RHOC and RIPOR3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RHOC	RIPOR3
Description		ras homolog family member C	RIPOR family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Cleavage Furrow Stereocilium Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding	Protein Binding
	Biological Process	Mitotic Cytokinesis Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Protein-containing Complex Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Canonical NF-kappaB Signal Transduction Apical Junction Assembly Wound Healing, Spreading Of Cells Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Lipase Activity Skeletal Muscle Satellite Cell Migration
Pathways		G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins RHOC GTPase cycle
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical surface area (visual PC2) ( 32198502) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate (creatinine) ( 28452372) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		8 interacting genes: ARHGAP1 CAV1 CIT DIAPH1 RIPOR2 RIPOR3 ROCK1 RTKN	5 interacting genes: CCDC125 RHOC SCML4 SHANK2 TRAF1
Entrez ID		389	140876
HPRD ID		01322	12757
Ensembl ID		ENSG00000155366	ENSG00000042062
Uniprot IDs		A0A024R0C8 P08134	A0A499FJE4 B7Z3F0 B7Z5S0 Q96MK2
PDB IDs		1Z2C 2GCN 2GCO 2GCP
Enriched GO Terms of Interacting Partners?		Small GTPase Binding Rho Protein Signal Transduction Regulation Of Cytoskeleton Organization Mitotic Cytokinesis Cytoskeleton-dependent Cytokinesis Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Intracellular Signaling Cassette Negative Regulation Of Anoikis Actin Filament-based Process Regulation Of Anoikis Cell Death Apoptotic Process Programmed Cell Death Regulation Of Establishment Or Maintenance Of Cell Polarity Regulation Of Establishment Of Cell Polarity Membrane Raft Organization Cortical Actin Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Actin-mediated Cell Contraction Regulation Of Cell Projection Assembly Regulation Of Organelle Organization Cortical Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Microtubule-based Process Inward Rectifier Potassium Channel Inhibitor Activity Actin Filament-based Movement Negative Regulation Of Establishment Of T Cell Polarity Negative Regulation Of Protein Localization To Cell Leading Edge Response To Peptide Hormone Response To Transforming Growth Factor Beta System Process Regulation Of Actin Cytoskeleton Organization Protein Serine Kinase Activity Regulation Of Cellular Component Organization Regulation Of Developmental Process Caveolar Macromolecular Signaling Complex Positive Regulation Of Myeloid Dendritic Cell Activation Rho-dependent Protein Serine/threonine Kinase Activity Septin Ring Organization Negative Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity Regulation Of T Cell Activation Signaling Receptor Binding Protein Serine/threonine Kinase Activity Negative Regulation Of Endocytic Recycling Ruffle Positive Regulation Of Cell Junction Assembly Insulin Receptor Internalization Protein Localization To Basolateral Plasma Membrane	Positive Regulation Of Hydrolase Activity Skeletal Muscle Satellite Cell Migration Regulation Of Intracellular Signal Transduction Synaptic Receptor Adaptor Activity Apical Junction Assembly Cell Junction Assembly Positive Regulation Of Lipase Activity Positive Regulation Of Catalytic Activity Regulation Of Canonical NF-kappaB Signal Transduction Thioesterase Binding Neurofilament
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