KDELR1 and ARFGAP1

Number of citations of the paper that reports this interaction (PubMedID 9405360)
51

Data Source:
HPRD (in vitro, in vivo)

		KDELR1	ARFGAP1
Description		KDEL endoplasmic reticulum protein retention receptor 1	ARF GTPase activating protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Membrane Transport Vesicle COPI-coated Vesicle Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Synapse
	Molecular Function	KDEL Sequence Binding Protein Binding ER Retention Sequence Binding	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Protein Retention In ER Lumen Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Vesicle-mediated Transport T Cell Differentiation T Cell Apoptotic Process	Protein Transport Vesicle-mediated Transport Regulation Of Endocytosis Regulation Of ARF Protein Signal Transduction
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Clathrin-mediated endocytosis
Drugs
Diseases
GWAS
Interacting Genes		12 interacting genes: ARF1 ARFGAP1 CCR9 COPB1 DLG2 DLG3 F2RL1 GPR35 KRT34 LIG4 PRKACA SEC23B	39 interacting genes: AGTR1 APOB APOC3 APOE APP ARF1 ASB10 COPA COPS5 CRYAA CSNK1D CYTH2 FOS GABARAPL1 GABARAPL2 GRN HRAS KDELR1 KRTAP10-9 KRTAP3-2 KRTAP9-2 LRRK2 MAP1LC3B MED27 PRKACB RAB23 RABGAP1L RASIP1 REEP5 RFC3 RGS2 RPL11 SLC25A21-AS1 SLC6A1 SMN1 SNCA TK1 TMED2 TRIM23
Entrez ID		10945	55738
HPRD ID		00569	06443
Ensembl ID		ENSG00000105438	ENSG00000101199
Uniprot IDs		P24390	Q53F62 Q8N6T3
PDB IDs			3DWD 3O47
Enriched GO Terms of Interacting Partners?		Intracellular Protein Transport Neuromuscular Junction Protein Transport Regulation Of Endocytosis Intracellular Protein Localization Establishment Of Protein Localization Chemokine Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Ionotropic Glutamate Receptor Binding Cellular Localization Magnesium Ion Binding Regulation Of Biological Quality Mitotic Cleavage Furrow Ingression Regulation Of Vesicle-mediated Transport Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Establishment Of Integrated Proviral Latency Protein Localization To Synapse Intracellular Transport Cleavage Furrow Ingression Retrograde Axonal Protein Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Proteinase-activated Receptor Activity Mononuclear Cell Differentiation Positive Regulation Of Phagocytosis T Cell Activation Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Chemokine-mediated Signaling Pathway Establishment Of Viral Latency Neuron Projection Protein Localization To Cell Junction Positive Regulation Of Glomerular Filtration G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Regulation Of Renin Secretion Into Blood Stream Leukocyte Differentiation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway DNA Ligase (ATP) Activity DNA Ligase IV Complex DNA Ligase Activity CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Kinase Binding Regulation Of Phagocytosis Establishment Of Localization In Cell Postsynaptic Density Membrane	Intermediate-density Lipoprotein Particle Protein-containing Complex Organization Phospholipid Binding Vesicle-mediated Transport Very-low-density Lipoprotein Particle Golgi Apparatus Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Protein-containing Complex Assembly Lipoprotein Metabolic Process Plasma Lipoprotein Particle Remodeling Cellular Response To Nitrogen Starvation Protein-containing Complex Remodeling Cellular Component Assembly Regulation Of Proteolysis Cytoplasmic Vesicle Beta-tubulin Binding Vacuole Organization Chylomicron Phosphatidylethanolamine Binding Low-density Lipoprotein Particle Chylomicron Remnant Negative Regulation Of Transport Locomotory Exploration Behavior Lipoprotein Particle Low-density Lipoprotein Particle Remodeling COPI-coated Vesicle Membrane Endocytosis Regulation Of Small Molecule Metabolic Process Regulation Of Neuronal Synaptic Plasticity Import Into Cell Cytosol Golgi Membrane Growth Cone Establishment Of Protein Localization Regulation Of Protein Catabolic Process Protein Transport Establishment Of Localization In Cell Cellular Response To Nutrient Levels Low-density Lipoprotein Particle Receptor Binding Regulation Of Long-term Neuronal Synaptic Plasticity Astrocyte Activation Involved In Immune Response Plasma Lipoprotein Particle Clearance Autophagosome Neutral Lipid Metabolic Process Cholesterol Efflux Microglial Cell Activation Positive Regulation Of Inflammatory Response Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance
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