CD2BP2 and SMU1

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid)

		CD2BP2	SMU1
Description		CD2 cytoplasmic tail binding protein 2	SMU1 DNA replication regulator and spliceosomal factor
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm U5 SnRNP Cytoplasm Cytosol Nuclear Speck U4/U6 X U5 Tri-snRNP Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome
	Molecular Function	Protein Binding Ribonucleoprotein Complex Binding	Protein Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly MRNA Processing RNA Splicing	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Aspartate aminotransferase levels ( 33547301) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		22 interacting genes: ACAD11 AKNA AP2M1 CD2 CHRM3 CPSF7 CSNK2A1 LRRK1 NAT10 OGT PRPF6 PSMF1 PTBP3 SF3B4 SFPQ SMU1 SNRPB SNRPN TRAPPC6A TXNL4A WBP11 ZNHIT2	12 interacting genes: CD2BP2 CEBPA CERT1 H2BC21 LSM4 LSM8 MRFAP1 MSS51 RASSF10 TLX3 UBC YBX1
Entrez ID		10421	55234
HPRD ID		05127	11588
Ensembl ID		ENSG00000169217	ENSG00000122692
Uniprot IDs		A0A024QZC1 O95400	A0MNN4 Q2TAY7
PDB IDs		1GYF 1L2Z 1SYX 4BWS 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8RC0	5O9Z 6AHD 6Q8F 6Q8I 6Q8J 8H6K 8H6L 8QO9 8QZS
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Processing RNA Splicing RNA Processing MRNA Splicing, Via Spliceosome U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions U5 SnRNP RNA Metabolic Process U4/U6 X U5 Tri-snRNP Complex Spliceosomal Complex Assembly Nucleic Acid Metabolic Process Spliceosomal Complex SnRNP Binding U2 SnRNP Nucleobase-containing Compound Metabolic Process Nucleoplasm RNA Binding Negative Regulation Of Proteasomal Protein Catabolic Process U4 SnRNP Protein-containing Complex Assembly Macromolecule Metabolic Process Protein-RNA Complex Assembly Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Small Nuclear Ribonucleoprotein Complex Catalytic Step 2 Spliceosome U2-type Prespliceosome Protein-containing Complex Organization U1 SnRNP Precatalytic Spliceosome Sin3-type Complex Telomerase Holoenzyme Complex U2-type Prespliceosome Assembly U12-type Spliceosomal Complex Negative Regulation Of Protein Catabolic Process U2-type Spliceosomal Complex Negative Regulation Of Proteolysis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly TRNA Acetylation MRNA N-acetyltransferase Activity TRNA Cytidine N4-acetyltransferase Activity TRNA Wobble Cytosine Modification RRNA Acetylation Involved In Maturation Of SSU-rRNA 18S RRNA Cytidine N-acetyltransferase Activity Neuroblast Delamination Spliceosomal SnRNP Assembly Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Translational Initiation Cellular Component Assembly	U4/U6 X U5 Tri-snRNP Complex Nucleoplasm Lsm2-8 Complex U6 SnRNP U6 SnRNA Binding RNA Splicing MRNA Processing Spliceosomal SnRNP Assembly RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding MRNA Metabolic Process Intermembrane Sphingolipid Transfer U2-type Precatalytic Spliceosome Response To Vitamin B2 C/EBP Complex Ceramide Transfer Activity CHOP-C/EBP Complex RNA Metabolic Process P-body RNA Processing Ribonucleoprotein Complex MiRNA Transport ER To Golgi Ceramide Transport
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