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HSPE1 and GBP2
Number of citations of the paper that reports this interaction (PubMedID
16169070
)
0
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
HSPE1
GBP2
Description
heat shock protein family E (Hsp10) member 1
guanylate binding protein 2
Image
GO Annotations
Cellular Component
Mitochondrion
Mitochondrial Matrix
Membrane
Extracellular Exosome
Golgi Membrane
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Membrane
Cytoplasmic Vesicle Membrane
Cytoplasmic Vesicle
Perinuclear Region Of Cytoplasm
Molecular Function
RNA Binding
Protein Binding
ATP Binding
Protein Folding Chaperone
Metal Ion Binding
Unfolded Protein Binding
Protein-folding Chaperone Binding
Nucleotide Binding
GTPase Activity
Endopeptidase Inhibitor Activity
Protein Binding
GTP Binding
Hydrolase Activity
Identical Protein Binding
Protein Homodimerization Activity
Molecular Function Inhibitor Activity
Biological Process
Osteoblast Differentiation
Protein Folding
Response To Unfolded Protein
Intrinsic Apoptotic Signaling Pathway
Activation Of Innate Immune Response
Immune System Process
Immune Response
Protein Localization To Nucleus
Defense Response To Bacterium
Defense Response To Protozoan
Innate Immune Response
Symbiont Entry Into Host Cell
Defense Response To Gram-positive Bacterium
Protein Maturation
Defense Response To Virus
Cytolysis In Another Organism
Cellular Response To Lipopolysaccharide
Cellular Response To Type II Interferon
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Pyroptotic Inflammatory Response
Positive Regulation Of AIM2 Inflammasome Complex Assembly
Pathways
RHOG GTPase cycle
Mitochondrial unfolded protein response (UPRmt)
Interferon gamma signaling
Interferon alpha/beta signaling
CASP4 inflammasome assembly
Microbial factors inhibit CASP4 activity
Drugs
Phenethyl Isothiocyanate
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Schizophrenia (
25056061
29483656
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Serum metabolite levels (
33031748
)
Interacting Genes
17 interacting genes:
ALDH2
APLP1
CASP3
CRMP1
EEF1A1
ERG28
GBP2
HSPD1
LINC00632
LRIF1
NTAQ1
SAT1
SELENOM
STK3
TLE1
UNC119
ZHX1
22 interacting genes:
ANXA7
BID
BNIP3L
BTBD2
CSNK2B
FBXO7
FXR1
GADD45A
GSK3B
HSPE1
KLHL20
LSM2
MAGI1
MAPK8IP2
PAFAH1B3
PPP1R8
RPS6KA1
SAT1
SEPHS1
SERPINB9
STK3
TFG
Entrez ID
3336
2634
HPRD ID
02535
02682
Ensembl ID
ENSG00000115541
ENSG00000162645
Uniprot IDs
A0A384N6A4
P61604
P32456
Q8TCE5
PDB IDs
4PJ1
6HT7
6MRC
6MRD
8G7N
8G7O
6VKJ
7E58
7M1S
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Pyroptotic Inflammatory Response
Cytoplasm
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Positive Regulation Of Membrane Permeability
Positive Regulation Of Mitochondrial Membrane Permeability
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Mitochondrial Membrane Permeability
Mitochondrial Outer Membrane Permeabilization
Positive Regulation Of Intracellular Signal Transduction
Protein Heterodimerization Activity
Regulation Of Membrane Permeability
Regulation Of Intracellular Signal Transduction
Regulation Of Apoptotic Signaling Pathway
Protein-containing Complex Assembly
Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Hepatocyte Apoptotic Process
Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death
Negative Regulation Of Apoptotic Signaling Pathway
Protein-containing Complex Organization
Mitochondrial Membrane Organization
Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Catabolic Process
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Process
Protein Targeting To Mitochondrion
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Signal Transduction
Regulation Of Extrinsic Apoptotic Signaling Pathway
Apoptotic Signaling Pathway
Negative Regulation Of Proteolysis
Protein Phosphorylation
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Catalytic Activity
Regulation Of JNK Cascade
Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein
Presynaptic Modulation Of Chemical Synaptic Transmission
Regulation Of Microtubule Anchoring At Centrosome
Cytoplasmic Translational Initiation
Ribonuclease E Activity
Spermidine Binding
Glial Cytoplasmic Inclusion
Classical Lewy Body
Lewy Body Corona
Lewy Neurite
Type II Interferon Binding
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Autophagy
Phosphorylation
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