PRKAR1B and INPP5J

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRKAR1B	INPP5J
Description		protein kinase cAMP-dependent type I regulatory subunit beta	inositol polyphosphate-5-phosphatase J
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Multivesicular Body Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane Synapse Ciliary Base Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Postsynapse Glutamatergic Synapse	Ruffle Cytoplasm Cytosol Plasma Membrane Growth Cone Neuron Projection Dendritic Shaft Plasma Membrane Bounded Cell Projection
	Molecular Function	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity CAMP Binding Protein Kinase A Catalytic Subunit Binding	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity SH3 Domain Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Inositol Trisphosphate Phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity
	Biological Process	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Learning Or Memory Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Vesicle Cycle Negative Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Fear Response Positive Regulation Of Excitatory Postsynaptic Potential	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Negative Regulation Of Neuron Projection Development Negative Regulation Of Microtubule Polymerization Inositol Phosphate Metabolic Process Glycerolipid Metabolic Process Phosphatidylinositol Dephosphorylation
Pathways		PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Synthesis of PIPs at the plasma membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Femur bone mineral density x serum urate levels interaction ( 34046847) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Plasma free amino acid levels ( 30659259) Red blood cell count ( 27863252 32888494)	Fish- and plant-related diet ( 32066663) Gut microbiota (beta diversity) ( 27723756) Oily fish consumption ( 32066663) Pork consumption ( 32066663)
Interacting Genes		75 interacting genes: AKAP1 AKAP14 ANKS1A BAG3 BAG6 BOD1L2 CAMSAP1 CBX8 CCDC187 CDC37 CDKN1A CEP19 COX5B DACH1 DNAAF19 DTNB EEF2KMT EGFR FAM161A FAM90A1 FCHSD2 GAS2L2 GLIS2 GNL3L GOLGA1 GPKOW GUCA1A IGFN1 INPP5J KANK2 KIF5B L3MBTL2 LENG1 LNX1 MBD3 MED8 MYO15B NTAQ1 NXF1 PIK3R3 POLE4 PPP1R9A PRKAA2 PRKAR1A PRPF18 PSMG1 QRICH1 RARG RUNX1T1 SAP30BP SH2D4A SHC3 SMAD3 SMAD4 SMG9 SNW1 STK16 SYTL4 TASOR2 TEAD4 THRA TSGA10IP UACA UBC VEZF1 WNK1 WRN ZBTB16 ZMYND19 ZNF177 ZNF329 ZNF35 ZNF410 ZNF559-ZNF177 ZNF76	18 interacting genes: CDC23 CEP70 DNAJA3 EFHC2 EPS8 FXR2 GOLGA2 HSF2BP MEOX1 MEOX2 PELI1 PICK1 PRKAR1B PSME3 RINT1 TLE5 TRIM27 TRIM54
Entrez ID		5575	27124
HPRD ID		01485	07573
Ensembl ID		ENSG00000188191	ENSG00000185133
Uniprot IDs		P31321	B4DF95 B5MCL8 Q15735
PDB IDs		4DIN 4F9K
Enriched GO Terms of Interacting Partners?		Protein Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Apoptotic Signaling Pathway Ciliary Basal Body Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Protein Localization Retinoic Acid Receptor Signaling Pathway RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage SMAD Protein Complex Protein Folding Chaperone Complex Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Heteromeric SMAD Protein Complex Regulation Of Transforming Growth Factor Beta2 Production Regulation Of Macromolecule Biosynthetic Process DNA Binding Zinc Ion Binding Nuclear Speck DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Intracellular Signal Transduction DNA-binding Transcription Factor Activity In Utero Embryonic Development Regulation Of Gene Expression Chordate Embryonic Development Positive Regulation Of RNA Metabolic Process Positive Regulation Of Extracellular Matrix Assembly CAMP-dependent Protein Kinase Complex Protein Carrier Chaperone Regulation Of Vitamin D Receptor Signaling Pathway Regulation Of Primary Metabolic Process Cytoplasm Nucleus	Somite Specification Cytoplasm Segment Specification Somite Development Regulation Of Cytoskeleton Organization
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