OGG1 and RAD1

Number of citations of the paper that reports this interaction (PubMedID 19615952)
0

Data Source:
BioGRID (pull down)

		OGG1	RAD1
Description		8-oxoguanine DNA glycosylase	RAD1 checkpoint DNA exonuclease
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Nuclear Matrix Nuclear Speck Protein-containing Complex	Nucleus Nucleoplasm Chromosome Checkpoint Clamp Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Catalytic Activity Endonuclease Activity Protein Binding Microtubule Binding Oxidized Purine Nucleobase Lesion DNA N-glycosylase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Lyase Activity Enzyme Binding Oxidized Purine DNA Binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity	Damaged DNA Binding Protein Binding Double-stranded DNA 3'-5' DNA Exonuclease Activity
	Biological Process	DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Nucleotide-excision Repair Regulation Of DNA-templated Transcription DNA Damage Response Response To Oxidative Stress Response To Radiation Cellular Response To Reactive Oxygen Species Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Depurination Depyrimidination Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Double-strand Break Repair Via Single-strand Annealing	DNA Damage Checkpoint Signaling DNA Repair DNA Damage Response Substantia Nigra Development Meiotic Recombination Checkpoint Signaling Cellular Response To Ionizing Radiation
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Displacement of DNA glycosylase by APEX1 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Defective OGG1 Substrate Binding Defective OGG1 Substrate Processing	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS			Daytime sleep phenotypes ( 27126917)
Interacting Genes		7 interacting genes: CHGB HUS1 NEDD4L PRKCA RAD1 RAD9A XRCC1	24 interacting genes: COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEN1 HUS1 HUS1B MAP1LC3B MSH2 MSH3 MSH6 NEIL1 OGG1 POLB PRKN RAD17 RAD9B RHNO1 RPA1 RPA2 SIRT6 TDG TOPBP1 WRN
Entrez ID		4968	5810
HPRD ID		03582	04400
Ensembl ID		ENSG00000114026	ENSG00000113456
Uniprot IDs		A0A9L9PXU1 E5KPM5 E5KPM6 E5KPM7 E5KPM8 E5KPM9 E5KPN0 E5KPN1 O15527	O60671
PDB IDs		1EBM 1FN7 1HU0 1KO9 1LWV 1LWW 1LWY 1M3H 1M3Q 1N39 1N3A 1N3C 1YQK 1YQL 1YQM 1YQR 2I5W 2NOB 2NOE 2NOF 2NOH 2NOI 2NOL 2NOZ 2XHI 3IH7 3KTU 5AN4 6RLW 6W0M 6W0R 6W13 7AYY 8VWT 8VWV 8VX4 8VX6 9EOZ	3A1J 3G65 3GGR 6J8Y 7Z6H 8GNN 8WU8
Enriched GO Terms of Interacting Partners?		Checkpoint Clamp Complex Cellular Response To Ionizing Radiation Double-stranded DNA 3'-5' DNA Exonuclease Activity Meiotic Cell Cycle Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Replication Checkpoint Signaling DNA Repair Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Radiation Negative Regulation Of Cell Cycle Phase Transition DNA Metabolic Process DNA Damage Response Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Damaged DNA Binding Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Enzyme Binding Oxidized DNA Binding Regulation Of Cell Cycle Response To Radiation Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Nucleoplasm Telomere Maintenance Meiotic DNA Integrity Checkpoint Signaling Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Negative Regulation Of Protein ADP-ribosylation Telomere Organization Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Alphav-beta3 Integrin-PKCalpha Complex Meiotic Recombination Checkpoint Signaling ADP-D-ribose Modification-dependent Protein Binding Telomeric DNA-containing Double Minutes Formation Negative Regulation Of Protection From Non-homologous End Joining At Telomere Negative Regulation Of Sodium Ion Import Across Plasma Membrane Protein Kinase C Signaling ERCC4-ERCC1 Complex Negative Regulation Of Telomere Maintenance In Response To DNA Damage 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Regulation Of Base-excision Repair Positive Regulation Of Caveolin-mediated Endocytosis Cellular Response To Stress Regulation Of Angiotensin-activated Signaling Pathway Sodium Ion Transport Regulation Of Cell Cycle Process	DNA Repair DNA Metabolic Process DNA Damage Response Cellular Response To Stress Base-excision Repair Double-strand Break Repair Damaged DNA Binding DNA Recombination Nucleic Acid Metabolic Process DNA Damage Checkpoint Signaling Response To Stress Recombinational Repair Nucleobase-containing Compound Metabolic Process Signal Transduction In Response To DNA Damage Site Of Double-strand Break Protein Localization To Site Of Double-strand Break Mismatch Repair Mitotic DNA Damage Checkpoint Signaling Response To Radiation Mitotic DNA Integrity Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell Cycle Phase Transition Chromosome Organization Mitotic Intra-S DNA Damage Checkpoint Signaling Nucleoplasm DNA Replication Checkpoint Signaling Negative Regulation Of Cell Cycle Process Oxidized Purine DNA Binding Protein Localization To Chromosome Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Mitotic DNA Replication Checkpoint Signaling Response To Ionizing Radiation Mismatched DNA Binding Regulation Of Cell Cycle Process Response To UV Single Guanine Insertion Binding Chromosome, Telomeric Region Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Telomere Maintenance Chromatin-protein Adaptor Activity Guanine/thymine Mispair Binding Nucleotide-excision Repair Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Telomere Organization Checkpoint Clamp Complex Negative Regulation Of DNA Metabolic Process Regulation Of DNA Recombination
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