TICAM2 and IRF3

Number of citations of the paper that reports this interaction (PMID 14517278)
187

Data Source:
HPRD (in vivo)

		TICAM2	IRF3
Gene Name		toll-like receptor adaptor molecule 2	interferon regulatory factor 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Endosome Membrane Early Endosome Membrane Late Endosome Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Signal Transducer Activity Phospholipid Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-6 Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway TRAM-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Response To Interleukin-12 Cellular Response To Lipopolysaccharide Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Interleukin-18-mediated Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Apoptotic Process Cellular Response To DNA Damage Stimulus Viral Process Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Type I Interferon Biosynthetic Process Negative Regulation Of Interferon-beta Biosynthetic Process Negative Regulation Of Defense Response To Virus By Host Positive Regulation Of Cytokine Secretion Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To DsRNA Macrophage Apoptotic Process Programmed Necrotic Cell Death
Pathways		Activated TLR4 signalling Toll-Like Receptors Cascades TRAF6 mediated induction of TAK1 complex IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade TRIF-mediated programmed cell death MyD88-independent cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Innate Immune System	Negative regulators of RIG-I/MDA5 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Interferon gamma signaling Activated TLR4 signalling TRAF3-dependent IRF activation pathway ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN STING mediated induction of host immune responses Interferon alpha/beta signaling Innate Immune System ISG15 antiviral mechanism TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Interferon Signaling Cytokine Signaling in Immune system MyD88-independent cascade Factors involved in megakaryocyte development and platelet production Antiviral mechanism by IFN-stimulated genes Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Regulation of innate immune responses to cytosolic DNA Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production TRAF6 mediated IRF7 activation IRF3-mediated induction of type I IFN
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: FTH1 IL1R1 IL1RAP IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF7 MEOX2 OPN1LW PIAS2 SARM1 TICAM1 TIRAP TLR3 TLR4 TRAF6	25 interactors: CREBBP EP300 EWSR1 GRIP1 HSP90AA1 IKBKE IRF5 IRF7 MAPK8 MAVS PEX19 PIAS4 PPIB PRDX1 RB1 RBL1 RELA SERPINB2 SGTA SMURF2 SYT1 TBK1 TICAM1 TICAM2 TOMM70A
Entrez ID		353376	3661
HPRD ID		16313	04769
Ensembl ID		ENSG00000243414	ENSG00000126456
Uniprot IDs		Q86XR7	E2GIM5 E2GIM6 E2GIM7 E2GIM8 E2GIM9 M0QYT9 Q14653
PDB IDs			1J2F 1QWT 1T2K 1ZOQ 2O61 2O6G 2PI0 3A77 3QU6
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Interferon-beta Production Immune System Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Cytokine Stimulus Regulation Of I-kappaB Kinase/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Interferon-beta Production Regulation Of Immune System Process Cytokine-mediated Signaling Pathway Defense Response Cellular Response To Molecule Of Bacterial Origin Response To Cytokine Response To Other Organism Response To Bacterium Response To Biotic Stimulus Response To Lipopolysaccharide Lipopolysaccharide-mediated Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Organic Substance Response To Molecule Of Bacterial Origin Regulation Of Type I Interferon Production Regulation Of Interleukin-6 Production Regulation Of Cytokine Biosynthetic Process Cellular Response To Interleukin-1 Positive Regulation Of Interferon-alpha Production Cellular Response To Organic Substance Toll-like Receptor 9 Signaling Pathway	Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Positive Regulation Of Interferon-beta Production Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Immune Response Regulation Of Innate Immune Response Defense Response Regulation Of Interferon-beta Production Immune Response-regulating Signaling Pathway Viral Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune System Process Positive Regulation Of Interferon-alpha Production Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Defense Response To Virus Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Immune Response Positive Regulation Of Gene Expression Response To Virus Positive Regulation Of Signal Transduction Regulation Of Immune System Process Regulation Of Gene Expression I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Response To Other Organism Signaling Response To Bacterium Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Biotic Stimulus Cell Communication Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb tlr4 tlr6 tollip tuberculin uganda	antiviral called cif coactivator composed contain creb cytomegalovirus defense establishes foreskin hcmv immediate interacts interferon interferons intrinsic isg54 latent numerous participate possess responsive shortcut stat stat1 stat2 stimulated tentatively
Tagcloud (Difference) ?		advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb tlr4 tlr6 tollip tuberculin uganda	antiviral called cif coactivator composed contain creb cytomegalovirus defense establishes foreskin hcmv immediate interacts interferon interferons intrinsic isg54 latent numerous participate possess responsive shortcut stat stat1 stat2 stimulated tentatively
Tagcloud (Intersection) ?