PTGER4 and NISCH

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		PTGER4	NISCH
Description		prostaglandin E receptor 4	nischarin
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Intercellular Bridge Recycling Endosome
	Molecular Function	G Protein-coupled Receptor Activity Prostaglandin Receptor Activity Prostaglandin E Receptor Activity Protein Binding	Integrin Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	MAPK Cascade Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration JNK Cascade Response To Mechanical Stimulus Negative Regulation Of Integrin Activation Response To Lipid Response To Prostaglandin E T-helper Cell Differentiation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Stress Fiber Assembly Bone Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Prostaglandin E Stimulus Negative Regulation Of Eosinophil Extravasation	Apoptotic Process Rac Protein Signal Transduction Actin Cytoskeleton Organization Negative Regulation Of Cell Migration
Pathways		Prostanoid ligand receptors G alpha (s) signalling events	RAC1 GTPase cycle RND3 GTPase cycle RND2 GTPase cycle
Drugs		Dinoprostone Misoprostol Trichostatin A Limaprost Castor oil Grapiprant Rivenprost Rivenprost	Tizanidine Agmatine Moxonidine Tepotinib
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 21743469 23749187) Aspartate aminotransferase levels ( 33547301) Blood urea nitrogen levels ( 31152163) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 18587394 26278503 17684544 22936669 22412388 21102463) Gastric cancer ( 22037551 26098866) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22570697 21833088 28445677 19525953) Pediatric autoimmune diseases ( 26301688) Red blood cell count ( 32888494) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Serum urea levels ( 30808845) Type 1 diabetes ( 34127860) Ulcerative colitis ( 21297633)	A body shape index ( 34021172) Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Colon cancer ( 33632709) Distal colorectal cancer ( 33632709) General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Parkinson's disease ( 28892059) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 29483656 25056061 23974872) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		42 interacting genes: ACTN4 ACY3 ANAPC7 ATXN10 BIN1 BNIP1 CDPF1 CFAP298 CRADD CRY2 CTNND2 DPF1 DST EHMT2 FEM1A GJC2 HMOX1 HMOX2 HOPX KLC1 NISCH NUBP2 NUP153 PDLIM1 PMPCB PPP1R3F PRDX1 PSMC1 PTPRA RNF220 RTF2 SLBP SLC39A8 SND1 SPP1 ST13 SUGT1 TMEM161A TRAP1 VSTM2A WDR19 ZNF337	10 interacting genes: AR BTG3 CLIC6 IRS4 ITGA5 KLHL20 OGT PTGER4 VHL WEE2-AS1
Entrez ID		5734	11188
HPRD ID		03350	11391
Ensembl ID		ENSG00000171522	ENSG00000010322
Uniprot IDs		A0PJF5 P35408	C9J715 Q9Y2I1
PDB IDs		5YHL 5YWY 7D7M 8GCM 8GCP 8GD9 8GDA 8GDB	3P0C 8ESF
Enriched GO Terms of Interacting Partners?		Heme Oxidation Heme Oxygenase (decyclizing) Activity	Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Prostate Induction Regulation Of Programmed Cell Death Male Genitalia Morphogenesis POU Domain Binding Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Developmental Process Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Male Somatic Sex Determination Positive Regulation Of Integrin Biosynthetic Process Integrin Alpha5-beta1 Complex Alphav-beta3 Integrin-vitronectin Complex Negative Regulation Of Eosinophil Extravasation Negative Regulation Of Integrin Activation Negative Regulation Of Eosinophil Migration Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein-containing Complex Assembly Prostaglandin Receptor Activity Ubiquitin-like Ligase-substrate Adaptor Activity Regulation Of TORC1 Signaling Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Protein O-acetylglucosaminyltransferase Activity Protein K33-linked Ubiquitination Type II Interferon Binding D2 Dopamine Receptor Binding D4 Dopamine Receptor Binding D3 Dopamine Receptor Binding Pre-mRNA 5'-splice Site Binding
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