MED26

Name	mediator complex subunit 26
Structure
Novel Interactors	2 novel interactors: GDF15 TRPC4AP
Interactors	8 interactors: AURKA CDK8 CTDP1 MED12 MED8 MED9 RBP1 SREBF1
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription Elongation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions
GWAS	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 )
Entrez ID	9441
HPRD ID	05437
Ensembl ID	ENSG00000105085
Uniprot IDs	O95402
PDB IDs	5ODD 6ZV3 7EMF 7ENA 7ENC 7ENJ 8GXQ 8GXS
GO Terms Enriched among Interactors ?	Mediator Complex CKM Complex Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Transcription Coregulator Activity Spindle Midzone Core Mediator Complex Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Elongation By RNA Polymerase II Response To Metformin Positive Regulation Of DNA-templated Transcription, Elongation Transcription Preinitiation Complex Assembly Positive Regulation Of Metabolic Process Nucleus Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Fatty Acid Metabolic Process Protein Modification Process TFIIF-class Transcription Factor Complex Binding Negative Regulation Of Developmental Growth Axis Elongation Involved In Somitogenesis Regulation Of Transcription Elongation By RNA Polymerase II All-trans-retinol Binding Sterol Response Element Binding Positive Regulation Of Oocyte Maturation Ubiquitin Ligase Complex Regulation Of DNA-templated Transcription Elongation Positive Regulation Of RNA Metabolic Process Spindle Assembly Involved In Female Meiosis I Germinal Vesicle Histone H3S10 Kinase Activity Regulation Of Ketone Metabolic Process Regulation Of Heart Rate By Chemical Signal Positive Regulation Of Lipid Metabolic Process Developmental Growth Involved In Morphogenesis GDF15-GFRAL Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Vitamin A Metabolic Process Retinoic Acid Biosynthetic Process Positive Regulation Of Small Molecule Metabolic Process Mitotic Cell Cycle Phase Transition