AKAP11 and PRKAR1A

Number of citations of the paper that reports this interaction (PMID 10864471)
23

Data Source:
HPRD (in vivo)

		AKAP11	PRKAR1A
Gene Name		A kinase (PRKA) anchor protein 11	protein kinase, cAMP-dependent, regulatory, type I, alpha
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Peroxisome Microtubule Organizing Center	Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane AMP-activated Protein Kinase Complex Neuromuscular Junction Protein Complex Ciliary Base
	Molecular Function	Protein Phosphatase 1 Binding Protein Kinase A Binding	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Movement Of Cell Or Subcellular Component Regulation Of Protein Kinase A Signaling Intracellular Signal Transduction	Mesoderm Formation Renal Water Homeostasis Energy Reserve Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Water Transport Female Meiotic Division Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Sarcomere Organization Negative Regulation Of Meiotic Nuclear Division Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Transmembrane Transport Cardiac Muscle Cell Proliferation Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways			Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Hedgehog 'off' state Integration of energy metabolism Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAG and IP3 signaling CaM pathway DAP12 signaling Downstream signaling of activated FGFR DARPP-32 events Glucagon signaling in metabolic regulation Innate Immune System Signaling by PDGF PKA activation in glucagon signalling Calmodulin induced events Signalling by NGF DAP12 interactions PKA-mediated phosphorylation of CREB PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events PKA activation Factors involved in megakaryocyte development and platelet production Signaling by Overexpressed Wild-Type EGFR in Cancer Aquaporin-mediated transport Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 PKA-mediated phosphorylation of CREB Signaling by EGFR Downstream signal transduction Calmodulin induced events Signaling by Hedgehog PLC-gamma1 signalling Signaling by EGFR in Cancer PKA activation
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Bone mineral density (spine) ( 19801982)
Protein-Protein Interactions		6 interactors: GSK3B PPP1CA PPP1CC PRKAR1A PRKAR2A PRKAR2B	40 interactors: AKAP1 AKAP10 AKAP11 AKAP4 AKAP7 ARFGEF2 BAHD1 C2orf44 C2orf88 CAPN11 CBS CCNE1 CDK2 CDK4 EGFR GRB2 HIVEP1 HLA-A ITGA4 MAPK6 MAPT MYO7A NELL2 PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PYCARD RAF1 RFC2 SET SETD7 SLC2A4 SMAD2 TAB1 WNK1 ZBED1
Entrez ID		11215	5573
HPRD ID		05261	01786
Ensembl ID		ENSG00000023516	ENSG00000108946
Uniprot IDs		Q9UKA4	B2R5T5 K7ER48 P10644 Q68DQ4
PDB IDs
Enriched GO Terms of Interacting Partners?		Energy Reserve Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Generation Of Precursor Metabolites And Energy Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of CAMP-dependent Protein Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Activation Of Protein Kinase A Activity Negative Regulation Of Protein Serine/threonine Kinase Activity Renal Water Homeostasis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Oxidation-reduction Process Cellular Response To Glucagon Stimulus Negative Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Water Transport Neurotrophin Signaling Pathway Negative Regulation Of Kinase Activity Fluid Transport Activation Of Phospholipase C Activity Multicellular Organismal Water Homeostasis Response To Glucagon Positive Regulation Of Phospholipase C Activity Cellular Response To Organic Substance Glycogen Metabolic Process Water Homeostasis Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Positive Regulation Of Phospholipase Activity Polysaccharide Metabolic Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Negative Regulation Of Phosphorylation Renal System Process Response To Organic Substance Cell Cycle Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Protein Transport Circadian Rhythm Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Triglyceride Catabolic Process Regulation Of Insulin Secretion Positive Regulation Of Protein Phosphorylation	Blood Coagulation Hemostasis Regulation Of Protein Kinase Activity Regulation Of Protein Kinase A Signaling Regulation Of Body Fluid Levels Regulation Of Kinase Activity Intracellular Signal Transduction Wound Healing Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Response To Wounding Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Movement Of Cell Or Subcellular Component Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Phosphorylation Innate Immune Response Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Regulation Of Protein Phosphorylation Response To Stress Response To Growth Factor Signal Transduction Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Enzyme Linked Receptor Protein Signaling Pathway Activation Of Protein Kinase Activity Activation Of Phospholipase C Activity Cell Motility Regulation Of Phosphorus Metabolic Process Cell Activation Positive Regulation Of Phospholipase C Activity Cellular Response To Organic Substance G1/S Transition Of Mitotic Cell Cycle Signaling Locomotion Cellular Response To Peptide Hormone Stimulus Mitotic Cell Cycle Cell Communication Cellular Response To Peptide Regulation Of Cellular Protein Metabolic Process Cell Cycle Regulation Of Catalytic Activity Positive Regulation Of Phospholipase Activity Heterochromatin Organization
Tagcloud ?			agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?			agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?