MED25 and RUSC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MED25	RUSC1
Description		mediator complex subunit 25	RUN and SH3 domain containing 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Mediator Complex Core Mediator Complex	Nucleus Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Cytoskeleton Microtubule Postsynaptic Density Microtubule Cytoskeleton Cytoplasmic Vesicle Synapse
	Molecular Function	Transcription Coactivator Binding Protein Binding Nuclear Retinoic Acid Receptor Binding Nuclear Retinoid X Receptor Binding	Actin Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Mediator Complex Assembly	Protein Polyubiquitination
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Blood trace element (Se levels) ( 23720494)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		38 interacting genes: CDK8 CREBBP CTDP1 CYSRT1 ESRP1 EYA2 FAM168B HCFC1 HGS KLHL12 KRTAP6-1 KRTAP6-3 LASP1 MED1 MED15 MED6 MED8 MED9 NCKIPSD NR3C1 ODAM OXER1 PEF1 PLEKHB2 RARA RORB RUSC1 RXRA SENP3 SERTAD3 SREBF1 STAT5B TFG THRA TLE5 USP54 WWOX WWP2	92 interacting genes: ABHD11 ABHD5 ABI2 AIRIM AKAP8L ANKS1A APP ATP6V0D2 BPIFA1 CCDC120 CCDC57 CCHCR1 CCNC CDKN2B CMTM6 CREM CRYBA2 CTAG1A CTAG1B DMRT3 DOK6 DTX2 DVL2 EXOC8 EXOSC8 FAM9B FNDC3B GCM2 HMG20A HNRNPF INSC KCTD9 KRTAP19-1 KRTAP19-5 KRTAP6-2 KRTAP8-1 LIMS3 LIMS4 LMO2 MAGEA3 MAGEA6 MAGED1 MED25 MEIS2 MISP MOAP1 MORN3 MYOZ3 N4BP3 NICN1 NTAQ1 NTRK1 NUDT22 OIP5 P4HA3 PFDN5 PIK3R3 PLA2G6 PM20D2 PNMA1 POLR1C PRDM14 PRR35 RBPMS SMARCB1 SMYD1 SOHLH1 SPAG8 STUB1 SUOX TBC1D25 TCHP TEKT4 TENT5B TLE5 TRAPPC6A TRIM55 TRIM63 TRIM73 TSSK3 TTC19 TTC7B UFSP1 VGLL3 WWOX WWP2 ZIC1 ZMYND12 ZNF34 ZNF620 ZNF765 ZNF77
Entrez ID		81857	23623
HPRD ID		14380	10206
Ensembl ID		ENSG00000104973	ENSG00000160753
Uniprot IDs		M0QZQ2 Q71SY5	A0A8Q3SIT1 B4DQB8 Q9BVN2
PDB IDs		2KY6 2L23 2L6U 2XNF 7EMF 7LBM 8GXQ 8GXS 8T9D	4GIW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Nuclear Receptor Activity Core Mediator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription Initiation By RNA Polymerase II Mediator Complex Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process MRNA Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II MRNA Transcription Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Metabolic Process Transcription Coregulator Activity Regulation Of Primary Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Intracellular Receptor Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription Elongation By RNA Polymerase II Nuclear Receptor-mediated Signaling Pathway Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Regulation Of Macromolecule Metabolic Process Transcription Coactivator Binding Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulator Complex Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Nucleoplasm Hormone-mediated Signaling Pathway Retinoic Acid Receptor Signaling Pathway COPII Vesicle Coating Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-templated Transcription	Protein Binding
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