LILRB4 and INPP5D

Number of citations of the paper that reports this interaction (PMID 9422771)
2

Data Source:
HPRD (in vitro)

		LILRB4	INPP5D
Gene Name		leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	inositol polyphosphate-5-phosphatase, 145kDa
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Cytosol Membrane
	Molecular Function	Antigen Binding Receptor Activity Protein Binding	Inositol-polyphosphate 5-phosphatase Activity Protein Binding SH3 Domain Binding
	Biological Process	Immune System Process Signal Transduction Negative Regulation Of Osteoclast Differentiation	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Apoptotic Process Signal Transduction Blood Coagulation Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation T Cell Receptor Signaling Pathway Leukocyte Migration
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Downstream TCR signaling Metabolism of lipids and lipoproteins Cytokine Signaling in Immune system Inositol phosphate metabolism PECAM1 interactions Cell surface interactions at the vascular wall Synthesis of PIPs at the plasma membrane Signaling by Interleukins TCR signaling Interleukin receptor SHC signaling Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling Interleukin-2 signaling Phospholipid metabolism Interleukin-3, 5 and GM-CSF signaling PI Metabolism Adaptive Immune System
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Crohn's disease ( 22412388 23128233)
Protein-Protein Interactions		3 interactors: INPP5D PTPN11 PTPN6	40 interactors: ARAP1 CD22 CD300LF CRKL CSF1R CSF3R DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 LILRB4 LYN MET NOTCH2NL PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 XIAP ZDHHC17
Entrez ID		11006	3635
HPRD ID		11996	09033
Ensembl ID		ENSG00000186818	ENSG00000168918
Uniprot IDs		Q8NHJ6	Q92835
PDB IDs		3P2T	2YSX
Enriched GO Terms of Interacting Partners?		Abortive Mitotic Cell Cycle Leukocyte Migration Megakaryocyte Development Positive Regulation Of Cell Activation Platelet Formation Platelet Morphogenesis Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Megakaryocyte Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of B Cell Differentiation Regulation Of Lymphocyte Activation Blood Coagulation Hemostasis Dephosphorylation Immune Response-regulating Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Cell Activation Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Response To Wounding Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation T Cell Costimulation Cell Migration Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Cell Motility Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Immune Response Negative Regulation Of Lymphocyte Activation Antigen Receptor-mediated Signaling Pathway Cellular Response To Interferon-gamma Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Regulation Of Lymphocyte Differentiation Negative Regulation Of Signaling Negative Regulation Of Leukocyte Activation Response To Interferon-gamma Locomotion Peptidyl-tyrosine Dephosphorylation Immune Response Regulation Of Immune System Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Signaling Cell Communication Immune System Process Cell Migration Positive Regulation Of Signal Transduction Cell Motility Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Immune System Process Positive Regulation Of Kinase Activity Regulation Of Signal Transduction Locomotion Regulation Of Immune Response Positive Regulation Of Transferase Activity Leukocyte Migration Cytokine-mediated Signaling Pathway Regulation Of Signaling Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Response To Cytokine Response To Stimulus Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Protein Autophosphorylation Regulation Of Protein Kinase Activity Cellular Response To Cytokine Stimulus Response To Organic Substance Positive Regulation Of Protein Kinase Activity Regulation Of MAPK Cascade Regulation Of Kinase Activity Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Immune Response Regulation Of Phosphorylation Defense Response Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of MAPK Cascade Cellular Response To Peptide
Tagcloud ?		atp6v0d2 ctsk gcgr gpnmb granuloma instillation intratracheal lpo marco mmp12 mmp7 mreg mt3 nanotube nanotubes padi1 persistence persistently rnase9 slc26a4 spp1 subchronic suspensions swcnt swcnts tnfsf4 toxicological trem2 upregulated	cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf
Tagcloud (Difference) ?		atp6v0d2 ctsk gcgr gpnmb granuloma instillation intratracheal lpo marco mmp12 mmp7 mreg mt3 nanotube nanotubes padi1 persistence persistently rnase9 slc26a4 spp1 subchronic suspensions swcnt swcnts tnfsf4 toxicological trem2 upregulated	cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf
Tagcloud (Intersection) ?