CIT and ENPP7

Data Source: HiPPIP (Novel)

		CIT	ENPP7
Name		citron rho-interacting serine/threonine kinase	ectonucleotide pyrophosphatase/phosphodiesterase 7
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Golgi Apparatus Plasma Membrane Microvillus Membrane
	Molecular Function	Nucleotide Binding Transcription Coactivator Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity SH3 Domain Binding Protein Kinase Binding PDZ Domain Binding Protein Serine/threonine Kinase Inhibitor Activity Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity	Sphingomyelin Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Mitotic Cytokinesis Nervous System Development Cell Differentiation Positive Regulation Of Cytokinesis Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Hippo Signaling Generation Of Neurons Cell Division Neuron Apoptotic Process	Lipid Metabolic Process Sphingomyelin Metabolic Process Negative Regulation Of DNA Replication Negative Regulation Of Cell Population Proliferation Lipid Digestion Positive Regulation Of Intestinal Cholesterol Absorption Glycosphingolipid Catabolic Process Fatty Acid Homeostasis Regulation Of Intestinal Lipid Absorption Positive Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Sphingomyelin Catabolic Process
Pathways		RHO GTPases activate CIT RHO GTPases activate CIT RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle	Glycosphingolipid catabolism
Drugs		Fostamatinib	None
GWAS		Mitochondrial heteroplasmy measurement ( 33731350 ) Number of sexual partners ( 30643258 ) Urgency urinary incontinence ( 25524241 )	Blood protein levels ( 30072576 ) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415 )
Novel Interactors		6 novel interactors: ABCB9 DERA ENPP7 HIP1R MLXIPL SELPLG	2 novel interactors: CIT SRC
Interacting Genes		12 interacting genes: CEBPA DISC1 DLG4 DSCAM GRIN1 GRIN2D MTNR1A RAC1 RHOA RHOB RHOC RND3	5 interacting genes: BACH2 GOLGA2 KRTAP5-9 LRRC73 MTUS2
Entrez ID		11113	339221
HPRD ID		09289	10938
Ensembl ID		ENSG00000122966	ENSG00000182156
Uniprot IDs		O14578	Q6UWV6
PDB IDs		Not available	5TCD 5UDY
GO Terms Enriched among Interactors		Actin Filament Organization Regulation Of Neuronal Synaptic Plasticity Intracellular Signaling Cassette Skeletal Muscle Satellite Cell Migration Intracellular Signal Transduction Cerebral Cortex Cell Migration Signal Transduction Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Small GTPase-mediated Signal Transduction Supramolecular Fiber Organization Telencephalon Cell Migration Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Lipase Activity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cleavage Furrow Positive Regulation Of Stress Fiber Assembly Forebrain Cell Migration Cell Adhesion Regulation Of System Process Apical Junction Assembly GTPase Activity GTP Binding Dendritic Spine Glutamatergic Synapse Negative Regulation Of Oxidative Phosphorylation Synapse Protein-containing Complex Binding Glutamate Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission NMDA Glutamate Receptor Activity Glutamate Binding Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Multicellular Organismal Process Regulation Of Actin Filament-based Process Negative Regulation Of Cellular Respiration NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Synaptic Membrane Mitotic Cytokinesis Excitatory Chemical Synaptic Transmission Positive Regulation Of Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Regulation Of Synaptic Transmission, Glutamatergic	Negative Regulation Of Hippo Signaling