RHOC and RIPOR2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		RHOC	RIPOR2
Description		ras homolog family member C	RHO family interacting cell polarization regulator 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Cleavage Furrow Stereocilium Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Apical Plasma Membrane Filopodium Stereocilium Cell Projection Stereocilium Membrane Actin-based Cell Projection
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding	Protein Binding 14-3-3 Protein Binding
	Biological Process	Mitotic Cytokinesis Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Protein-containing Complex Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Canonical NF-kappaB Signal Transduction Apical Junction Assembly Wound Healing, Spreading Of Cells Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Lipase Activity Skeletal Muscle Satellite Cell Migration	Chemotaxis Cell Adhesion Negative Regulation Of Cell Adhesion Muscle Organ Development Sensory Perception Of Sound Negative Regulation Of Signal Transduction Cell Differentiation Negative Regulation Of Rho Protein Signal Transduction Negative Regulation Of T Cell Proliferation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Filopodium Assembly Regulation Of Cell Cycle Positive Regulation Of Neutrophil Chemotaxis Regulation Of Mitotic Spindle Assembly Positive Regulation Of Myoblast Fusion Negative Regulation Of Establishment Of T Cell Polarity Negative Regulation Of Protein Localization To Cell Leading Edge Cellular Response To Chemokine Regulation Of Establishment Of Cell Polarity Positive Regulation Of Neutrophil Extravasation Negative Regulation Of T Cell Migration Negative Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity
Pathways		G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins RHOC GTPase cycle	Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical surface area (visual PC2) ( 32198502) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate (creatinine) ( 28452372) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Liver enzyme levels (alkaline phosphatase) ( 33972514)
Interacting Genes		8 interacting genes: ARHGAP1 CAV1 CIT DIAPH1 RIPOR2 RIPOR3 ROCK1 RTKN	6 interacting genes: MAP2K2 MTNR1B PER1 RHOA RHOC YWHAG
Entrez ID		389	9750
HPRD ID		01322	12881
Ensembl ID		ENSG00000155366	ENSG00000111913
Uniprot IDs		A0A024R0C8 P08134	A0A2R8Y7B3 A0A2R8YEE0 B7Z5J9 B7Z6D6 B7Z6U4 F5GX51 F5H029 Q9Y4F9
PDB IDs		1Z2C 2GCN 2GCO 2GCP
Enriched GO Terms of Interacting Partners?		Small GTPase Binding Rho Protein Signal Transduction Regulation Of Cytoskeleton Organization Mitotic Cytokinesis Cytoskeleton-dependent Cytokinesis Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Intracellular Signaling Cassette Negative Regulation Of Anoikis Actin Filament-based Process Regulation Of Anoikis Cell Death Apoptotic Process Programmed Cell Death Regulation Of Establishment Or Maintenance Of Cell Polarity Regulation Of Establishment Of Cell Polarity Membrane Raft Organization Cortical Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Actin-mediated Cell Contraction Regulation Of Cell Projection Assembly Regulation Of Organelle Organization Cortical Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Microtubule-based Process Inward Rectifier Potassium Channel Inhibitor Activity Actin Filament-based Movement Negative Regulation Of Establishment Of T Cell Polarity Negative Regulation Of Protein Localization To Cell Leading Edge Response To Peptide Hormone Response To Transforming Growth Factor Beta System Process Regulation Of Actin Cytoskeleton Organization Protein Serine Kinase Activity Regulation Of Cellular Component Organization Regulation Of Developmental Process Caveolar Macromolecular Signaling Complex Positive Regulation Of Myeloid Dendritic Cell Activation Rho-dependent Protein Serine/threonine Kinase Activity Septin Ring Organization Negative Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity Regulation Of T Cell Activation Signaling Receptor Binding Protein Serine/threonine Kinase Activity Negative Regulation Of Endocytic Recycling Ruffle Positive Regulation Of Cell Junction Assembly Insulin Receptor Internalization Protein Localization To Basolateral Plasma Membrane	Skeletal Muscle Satellite Cell Migration Positive Regulation Of Lipase Activity Apical Junction Assembly Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Regulation Of Signal Transduction Negative Regulation Of Intracellular Signal Transduction Wound Healing, Spreading Of Cells Regulation Of Protein Kinase Activity Regulation Of Cell Communication Regulation Of Kinase Activity Regulation Of Signaling Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Stress Fiber Assembly Cleavage Furrow Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Vasoconstriction Positive Regulation Of Actin Filament Bundle Assembly Mitotic Cytokinesis Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Focal Adhesion Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Cytoskeleton-dependent Cytokinesis Regulation Of Stress Fiber Assembly Regulation Of Phosphorus Metabolic Process Aortic Valve Formation Cell-cell Junction Assembly Positive Regulation Of Hydrolase Activity Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Cell Motility Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Positive Regulation Of Locomotion Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Communication Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Circadian Rhythm Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Protein Modification Process Beta Selection Protein Kinase C Inhibitor Activity Blood Vessel Diameter Maintenance
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