BSG and SLC16A1

Number of citations of the paper that reports this interaction (PubMedID 10921872)
54

Data Source:
HPRD (in vivo, in vitro)

		BSG	SLC16A1
Description		basigin (Ok blood group)	solute carrier family 16 member 1
Image
GO Annotations	Cellular Component	Golgi Membrane Photoreceptor Outer Segment Photoreceptor Inner Segment Acrosomal Membrane Mitochondrion Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Membrane Basolateral Plasma Membrane Axon Sarcolemma Melanosome Cell Projection Extracellular Exosome	Centrosome Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Synapse Extracellular Exosome
	Molecular Function	Virus Receptor Activity Protein Binding D-mannose Binding Carbohydrate Binding Signaling Receptor Activity Cadherin Binding Cell-cell Adhesion Mediator Activity	Protein Binding Monocarboxylic Acid Transmembrane Transporter Activity Lactate Transmembrane Transporter Activity Mevalonate Transmembrane Transporter Activity Succinate Transmembrane Transporter Activity Symporter Activity Solute:proton Symporter Activity Secondary Active Monocarboxylate Transmembrane Transporter Activity Lactate:proton Symporter Activity Transmembrane Transporter Activity Identical Protein Binding Carboxylic Acid Transmembrane Transporter Activity
	Biological Process	Angiogenesis Neural Retina Development Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell Surface Receptor Signaling Pathway Axon Guidance Embryo Implantation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Endothelial Cell Migration Neutrophil Chemotaxis Positive Regulation Of Interleukin-6 Production Odontogenesis Of Dentin-containing Tooth Response To Peptide Hormone Photoreceptor Cell Maintenance Positive Regulation Of Viral Entry Into Host Cell Response To Mercury Ion Decidualization Symbiont Entry Into Host Cell Response To CAMP Endothelial Tube Morphogenesis Dendrite Self-avoidance Protein Localization To Plasma Membrane Positive Regulation Of Matrix Metallopeptidase Secretion Neuron Projection Extension	Lipid Metabolic Process Centrosome Cycle Monocarboxylic Acid Transport Mevalonate Transport Response To Food Lactate Transmembrane Transport Plasma Membrane Lactate Transport Glucose Homeostasis Pyruvate Catabolic Process Regulation Of Insulin Secretion Behavioral Response To Nutrient Transmembrane Transport Succinate Transmembrane Transport Transport Across Blood-brain Barrier Pyruvate Transmembrane Transport Proton Transmembrane Transport Carboxylic Acid Transmembrane Transport
Pathways		Degradation of the extracellular matrix Basigin interactions Integrin cell surface interactions Proton-coupled monocarboxylate transport Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) Aspirin ADME	Basigin interactions Proton-coupled monocarboxylate transport Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) Aspirin ADME
Drugs			Pyruvic acid Mersalyl
Diseases
GWAS		Alzheimer's disease (late onset) ( 28714976)	Macular thickness ( 30535121) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Refractive error ( 32231278)
Interacting Genes		21 interacting genes: ADRB2 AQP6 CACNA1C CAV1 CCR4 CHRM3 CRBN F2RL1 HGS MMP1 OGT PDLIM7 PPIA PPIL2 PPP2R1B SLC16A1 SLC16A13 SLC16A3 SLC2A4 TMEM14B UBC	3 interacting genes: AGTR1 BSG CRBN
Entrez ID		682	6566
HPRD ID		00176	02816
Ensembl ID		ENSG00000172270	ENSG00000155380
Uniprot IDs		P35613 Q54A51	B4DKS0 P53985
PDB IDs		3B5H 3I84 3I85 3QQN 3QR2 4U0Q 5X0T 5XF0 6LYY 6LZ0 7CKO 7CKR 7DA5 7DAA 7DCE 7XY8 8XEJ	6LYY 6LZ0 7CKO 7CKR 7DA5 7YR5
Enriched GO Terms of Interacting Partners?		Monocarboxylic Acid Transmembrane Transporter Activity Lactate:proton Symporter Activity Vascular Process In Circulatory System Plasma Membrane Lactate Transport Pyruvate Transmembrane Transport Pyruvate Transport Lactate Transmembrane Transporter Activity Regulation Of Muscle Contraction Regulation Of Transport Regulation Of Smooth Muscle Contraction Circulatory System Process Receptor-mediated Endocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transporter Activity Lactate Transport Pyruvate Catabolic Process Lactate Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cell Communication Positive Regulation Of Signaling Membrane Negative Regulation Of Post-translational Protein Modification Basolateral Plasma Membrane Regulation Of Muscle System Process System Process Symporter Activity Positive Regulation Of Cold-induced Thermogenesis Regulation Of Protein Secretion Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Signal Transduction Positive Regulation Of Secretion By Cell Regulation Of System Process Regulation Of Cardiac Muscle Cell Action Potential Negative Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Secretion Regulation Of Secretion By Cell Monocarboxylic Acid Transport Brown Fat Cell Differentiation Import Into Cell Blood Vessel Diameter Maintenance Regulation Of Cell Communication Positive Regulation Of Protein-containing Complex Disassembly G Protein-coupled Receptor Activity Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Apical Plasma Membrane Ligand-gated Ion Channel Signaling Pathway Regulation Of Cold-induced Thermogenesis Regulation Of Tube Size	Cell Chemotaxis Angiotensin Type I Receptor Activity Symbiont Entry Into Host Cell Biological Process Involved In Interaction With Host Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Positive Regulation Of Matrix Metallopeptidase Secretion Regulation Of Transport Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Locomotion Chemotaxis Regulation Of Renal Sodium Excretion Response To Mercury Ion Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Matrix Metallopeptidase Secretion Endothelial Tube Morphogenesis Positive Regulation Of Viral Entry Into Host Cell Cul4A-RING E3 Ubiquitin Ligase Complex Locomotory Exploration Behavior Low-density Lipoprotein Particle Remodeling Dendrite Self-avoidance Positive Regulation Of Macrophage Derived Foam Cell Differentiation Angiotensin-activated Signaling Pathway Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Secretion By Cell Neural Retina Development Regulation Of Secretion Regulation Of Viral Entry Into Host Cell D-mannose Binding Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Viral Life Cycle Decidualization Acrosomal Membrane Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Macrophage Derived Foam Cell Differentiation Exploration Behavior Plasma Lipoprotein Particle Remodeling Cell-cell Adhesion Mediator Activity Protein-containing Complex Remodeling Photoreceptor Cell Maintenance Positive Regulation Of Steroid Metabolic Process Cell Migration Regulation Of Systemic Arterial Blood Pressure Embryo Implantation Neuron Recognition
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