LILRB4

Description		leukocyte immunoglobulin like receptor B4
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GO Annotations	Cellular Component	Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Extracellular Exosome
	Molecular Function	Fibronectin Binding Protein Binding Protein Phosphatase Binding Protein Tyrosine Kinase Inhibitor Activity Transmembrane Receptor Protein Tyrosine Kinase Inhibitor Activity Signaling Receptor Inhibitor Activity Inhibitory MHC Class I Receptor Activity Apolipoprotein Binding
	Biological Process	Adaptive Immune Response Immune System Process Tolerance Induction Positive Regulation Of T Cell Anergy Negative Regulation Of T Cell Cytokine Production Immune Response-regulating Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Receptor Internalization Negative Regulation Of Chemokine Production Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-5 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of T Cell Proliferation Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Negative Regulation Of MAPK Cascade Negative Regulation Of Cytotoxic T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of IP-10 Production Interleukin-10-mediated Signaling Pathway Negative Regulation Of Monocyte Activation Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of MiRNA Transcription Negative Regulation Of T Cell Costimulation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353) Inflammatory bowel disease ( 23128233) Response to platinum-based chemotherapy (carboplatin) ( 21844884)
Interacting Genes		3 interacting genes: INPP5D PTPN11 PTPN6
Entrez ID		11006
HPRD ID		11996
Ensembl ID		ENSG00000186818
Uniprot IDs		A0A0A0MS20 A0A0A0MSZ8 A0A0G2JNL1 A0A8Q3SHR1 A8MUE1 Q8NHJ6
PDB IDs		3P2T 6K7O
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Leukocyte Proliferation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Dephosphorylation Negative Regulation Of Neutrophil Activation Negative Regulation Of Lymphocyte Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell Activation Regulation Of Mononuclear Cell Proliferation Regulation Of Leukocyte Proliferation Peptidyl-tyrosine Dephosphorylation Platelet Formation Megakaryocyte Development Positive Regulation Of Lymphocyte Activation Negative Regulation Of Cytokine Production Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Immune Effector Process Positive Regulation Of Cell Activation Regulation Of B Cell Differentiation Natural Killer Cell Mediated Cytotoxicity Regulation Of Innate Immune Response Natural Killer Cell Mediated Immunity Regulation Of Type I Interferon-mediated Signaling Pathway T Cell Costimulation Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Interleukin-6 Production Regulation Of Lymphocyte Activation Negative Regulation Of Immune System Process Myeloid Cell Development Regulation Of Cell Activation Negative Regulation Of T Cell Proliferation Leukocyte Mediated Cytotoxicity Negative Regulation Of Cell Population Proliferation Protein Dephosphorylation Cell Adhesion Molecule Binding Protein Tyrosine Phosphatase Activity Negative Regulation Of Innate Immune Response Regulation Of Cytokine Production Regulation Of Defense Response T Cell Receptor Signaling Pathway SH3 Domain Binding Lymphocyte Mediated Immunity Negative Regulation Of Developmental Process Regulation Of Immune Response Regulation Of B Cell Activation
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