HACL2 and ECT2

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid)

		HACL2	ECT2
Description		2-hydroxyacyl-CoA lyase 2	epithelial cell transforming 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Acetolactate Synthase Complex Membrane	Nucleus Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Cell-cell Junction Bicellular Tight Junction Cell Cortex Nuclear Body Midbody Cleavage Furrow Anchoring Junction Mitotic Spindle Centralspindlin Complex
	Molecular Function	Magnesium Ion Binding Catalytic Activity Acetolactate Synthase Activity Protein Binding Lyase Activity Thiamine Pyrophosphate Binding Metal Ion Binding Flavin Adenine Dinucleotide Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity
	Biological Process	Fatty Acid Alpha-oxidation Lipid Metabolic Process Fatty Acid Metabolic Process	Mitotic Cytokinesis Cell Morphogenesis Nervous System Development Protein Transport Cell Differentiation Activation Of Protein Kinase Activity Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Bicellular Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Activation Of GTPase Activity Positive Regulation Of Mitotic Cytokinetic Process Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly
Pathways			NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Red cell distribution width ( 32888494)
Interacting Genes		5 interacting genes: ATXN1 CEP76 ECT2 TOM1 XRCC6	39 interacting genes: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 CSTB EIF4A2 EIF5B ELOC ERAL1 F2RL2 FANCM GGN HACL2 KLHL20 LAMTOR5 MBD1 MT-CO2 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 SRPK2 THAP11 UBB USP7 VDAC2
Entrez ID		10994	1894
HPRD ID		16152	11860
Ensembl ID		ENSG00000105135	ENSG00000114346
Uniprot IDs		A1L0T0 M0R026	Q9H8V3
PDB IDs			3L46 4N40 6L30
Enriched GO Terms of Interacting Partners?		Centralspindlin Complex Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Cellular Response To Radiation Response To Radiation Response To Ionizing Radiation Cellular Response To Ionizing Radiation Cellular Response To Chemical Stress Positive Regulation Of Cell Differentiation Regulation Of Organelle Organization Positive Regulation Of Protein Phosphorylation Cytosol Cellular Response To X-ray Double-strand Break Repair Via Classical Nonhomologous End Joining Hyperosmotic Salinity Response DNA End Binding Cellular Hyperosmotic Salinity Response Nuclear Telomere Cap Complex DNA-dependent Protein Kinase-DNA Ligase 4 Complex 5'-deoxyribose-5-phosphate Lyase Activity Cellular Response To Salt Stress Protein-containing Complex DNA-dependent Protein Kinase Complex Ku70:Ku80 Complex Double-stranded Telomeric DNA Binding Nonhomologous End Joining Complex Poly(G) Binding POZ Domain Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Clathrin Heavy Chain Binding Substrate Localization To Autophagosome Myosin VI Binding Regulation Of Endosome Organization Positive Regulation Of Autophagosome Maturation Nuclear Inclusion Body Positive Regulation Of Mitotic Cytokinesis Regulation Of Mitotic Cytokinesis Positive Regulation Of Developmental Process Autophagosome-lysosome Fusion Regulation Of Autophagosome Maturation Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Cellular Hyperosmotic Response	Cytosol Positive Regulation Of Protein Monoubiquitination Regulation Of Protein Monoubiquitination
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