CIT and ABCB9

Data Source: HiPPIP (Novel)

		CIT	ABCB9
Name		citron rho-interacting serine/threonine kinase	ATP binding cassette subfamily B member 9
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Lysosome Lysosomal Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nucleotide Binding Transcription Coactivator Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity SH3 Domain Binding Protein Kinase Binding PDZ Domain Binding Protein Serine/threonine Kinase Inhibitor Activity Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Binding ATP Binding ABC-type Oligopeptide Transporter Activity ABC-type Peptide Transporter Activity ATP Hydrolysis Activity Transmembrane Transporter Activity Protein Homodimerization Activity ABC-type Transporter Activity
	Biological Process	Mitotic Cell Cycle Mitotic Cytokinesis Nervous System Development Cell Differentiation Positive Regulation Of Cytokinesis Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Hippo Signaling Generation Of Neurons Cell Division Neuron Apoptotic Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Metabolic Process Protein Transport Peptide Transport Oligopeptide Transmembrane Transport Transmembrane Transport
Pathways		RHO GTPases activate CIT RHO GTPases activate CIT RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle	ABC-family proteins mediated transport
Drugs		Fostamatinib	None
GWAS		Mitochondrial heteroplasmy measurement ( 33731350 ) Number of sexual partners ( 30643258 ) Urgency urinary incontinence ( 25524241 )	A body shape index ( 34021172 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Brain morphology (MOSTest) ( 32665545 ) Hip circumference adjusted for BMI ( 34021172 ) Platelet count ( 21507922 ) Schizophrenia ( 23974872 25056061 28991256 29483656 ) Tourette syndrome ( 30818990 ) Triiodothyronine levels and thyroxine levels ( 30843173 ) Type 2 diabetes ( 28869590 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226 )
Novel Interactors		6 novel interactors: ABCB9 DERA ENPP7 HIP1R MLXIPL SELPLG	1 novel interactors: CIT
Interacting Genes		12 interacting genes: CEBPA DISC1 DLG4 DSCAM GRIN1 GRIN2D MTNR1A RAC1 RHOA RHOB RHOC RND3	None recorded
Entrez ID		11113	23457
HPRD ID		09289	09262
Ensembl ID		ENSG00000122966	ENSG00000150967
Uniprot IDs		O14578	Q9NP78
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Actin Filament Organization Regulation Of Neuronal Synaptic Plasticity Intracellular Signaling Cassette Skeletal Muscle Satellite Cell Migration Intracellular Signal Transduction Cerebral Cortex Cell Migration Signal Transduction Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Small GTPase-mediated Signal Transduction Supramolecular Fiber Organization Telencephalon Cell Migration Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Lipase Activity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cleavage Furrow Positive Regulation Of Stress Fiber Assembly Forebrain Cell Migration Cell Adhesion Regulation Of System Process Apical Junction Assembly GTPase Activity GTP Binding Dendritic Spine Glutamatergic Synapse Negative Regulation Of Oxidative Phosphorylation Synapse Protein-containing Complex Binding Glutamate Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission NMDA Glutamate Receptor Activity Glutamate Binding Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Multicellular Organismal Process Regulation Of Actin Filament-based Process Negative Regulation Of Cellular Respiration NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Synaptic Membrane Mitotic Cytokinesis Excitatory Chemical Synaptic Transmission Positive Regulation Of Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Regulation Of Synaptic Transmission, Glutamatergic	Mitotic Cytokinesis Cytoskeleton-dependent Cytokinesis Positive Regulation Of Cytokinesis Regulation Of Hippo Signaling Regulation Of Cytokinesis Negative Regulation Of Hippo Signaling Neuron Apoptotic Process Scaffold Protein Binding Protein Serine/threonine Kinase Inhibitor Activity Transcription Coactivator Binding Neurogenesis PDZ Domain Binding Generation Of Neurons Positive Regulation Of Cell Division SH3 Domain Binding Mitotic Cell Cycle Regulation Of Cell Division