OGG1

Gene Name		8-oxoguanine DNA glycosylase
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Mitochondrion Nuclear Matrix Nuclear Speck
	Molecular Function	Damaged DNA Binding Endonuclease Activity Protein Binding Microtubule Binding Oxidized Purine Nucleobase Lesion DNA N-glycosylase Activity DNA N-glycosylase Activity 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity
	Biological Process	DNA Catabolic Process, Endonucleolytic Acute Inflammatory Response DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Nucleotide-excision Repair Regulation Of Transcription, DNA-templated Response To Oxidative Stress Aging Response To Radiation Response To Estradiol Regulation Of Protein Import Into Nucleus, Translocation Response To Drug Negative Regulation Of Apoptotic Process Depurination Response To Ethanol Response To Folic Acid Cellular Response To Cadmium Ion Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Depurination Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway Base-Excision Repair, AP Site Formation Removal of DNA patch containing abasic residue Resolution of AP sites via the single-nucleotide replacement pathway Base-free sugar-phosphate removal via the single-nucleotide replacement pathway Displacement of DNA glycosylase by APE1 Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Resolution of Abasic Sites (AP sites)
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: CHGB PRKCA XRCC1
Entrez ID		4968
HPRD ID		03582
Ensembl ID		ENSG00000114026
Uniprot IDs		E5KPM5 E5KPM6 E5KPM7 E5KPM8 E5KPM9 E5KPN0 E5KPN1 O15527
PDB IDs		1EBM 1FN7 1HU0 1KO9 1LWV 1LWW 1LWY 1M3H 1M3Q 1N39 1N3A 1N3C 1YQK 1YQL 1YQM 1YQR 2I5W 2NOB 2NOE 2NOF 2NOH 2NOI 2NOL 2NOZ 2XHI 3IH7 3KTU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Dense Core Granule Biogenesis Histone H3-T6 Phosphorylation Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Desmosome Organization Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Single Strand Break Repair Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of CAMP Biosynthetic Process Activation Of Adenylate Cyclase Activity Regulation Of Cardiac Muscle Hypertrophy Rhodopsin Mediated Signaling Pathway Regulation Of Platelet Activation Positive Regulation Of Positive Chemotaxis Negative Regulation Of CAMP Metabolic Process Regulation Of The Force Of Heart Contraction Inactivation Of MAPK Activity Mitotic Nuclear Envelope Disassembly Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Nucleotide Metabolic Process Histone Phosphorylation Nuclear Envelope Disassembly Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Lyase Activity Peptidyl-threonine Phosphorylation Activation Of Phospholipase C Activity Neutrophil Chemotaxis Positive Regulation Of Myeloid Leukocyte Differentiation Neutrophil Migration Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Endothelial Cell Migration Granulocyte Chemotaxis Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of CAMP Biosynthetic Process Base-excision Repair Regulation Of Insulin Receptor Signaling Pathway Regulation Of Glucose Import
Tagcloud ?		2h 50mg adenomas afb1 aflatoxin damaged deoxyguanosine dihydro dimethyl dmso exacerbated glycosylase guanine inconsistent initiate masses microl mycotoxin null osteosarcomas oxidatively oxidised oxo oxodg oxoguanine removes sulfoxide suspect tumourigenesis