HACL2 and CEP76

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		HACL2	CEP76
Description		2-hydroxyacyl-CoA lyase 2	centrosomal protein 76
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Acetolactate Synthase Complex Membrane	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Protein-containing Complex
	Molecular Function	Magnesium Ion Binding Catalytic Activity Acetolactate Synthase Activity Protein Binding Lyase Activity Thiamine Pyrophosphate Binding Metal Ion Binding Flavin Adenine Dinucleotide Binding	Protein Binding
	Biological Process	Fatty Acid Alpha-oxidation Lipid Metabolic Process Fatty Acid Metabolic Process	Regulation Of Centriole Replication
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS
Interacting Genes		5 interacting genes: ATXN1 CEP76 ECT2 TOM1 XRCC6	105 interacting genes: AKAP7 AKT1 ANKRD36 ASH2L BANP C22orf39 CABP5 CACNB3 CAPN3 CAVIN3 CCDC92 CCNK CDK18 CENPI CIRSR COIL CRYBA4 CSNK1G1 CUTC CWF19L2 DCTD DDX6 DEAF1 DMTN DVL3 DZIP1L EAF1 EIF1AD EP400P1 ERCC3 FAM90A1 GDAP2 GFAP GORASP2 HACL2 HSF2 HSPB7 IQUB KDM1A KDM4D KIAA1143 KIFBP KLHDC4 L3MBTL2 LATS1 LNX1 MAGEA11 MBD3 MFAP1 MISP MLH1 MYOZ1 NEK6 NFYC NHLRC2 NME5 PAICS PARD6B PATZ1 PDGFRB PDRG1 PDZD4 PDZD7 PIN1 PKP1 PLA2G6 PLCB1 POM121 RADIL RALGPS1 RBM41 RIPPLY3 RNF128 RPL9 SALL2 SCNM1 SH2D4A SINHCAF SMG9 SPG21 STK26 SUOX TBC1D27P TCEA2 TCEANC TCF19 TFAP2D THRA TOB2 TSPOAP1 TSSC4 TTC21A TTLL10 TUFT1 TXNDC9 VEZF1 WDFY3 YY1 ZBTB24 ZBTB4 ZMAT2 ZNF185 ZNF653 ZNF76 ZNF85
Entrez ID		10994	79959
HPRD ID		16152	12694
Ensembl ID		ENSG00000105135	ENSG00000101624
Uniprot IDs		A1L0T0 M0R026	B4DP81 Q8TAP6
PDB IDs
Enriched GO Terms of Interacting Partners?		Centralspindlin Complex Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Cellular Response To Radiation Response To Radiation Response To Ionizing Radiation Cellular Response To Ionizing Radiation Cellular Response To Chemical Stress Positive Regulation Of Cell Differentiation Regulation Of Organelle Organization Positive Regulation Of Protein Phosphorylation Cytosol Cellular Response To X-ray Double-strand Break Repair Via Classical Nonhomologous End Joining Hyperosmotic Salinity Response DNA End Binding Cellular Hyperosmotic Salinity Response Nuclear Telomere Cap Complex DNA-dependent Protein Kinase-DNA Ligase 4 Complex 5'-deoxyribose-5-phosphate Lyase Activity Cellular Response To Salt Stress Protein-containing Complex DNA-dependent Protein Kinase Complex Ku70:Ku80 Complex Double-stranded Telomeric DNA Binding Nonhomologous End Joining Complex Poly(G) Binding POZ Domain Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Clathrin Heavy Chain Binding Substrate Localization To Autophagosome Myosin VI Binding Regulation Of Endosome Organization Positive Regulation Of Autophagosome Maturation Nuclear Inclusion Body Positive Regulation Of Mitotic Cytokinesis Regulation Of Mitotic Cytokinesis Positive Regulation Of Developmental Process Autophagosome-lysosome Fusion Regulation Of Autophagosome Maturation Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Cellular Hyperosmotic Response	Protein Binding Nucleus
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