SUOX and ZXDC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SUOX	ZXDC
Description		sulfite oxidase	ZXD family zinc finger C
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix	Nucleus
	Molecular Function	Protein Binding Sulfite Oxidase Activity Oxidoreductase Activity Heme Binding Molybdenum Ion Binding Molybdopterin Cofactor Binding Metal Ion Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Zinc Ion Binding LRR Domain Binding Metal Ion Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Sulfur Compound Metabolic Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription
Pathways		Sulfide oxidation to sulfate
Drugs		{[2-Amino-4-oxo-6,7-di(sulfanyl-κS)-3,5,5a,8,9a,10-hexahydro-4H-pyrano[3,2-g]pteridin-8-yl]methyl dihydrogenato(2-) phosphate}(dioxo)sulfanylmolybdenum
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Anorexia nervosa ( 28494655) Asthma ( 32296059 31959851 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Gastroesophageal reflux disease ( 31527586) Intelligence (MTAG) ( 29326435) Medication use (glucocorticoids) ( 31015401) Pediatric autoimmune diseases ( 26301688) Polycystic ovary syndrome ( 22885925) Refractive error ( 32231278) Type 1 diabetes ( 31152121 18198356) Vitiligo ( 22951725)	Metabolite levels ( 23823483) Pursuit maintenance gain ( 29064472)
Interacting Genes		77 interacting genes: ACOT11 BAG4 C1D CAMK2A CDCA4 CEP76 COA7 COPS8 CRX CTAG1A CTAG1B CYB5R2 DMAP1 DNAAF19 DUSP21 EIF3F ERICH4 EYA2 FAM217B FMNL2 FMR1 FNDC3B GOLGA6L9 HADHB HMG20A INCA1 ING5 ISCA2 ITGB3BP KIAA0753 KRT26 KRT27 KRT34 KRT40 LMO4 MAGEA11 MAGEB10 MBD3L1 MDFI MED28 MEIS3 MORN3 MYL7 MYO1B NUP62 PEX19 PIH1D2 POMC PRRX1 PTTG2 REL RELA RHOH RIMOC1 RINT1 RPLP1 RSKR RUSC1 SERTAD3 SGTA SH3BP5L SNF8 SOHLH1 SPC24 STAT5B STH SYNGAP1 TEX12 TRIB3 TSC1 UBQLN2 UBR2 VBP1 VPS28 ZNF143 ZNF576 ZXDC	17 interacting genes: APP ATXN1 CBR4 CIITA JTB MEPE MTDH NR1H2 NR1H3 POGZ RORA SH3GL2 SMN1 SUOX TK1 WDR5 ZMYND19
Entrez ID		6821	79364
HPRD ID		06055	14420
Ensembl ID		ENSG00000139531	ENSG00000070476
Uniprot IDs		P51687	Q2QGD7
PDB IDs		1MJ4
Enriched GO Terms of Interacting Partners?		Protein Binding Structural Constituent Of Skin Epidermis Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Cytosol Positive Regulation Of Protein Catabolic Process Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Regulation Of Nucleobase-containing Compound Metabolic Process NF-kappaB Complex Regulation Of DNA-templated Transcription Cytoplasm Regulation Of RNA Biosynthetic Process Nucleus Regulation Of Protein Catabolic Process	Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Small Molecule Metabolic Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of DNA-templated Transcription Nuclear Receptor Activity Negative Regulation Of Type II Interferon-mediated Signaling Pathway Negative Regulation Of Pinocytosis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cholesterol Storage Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Response To Type II Interferon Negative Regulation Of Macrophage Derived Foam Cell Differentiation Protein Tetramerization Regulation Of Response To Endoplasmic Reticulum Stress Sterol Homeostasis Cholesterol Homeostasis Phosphatidylcholine Acyl-chain Remodeling Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Nucleobase-containing Compound Biosynthetic Process Regulation Of Triglyceride Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Endocytosis Negative Regulation Of Lipid Storage Positive Regulation Of Triglyceride Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cholesterol Efflux Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Metabolic Process Lipid Homeostasis Positive Regulation Of Cholesterol Transport Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Inflammatory Response Negative Regulation Of Lipid Transport Positive Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Biosynthetic Process Acylglycerol Homeostasis Negative Regulation Of Inflammatory Response Triglyceride Homeostasis Regulation Of Triglyceride Metabolic Process Amyloid-beta Complex
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