AKAP11 and PRKAR2A

Number of citations of the paper that reports this interaction (PMID 10209101)
21

Data Source:
HPRD (in vitro, in vivo)

		AKAP11	PRKAR2A
Gene Name		A kinase (PRKA) anchor protein 11	protein kinase, cAMP-dependent, regulatory, type II, alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Peroxisome Microtubule Organizing Center	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion CAMP-dependent Protein Kinase Complex Membrane AMP-activated Protein Kinase Complex Extracellular Vesicular Exosome Ciliary Base
	Molecular Function	Protein Phosphatase 1 Binding Protein Kinase A Binding	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Movement Of Cell Or Subcellular Component Regulation Of Protein Kinase A Signaling Intracellular Signal Transduction	Renal Water Homeostasis Energy Reserve Metabolic Process Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Transmembrane Transport Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways			Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Hedgehog 'off' state Integration of energy metabolism Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAG and IP3 signaling CaM pathway DAP12 signaling Downstream signaling of activated FGFR DARPP-32 events Glucagon signaling in metabolic regulation Innate Immune System Signaling by PDGF PKA activation in glucagon signalling Calmodulin induced events Signalling by NGF DAP12 interactions PKA-mediated phosphorylation of CREB PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events PKA activation Factors involved in megakaryocyte development and platelet production Signaling by Overexpressed Wild-Type EGFR in Cancer Aquaporin-mediated transport Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 PKA-mediated phosphorylation of CREB Signaling by EGFR Downstream signal transduction Calmodulin induced events Signaling by Hedgehog PLC-gamma1 signalling Signaling by EGFR in Cancer PKA activation
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Bone mineral density (spine) ( 19801982)
Protein-Protein Interactions		6 interactors: GSK3B PPP1CA PPP1CC PRKAR1A PRKAR2A PRKAR2B	33 interactors: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP2 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 ARFGEF2 CBFA2T3 CFTR EZR MAP2 MYCBPAP NBEA PJA2 PPP1CB PRKX RAB32 RET RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 WASF1
Entrez ID		11215	5576
HPRD ID		05261	01484
Ensembl ID		ENSG00000023516	ENSG00000114302
Uniprot IDs		Q9UKA4	P13861 Q9BUB1
PDB IDs			2IZX 2KYG
Enriched GO Terms of Interacting Partners?		Energy Reserve Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Generation Of Precursor Metabolites And Energy Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of CAMP-dependent Protein Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Activation Of Protein Kinase A Activity Negative Regulation Of Protein Serine/threonine Kinase Activity Renal Water Homeostasis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Oxidation-reduction Process Cellular Response To Glucagon Stimulus Negative Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Water Transport Neurotrophin Signaling Pathway Negative Regulation Of Kinase Activity Fluid Transport Activation Of Phospholipase C Activity Multicellular Organismal Water Homeostasis Response To Glucagon Positive Regulation Of Phospholipase C Activity Cellular Response To Organic Substance Glycogen Metabolic Process Water Homeostasis Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Positive Regulation Of Phospholipase Activity Polysaccharide Metabolic Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Negative Regulation Of Phosphorylation Renal System Process Response To Organic Substance Cell Cycle Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Protein Transport Circadian Rhythm Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Triglyceride Catabolic Process Regulation Of Insulin Secretion Positive Regulation Of Protein Phosphorylation	Regulation Of Protein Kinase A Signaling Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Signaling Cellular Response To CAMP Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Communication Signal Transduction Regulation Of Ion Transmembrane Transporter Activity Cellular Response To Stimulus Regulation Of Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transport Response To Stimulus Protein Localization Response To Purine-containing Compound Regulation Of Membrane Repolarization Regulation Of Signal Transduction Positive Regulation Of Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transport Positive Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Cation Channel Activity Cellular Response To Organic Cyclic Compound Regulation Of Signaling Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Intracellular Signal Transduction Positive Regulation Of Protein Kinase A Signaling Regulation Of Potassium Ion Transmembrane Transport Response To CAMP Regulation Of Membrane Potential Positive Regulation Of Transport Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity SMAD Protein Complex Assembly Response To Organophosphorus Regulation Of Delayed Rectifier Potassium Channel Activity Sexual Reproduction Regulation Of Transforming Growth Factor Beta2 Production Regulation Of Potassium Ion Transport Epithelial Tube Morphogenesis Regulation Of Cation Channel Activity Regulation Of Ion Transmembrane Transport Action Potential Tube Morphogenesis Regulation Of CAMP Biosynthetic Process Regulation Of Cellular Process Response To Organic Substance Positive Regulation Of Protein Import Into Nucleus
Tagcloud ?			agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?			agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?