OGG1

Description		8-oxoguanine DNA glycosylase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Nuclear Matrix Nuclear Speck Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Catalytic Activity Endonuclease Activity Protein Binding Microtubule Binding Oxidized Purine Nucleobase Lesion DNA N-glycosylase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Lyase Activity Enzyme Binding Oxidized Purine DNA Binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Nucleotide-excision Repair Regulation Of DNA-templated Transcription DNA Damage Response Response To Oxidative Stress Response To Radiation Cellular Response To Reactive Oxygen Species Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Depurination Depyrimidination Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Double-strand Break Repair Via Single-strand Annealing
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Displacement of DNA glycosylase by APEX1 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Defective OGG1 Substrate Binding Defective OGG1 Substrate Processing
Drugs
Diseases
GWAS
Interacting Genes		7 interacting genes: CHGB HUS1 NEDD4L PRKCA RAD1 RAD9A XRCC1
Entrez ID		4968
HPRD ID		03582
Ensembl ID		ENSG00000114026
Uniprot IDs		A0A9L9PXU1 E5KPM5 E5KPM6 E5KPM7 E5KPM8 E5KPM9 E5KPN0 E5KPN1 O15527
PDB IDs		1EBM 1FN7 1HU0 1KO9 1LWV 1LWW 1LWY 1M3H 1M3Q 1N39 1N3A 1N3C 1YQK 1YQL 1YQM 1YQR 2I5W 2NOB 2NOE 2NOF 2NOH 2NOI 2NOL 2NOZ 2XHI 3IH7 3KTU 5AN4 6RLW 6W0M 6W0R 6W13 7AYY 8VWT 8VWV 8VX4 8VX6 9EOZ
Enriched GO Terms of Interacting Partners?		Checkpoint Clamp Complex Cellular Response To Ionizing Radiation Double-stranded DNA 3'-5' DNA Exonuclease Activity Meiotic Cell Cycle Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Replication Checkpoint Signaling DNA Repair Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Radiation Negative Regulation Of Cell Cycle Phase Transition DNA Metabolic Process DNA Damage Response Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Damaged DNA Binding Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Enzyme Binding Oxidized DNA Binding Regulation Of Cell Cycle Response To Radiation Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Nucleoplasm Telomere Maintenance Meiotic DNA Integrity Checkpoint Signaling Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Negative Regulation Of Protein ADP-ribosylation Telomere Organization Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Alphav-beta3 Integrin-PKCalpha Complex Meiotic Recombination Checkpoint Signaling ADP-D-ribose Modification-dependent Protein Binding Telomeric DNA-containing Double Minutes Formation Negative Regulation Of Protection From Non-homologous End Joining At Telomere Negative Regulation Of Sodium Ion Import Across Plasma Membrane Protein Kinase C Signaling ERCC4-ERCC1 Complex Negative Regulation Of Telomere Maintenance In Response To DNA Damage 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Regulation Of Base-excision Repair Positive Regulation Of Caveolin-mediated Endocytosis Cellular Response To Stress Regulation Of Angiotensin-activated Signaling Pathway Sodium Ion Transport Regulation Of Cell Cycle Process
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