HSPE1 and HSPD1

Number of citations of the paper that reports this interaction (PMID 10205158)
60

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		HSPE1	HSPD1
Gene Name		heat shock 10kDa protein 1	heat shock 60kDa protein 1 (chaperonin)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Membrane Extracellular Vesicular Exosome	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Early Endosome Cytosol Plasma Membrane Coated Pit Cell Surface Membrane Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex Coated Vesicle Secretory Granule Protein Complex Lipopolysaccharide Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATP Binding Poly(A) RNA Binding Unfolded Protein Binding Chaperone Binding	Lipopolysaccharide Binding P53 Binding DNA Replication Origin Binding Single-stranded DNA Binding Double-stranded RNA Binding Protein Binding ATP Binding ATPase Activity Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Osteoblast Differentiation Protein Folding Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Unfolded Protein	B Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell 'de Novo' Protein Folding Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Unfolded Protein Viral Process Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Protein Refolding B Cell Proliferation T Cell Activation B Cell Activation Positive Regulation Of Macrophage Activation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Isotype Switching To IgG Isotypes Protein Stabilization Positive Regulation Of T Cell Activation Chaperone-mediated Protein Complex Assembly Protein Maturation
Pathways			Mitochondrial protein import
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ALDH2 APLP1 C14orf1 CASP3 CRMP1 EEF1A1 GBP2 HSPD1 LRIF1 SAT1 STK3 TLE1 UNC119 ZHX1	40 interactors: ALDH2 APP BAK1 BRCA1 CA2 CASP3 CASP9 CEP70 CLEC7A CLU DHFR ERG FHIT HIST2H2BE HSPE1 ITGA3 ITGB1 KRT31 KRT40 KRTAP10-3 KRTAP10-8 KRTAP5-9 LRRK2 LZTS2 MAPK6 NOTCH2NL NR3C1 PLG PPP2R1A PPP2R1B PRKACA PRNP RASA1 RGS20 SAMD3 SIRT3 SUMO4 TLR1 TMCC2 YWHAG
Entrez ID		3336	3329
HPRD ID		02535	00318
Ensembl ID		ENSG00000115541	ENSG00000144381
Uniprot IDs		P61604	P10809
PDB IDs
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Hippo Signaling Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of Clathrin-mediated Endocytosis B Cell Cytokine Production Isotype Switching To IgG Isotypes Cellular Response To Stimulus Execution Phase Of Apoptosis Response To Stimulus Nitrogen Compound Metabolic Process Spermidine Acetylation Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Caveolin-mediated Endocytosis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Stabilization Signaling Activation Of Cysteine-type Endopeptidase Activity Anatomical Structure Morphogenesis Cell Communication Cytokinesis, Completion Of Separation Cellular Response To Norepinephrine Stimulus Putrescine Catabolic Process Zymogen Activation Apoptotic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Programmed Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Cell Death Death Positive Regulation Of Endopeptidase Activity Oxalate Transport Regulation Of Protein Stability Regulation Of Nitrogen Compound Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Regulation Of Neurotransmitter Levels Positive Regulation Of Cellular Protein Metabolic Process Response To Xenobiotic Stimulus Positive Regulation Of Peptidase Activity Polyamine Catabolic Process 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process Response To Norepinephrine Regulation Of Cellular Protein Metabolic Process Regulation Of Caveolin-mediated Endocytosis Glial Cell Apoptotic Process	Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Cell Death Regulation Of Cell Death Death Apoptotic Process Positive Regulation Of Apoptotic Process Programmed Cell Death Developmental Process Response To Organic Substance Negative Regulation Of Signal Transduction Negative Regulation Of Protein Metabolic Process Apoptotic Signaling Pathway Response To Stimulus Negative Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Signaling Negative Regulation Of Cellular Protein Metabolic Process Cell Communication Signal Transduction Positive Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Negative Regulation Of Protein Phosphorylation Regulation Of Proteolysis Regulation Of Signal Transduction Cellular Response To Stimulus Positive Regulation Of Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Intracellular Signal Transduction Cell Differentiation Cell Cycle Process Negative Regulation Of Phosphorylation Response To Stress Mitotic Cell Cycle Phase Transition Regulation Of Protein Phosphorylation Cell Cycle Phase Transition Cell Cycle Anatomical Structure Development Regulation Of Cell Adhesion Positive Regulation Of Peptidase Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Radiation Anatomical Structure Morphogenesis Positive Regulation Of Neuron Death Regulation Of Neuron Death Response To Organic Cyclic Compound
Tagcloud ?		antimicrobials cdkn1a chelation dnaja1 epiderm exquisite gstm3 hmox1 hspa1a hspa1l hspa6 hspb5 hspd1 hsph1 icp inductively investigational metallothionein microbicidal mt2a pyrithione reconstructed reconstructs sod2 topical toxicological upregulates vanicream znpt	5d achieved complicated contributed dimerization earliest endogenous enhanced facilitated heat hsp60 ifn ikkepsilon induction interacted interacting interferon irf3 knockdown mavs mda mock phosphorylated progress protective rig sev shock tbk1
Tagcloud (Difference) ?		antimicrobials cdkn1a chelation dnaja1 epiderm exquisite gstm3 hmox1 hspa1a hspa1l hspa6 hspb5 hsph1 icp inductively investigational metallothionein microbicidal mt2a pyrithione reconstructed reconstructs sod2 topical toxicological upregulates vanicream znpt	5d achieved complicated contributed dimerization earliest endogenous enhanced facilitated heat hsp60 ifn ikkepsilon induction interacted interacting interferon irf3 knockdown mavs mda mock phosphorylated progress protective rig sev shock tbk1
Tagcloud (Intersection) ?		hspd1