CD2BP2 and SNRPN

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid)

		CD2BP2	SNRPN
Name		CD2 cytoplasmic tail binding protein 2	small nuclear ribonucleoprotein polypeptide N
Structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm U5 SnRNP Cytoplasm Cytosol Nuclear Speck U4/U6 X U5 Tri-snRNP Complex	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP U1 SnRNP U2 SnRNP U4 SnRNP Cytoplasm Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Prespliceosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	Protein Binding Ribonucleoprotein Complex Binding	RNA Binding Protein Binding SnRNP Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly MRNA Processing RNA Splicing	MRNA Splicing, Via Spliceosome RNA Splicing
Pathways		None	mRNA Splicing - Major Pathway
Diseases		None	Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Brain morphology (MOSTest) ( 32665545 )	Aspartate aminotransferase levels ( 31219225 ) Carotid plaque burden ( 28282560 ) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862 ) Obesity-related traits ( 23251661 ) Panic disorder ( 31712720 ) Periodontal disease related phenotype (PCT5) ( 26962152 ) Periodontitis (DPAL) ( 24024966 ) Pulmonary function ( 17903307 )
Interacting Genes		22 interacting genes: ACAD11 AKNA AP2M1 CD2 CHRM3 CPSF7 CSNK2A1 LRRK1 NAT10 OGT PRPF6 PSMF1 PTBP3 SF3B4 SFPQ SMU1 SNRPB SNRPN TRAPPC6A TXNL4A WBP11 ZNHIT2	23 interacting genes: ARL4D BAG4 CD2BP2 CEP55 CFTR CTBP1 DMRTB1 EIF4ENIF1 EXOSC8 FBL FOXP1 GEMIN2 GTF2I KEAP1 LRIF1 MAFG RBFOX1 RBPMS SH3GL3 SHANK3 SNRPA TFIP11 TP53
Entrez ID		10421	6638
HPRD ID		05127	01653
Ensembl ID		ENSG00000169217	ENSG00000128739
Uniprot IDs		A0A024QZC1 O95400	P63162 X5DP00
PDB IDs		1GYF 1L2Z 1SYX 4BWS 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8RC0	5MF9 8TBP
GO Terms Enriched among Interactors		MRNA Metabolic Process MRNA Processing RNA Splicing RNA Processing MRNA Splicing, Via Spliceosome U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions U5 SnRNP RNA Metabolic Process U4/U6 X U5 Tri-snRNP Complex Spliceosomal Complex Assembly Nucleic Acid Metabolic Process Spliceosomal Complex SnRNP Binding U2 SnRNP Nucleobase-containing Compound Metabolic Process Nucleoplasm RNA Binding Negative Regulation Of Proteasomal Protein Catabolic Process U4 SnRNP Protein-containing Complex Assembly Macromolecule Metabolic Process Protein-RNA Complex Assembly Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Small Nuclear Ribonucleoprotein Complex Catalytic Step 2 Spliceosome U2-type Prespliceosome Protein-containing Complex Organization U1 SnRNP Precatalytic Spliceosome Sin3-type Complex Telomerase Holoenzyme Complex U2-type Prespliceosome Assembly U12-type Spliceosomal Complex Negative Regulation Of Protein Catabolic Process U2-type Spliceosomal Complex Negative Regulation Of Proteolysis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly TRNA Acetylation MRNA N-acetyltransferase Activity TRNA Cytidine N4-acetyltransferase Activity TRNA Wobble Cytosine Modification RRNA Acetylation Involved In Maturation Of SSU-rRNA 18S RRNA Cytidine N-acetyltransferase Activity Neuroblast Delamination Spliceosomal SnRNP Assembly Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Translational Initiation Cellular Component Assembly	Nucleus RNA Processing MRNA Metabolic Process Identical Protein Binding RNA Metabolic Process Nucleoplasm RNA Polymerase II-specific DNA-binding Transcription Factor Binding TFIID-class Transcription Factor Complex Binding RNA Splicing MRNA Processing Core Promoter Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Protein-folding Chaperone Binding