RHOC and CIT

Number of citations of the paper that reports this interaction (PMID 8543060)
39

Data Source:
HPRD (in vitro, two hybrid)

		RHOC	CIT
Gene Name		ras homolog family member C	citron rho-interacting serine/threonine kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Cleavage Furrow Extracellular Vesicular Exosome	Ruffle Vacuole Plasma Membrane Actin Cytoskeleton Membrane Golgi Cisterna Neuronal Cell Body
	Molecular Function	Signal Transducer Activity Protein Binding GTP Binding	Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding Rho GTPase Binding SH3 Domain Binding PDZ Domain Binding Metal Ion Binding
	Biological Process	Cytokinesis Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apical Junction Assembly Wound Healing, Spreading Of Cells Regulation Of Small GTPase Mediated Signal Transduction Skeletal Muscle Satellite Cell Migration	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Cytokinesis Protein Phosphorylation Golgi Organization Mitotic Nuclear Division Metaphase/anaphase Transition Of Mitotic Cell Cycle Spermatogenesis Regulation Of Actin Polymerization Or Depolymerization Dendrite Development Positive Regulation Of Cytokinesis Intracellular Signal Transduction Generation Of Neurons Negative Regulation Of Dendrite Morphogenesis Regulation Of Catalytic Activity
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Axon guidance Semaphorin interactions Signaling by Rho GTPases G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ARHGAP1 CAV1 CIT DIAPH1 FAM65B ROCK1 RTKN	9 interactors: DISC1 DLG4 GRIN1 GRIN2D RAC1 RHOA RHOB RHOC RND3
Entrez ID		389	11113
HPRD ID		01322	09289
Ensembl ID		ENSG00000155366	ENSG00000122966
Uniprot IDs		P08134	O14578
PDB IDs		1Z2C 2GCN 2GCO 2GCP
Enriched GO Terms of Interacting Partners?		Rho Protein Signal Transduction Ras Protein Signal Transduction Intracellular Signal Transduction Regulation Of Actin Filament-based Process Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Membrane Repolarization During Action Potential Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Nitric Oxide Homeostasis Regulation Of Epithelial Cell Differentiation Regulation Of Cellular Component Movement Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Inward Rectifier Potassium Channel Activity Sensory Perception Of Sound Regulation Of Ion Homeostasis Cell Differentiation Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Pinocytosis Sensory Perception Of Mechanical Stimulus Regulation Of Cellular Component Organization Neuron Projection Development Regulation Of Calcium Ion Transport Caveolin-mediated Endocytosis Protein Localization To Basolateral Plasma Membrane Membrane To Membrane Docking Mammary Gland Involution Protein Localization To Plasma Membrane Raft Apical Constriction Leukocyte Migration Positive Regulation Of Metalloenzyme Activity Caveola Assembly Neuron Development Apoptotic Process Regulation Of Cardiac Muscle Cell Action Potential Regulation Of The Force Of Heart Contraction By Chemical Signal Protein Localization To Microtubule Programmed Cell Death Metaphase/anaphase Transition Of Mitotic Cell Cycle Negative Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Dendrite Morphogenesis Cellular Response To Stimulus System Development Cell Death Death Cellular Response To Hyperoxia Cellular Response To Histamine Regulation Of Catalytic Activity Muscle Organ Development	Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Locomotion Cell Morphogenesis Involved In Differentiation Skeletal Muscle Satellite Cell Migration Neuron Projection Development Movement Of Cell Or Subcellular Component Cell Projection Morphogenesis Generation Of Neurons Cell Part Morphogenesis Neurogenesis Neuron Development Response To External Stimulus Cell Morphogenesis Neuron Differentiation Cell Projection Organization Small GTPase Mediated Signal Transduction Signal Transduction Nervous System Development Signaling Cell Communication Regulation Of Small GTPase Mediated Signal Transduction Ephrin Receptor Signaling Pathway Cytokinesis Cellular Response To Stimulus Neuromuscular Process Cell Development Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Projection Organization Negative Regulation Of Receptor-mediated Endocytosis Cerebral Cortex Development Cytoskeleton Organization Cell Differentiation Platelet Activation Wound Healing Startle Response Actin Cytoskeleton Organization Pallium Development Cell-cell Junction Organization Regulation Of Long-term Neuronal Synaptic Plasticity Actin Filament-based Process Positive Regulation Of Excitatory Postsynaptic Membrane Potential Anatomical Structure Morphogenesis Response To Stimulus Locomotory Behavior
Tagcloud ?		addiction belongs compromised cytoskeletal epilepsy glioblastoma glioma gtpase homologs inversely limiting nononcogene p21cip1 phenotypes retaining rhoa rhob scarcity spheroid stat3 trafficking tumorigenic v14 vast vesicle waf1 xenograft xenografts	ag allograft atn bdr black bloc cadaver cold declining drop en fatality flush hematocrit immunosuppression kidneys lrd match mismatch okt3 pra predispose preservation procurement prompted recipient rejection uw yr
Tagcloud (Difference) ?		addiction belongs compromised cytoskeletal epilepsy glioblastoma glioma gtpase homologs inversely limiting nononcogene p21cip1 phenotypes retaining rhoa rhob scarcity spheroid stat3 trafficking tumorigenic v14 vast vesicle waf1 xenograft xenografts	ag allograft atn bdr black bloc cadaver cold declining drop en fatality flush hematocrit immunosuppression kidneys lrd match mismatch okt3 pra predispose preservation procurement prompted recipient rejection uw yr
Tagcloud (Intersection) ?