AFF 6AFG 6AFH 6AFI 6AFJ 6AFL 6E5Z 6M8Z 7C62 7PA2 7PA3 8PPW 8PQ0 9CEI 9CFI 9CFM 9CFO 9CFQ 9CFY 9CFZ 9CG0 9CGA 9CGB 9CGD 9CGE 9CGF 9CGG 9CMX 9CMY	2GS3 2OBI 5H5Q 5H5R 5H5S 6ELW 6HKQ 6HN3 7L8K 7L8L 7L8M 7L8Q 7L8R 7U4I 7U4J 7U4K 7U4L 7U4M 7U4N 8Q8J 8Q8N
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway Small Protein Activating Enzyme Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Cellular Response To Stress Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Ubiquitin Protein Ligase Binding Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Programmed Cell Death Cell Death PML Body Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Intracellular Signal Transduction Protein Sumoylation Response To Stress Mitochondrion Regulation Of Intracellular Signal Transduction Regulation Of Neuron Apoptotic Process Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Cellular Response To Cadmium Ion Regulation Of Mitochondrial Membrane Potential Programmed Cell Death Involved In Cell Development Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Metabolic Process Cytoplasm Nucleus Apoptotic Signaling Pathway Response To Heat Regulation Of Intrinsic Apoptotic Signaling Pathway Protein-containing Complex Mitochondrial Outer Membrane Death Effector Domain Binding Meiotic Sister Chromatid Cohesion, Centromeric Cytosol Response To Copper Ion Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Enzyme Binding Intracellular Signal Transduction Positive Regulation Of Cell Communication	Peroxiredoxin Activity Transferase Activity Guanidinoacetate N-methyltransferase Activity Hydrogen Peroxide Metabolic Process Glyoxal Catabolic Process L-dopa Decarboxylase Activator Activity Guanine Deglycation Protein Deglycase Activity Glyoxalase (glycolic Acid-forming) Activity Glycolate Biosynthetic Process Guanine Deglycation, Methylglyoxal Removal Guanine Deglycation, Glyoxal Removal Detoxification Of Mercury Ion Negative Regulation Of Death-inducing Signaling Complex Assembly Cellular Response To Glyoxal Glyoxal Metabolic Process Positive Regulation Of L-dopa Biosynthetic Process Tyrosine 3-monooxygenase Activator Activity 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase Activity Creatine Biosynthetic Process TFIIF-class Transcription Factor Complex Binding Transcription Factor TFIIF Complex Cellular Response To Sorbitol Cellular Response To Hydrogen Peroxide Cellular Oxidant Detoxification Negative Regulation Of Protein K48-linked Deubiquitination Detection Of Oxidative Stress Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Dopamine Biosynthetic Process Creatine Metabolic Process Cellular Response To Anisomycin Response To Oxidative Stress Reactive Oxygen Species Metabolic Process Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Superoxide Dismutase Copper Chaperone Activity Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Glycolate Metabolic Process Detoxification Of Hydrogen Peroxide Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of TRAIL Production Mercury Ion Binding Linear Polyubiquitin Binding Response To Hydrogen Peroxide Response To Anisomycin Cellular Response To Reactive Oxygen Species Response To Sorbitol Cellular Detoxification Cellular Detoxification Of Methylglyoxal Methylglyoxal Catabolic Process To Lactate
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