BSG and SLC16A13

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		BSG	SLC16A13
Name		basigin (Ok blood group)	solute carrier family 16 member 13
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Photoreceptor Outer Segment Photoreceptor Inner Segment Acrosomal Membrane Mitochondrion Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Membrane Basolateral Plasma Membrane Axon Sarcolemma Melanosome Cell Projection Extracellular Exosome	Golgi Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane
	Molecular Function	Virus Receptor Activity Protein Binding D-mannose Binding Carbohydrate Binding Signaling Receptor Activity Cadherin Binding Cell-cell Adhesion Mediator Activity	Protein Binding Monocarboxylic Acid Transmembrane Transporter Activity Symporter Activity Transmembrane Transporter Activity
	Biological Process	Angiogenesis Neural Retina Development Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell Surface Receptor Signaling Pathway Axon Guidance Embryo Implantation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Endothelial Cell Migration Neutrophil Chemotaxis Positive Regulation Of Interleukin-6 Production Odontogenesis Of Dentin-containing Tooth Response To Peptide Hormone Photoreceptor Cell Maintenance Positive Regulation Of Viral Entry Into Host Cell Response To Mercury Ion Decidualization Symbiont Entry Into Host Cell Response To CAMP Endothelial Tube Morphogenesis Dendrite Self-avoidance Protein Localization To Plasma Membrane Positive Regulation Of Matrix Metallopeptidase Secretion Neuron Projection Extension	Monocarboxylic Acid Transport Transmembrane Transport
Pathways		Degradation of the extracellular matrix Basigin interactions Integrin cell surface interactions Proton-coupled monocarboxylate transport Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) Aspirin ADME	None
GWAS		Alzheimer's disease (late onset) ( 28714976 )	Type 2 diabetes ( 23945395 24390345 26818947 )
Interacting Genes		21 interacting genes: ADRB2 AQP6 CACNA1C CAV1 CCR4 CHRM3 CRBN F2RL1 HGS MMP1 OGT PDLIM7 PPIA PPIL2 PPP2R1B SLC16A1 SLC16A13 SLC16A3 SLC2A4 TMEM14B UBC	19 interacting genes: AQP6 ATP13A1 BSG CCNDBP1 CD79A CREB3L1 FAM210B FXYD6-FXYD2 GJA8 HSD3B1 JPH1 PGRMC2 PTPN9 SHISAL1 SLC10A1 SYNDIG1 TMEM14B TMEM160 TMEM50B
Entrez ID		682	201232
HPRD ID		00176	18054
Ensembl ID		ENSG00000172270	ENSG00000174327
Uniprot IDs		P35613 Q54A51	Q7RTY0
PDB IDs		3B5H 3I84 3I85 3QQN 3QR2 4U0Q 5X0T 5XF0 6LYY 6LZ0 7CKO 7CKR 7DA5 7DAA 7DCE 7XY8 8XEJ	Not available
GO Terms Enriched among Interactors		Monocarboxylic Acid Transmembrane Transporter Activity Lactate:proton Symporter Activity Vascular Process In Circulatory System Plasma Membrane Lactate Transport Pyruvate Transmembrane Transport Pyruvate Transport Lactate Transmembrane Transporter Activity Regulation Of Muscle Contraction Regulation Of Transport Regulation Of Smooth Muscle Contraction Circulatory System Process Receptor-mediated Endocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transporter Activity Lactate Transport Pyruvate Catabolic Process Lactate Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cell Communication Positive Regulation Of Signaling Membrane Negative Regulation Of Post-translational Protein Modification Basolateral Plasma Membrane Regulation Of Muscle System Process System Process Symporter Activity Positive Regulation Of Cold-induced Thermogenesis Regulation Of Protein Secretion Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Signal Transduction Positive Regulation Of Secretion By Cell Regulation Of System Process Regulation Of Cardiac Muscle Cell Action Potential Negative Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Secretion Regulation Of Secretion By Cell Monocarboxylic Acid Transport Brown Fat Cell Differentiation Import Into Cell Blood Vessel Diameter Maintenance Regulation Of Cell Communication Positive Regulation Of Protein-containing Complex Disassembly G Protein-coupled Receptor Activity Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Apical Plasma Membrane Ligand-gated Ion Channel Signaling Pathway Regulation Of Cold-induced Thermogenesis Regulation Of Tube Size	None