TICAM2 and IRAK4

Number of citations of the paper that reports this interaction (PMID 12721283)
20

Data Source:
HPRD (in vitro, in vivo)

		TICAM2	IRAK4
Gene Name		toll-like receptor adaptor molecule 2	interleukin-1 receptor-associated kinase 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Endosome Membrane Early Endosome Membrane Late Endosome Membrane	Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Endosome Membrane
	Molecular Function	Signal Transducer Activity Phospholipid Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Interleukin-1 Receptor Binding Protein Binding ATP Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-6 Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway TRAM-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Response To Interleukin-12 Cellular Response To Lipopolysaccharide Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Interleukin-18-mediated Signaling Pathway	Cytokine Production Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation JNK Cascade Cytokine-mediated Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Smooth Muscle Cell Proliferation
Pathways		Activated TLR4 signalling Toll-Like Receptors Cascades TRAF6 mediated induction of TAK1 complex IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade TRIF-mediated programmed cell death MyD88-independent cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Innate Immune System	Toll Like Receptor 7/8 (TLR7/8) Cascade Cytokine Signaling in Immune system Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Signaling by Interleukins Toll-Like Receptors Cascades MyD88 cascade initiated on plasma membrane Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 5 (TLR5) Cascade Toll Like Receptor 4 (TLR4) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Interleukin-1 signaling Toll Like Receptor 9 (TLR9) Cascade TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Innate Immune System
Drugs
Diseases
GWAS			Immune reponse to smallpox (secreted TNF-alpha) ( 22610502)
Protein-Protein Interactions		18 interactors: FTH1 IL1R1 IL1RAP IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF7 MEOX2 OPN1LW PIAS2 SARM1 TICAM1 TIRAP TLR3 TLR4 TRAF6	18 interactors: ARNT EIF4EBP1 HIST1H1A HIST1H1B HIST1H1C HIST1H1D HIST1H1E HIST1H1T IRAK1 MBP MYD88 PELI1 PELI2 PELI3 TBPL1 TICAM2 TIRAP TRAF6
Entrez ID		353376	51135
HPRD ID		16313	06051
Ensembl ID		ENSG00000243414	ENSG00000198001
Uniprot IDs		Q86XR7	B2RAP9 B4E359 Q69FE3 Q9NWZ3
PDB IDs			2NRU 2NRY 2O8Y 2OIB 2OIC 2OID 3MOP
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Interferon-beta Production Immune System Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Cytokine Stimulus Regulation Of I-kappaB Kinase/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Interferon-beta Production Regulation Of Immune System Process Cytokine-mediated Signaling Pathway Defense Response Cellular Response To Molecule Of Bacterial Origin Response To Cytokine Response To Other Organism Response To Bacterium Response To Biotic Stimulus Response To Lipopolysaccharide Lipopolysaccharide-mediated Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Organic Substance Response To Molecule Of Bacterial Origin Regulation Of Type I Interferon Production Regulation Of Interleukin-6 Production Regulation Of Cytokine Biosynthetic Process Cellular Response To Interleukin-1 Positive Regulation Of Interferon-alpha Production Cellular Response To Organic Substance Toll-like Receptor 9 Signaling Pathway	Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Toll Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Nucleosome Assembly Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Chromatin Assembly Nucleosome Organization Toll-like Receptor 9 Signaling Pathway Response To Bacterium Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Regulation Of Cytokine Production DNA Packaging Positive Regulation Of Cytokine Production Positive Regulation Of Immune System Process Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Nucleosome Positioning Response To Other Organism Immune Response-regulating Signaling Pathway Response To Biotic Stimulus DNA Conformation Change Positive Regulation Of Intracellular Signal Transduction Response To Lipopolysaccharide Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Signal Transduction Cellular Response To Molecule Of Bacterial Origin Response To Molecule Of Bacterial Origin Regulation Of Immune System Process Defense Response Positive Regulation Of Interleukin-6 Production Positive Regulation Of Immune Response Protein Complex Assembly Regulation Of Protein Metabolic Process Regulation Of Interleukin-6 Production Innate Immune Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Lymphocyte Proliferation Response To Lipid
Tagcloud ?		advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb tlr4 tlr6 tollip tuberculin uganda	curated degeneracy degenerative districts dysbiosis emerge experimentally gi gut interactomes microbiome mtx multi nitrogenous omic pathogens picture ppi properly recollects recommendation run screens silico simulation synovial topological usage warn
Tagcloud (Difference) ?		advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb tlr4 tlr6 tollip tuberculin uganda	curated degeneracy degenerative districts dysbiosis emerge experimentally gi gut interactomes microbiome mtx multi nitrogenous omic pathogens picture ppi properly recollects recommendation run screens silico simulation synovial topological usage warn
Tagcloud (Intersection) ?