PTGER4

Gene Name		prostaglandin E receptor 4 (subtype EP4)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Prostaglandin E Receptor Activity Protein Binding
	Biological Process	Immune Response Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway JNK Cascade Response To Mechanical Stimulus Regulation Of Ossification Response To Lipopolysaccharide Negative Regulation Of Integrin Activation T-helper Cell Differentiation Negative Regulation Of Cytokine Secretion Positive Regulation Of Cytokine Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Stress Fiber Assembly Bone Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Negative Regulation Of Eosinophil Extravasation
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Prostanoid ligand receptors Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Eicosanoid ligand-binding receptors
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 21743469) Crohn's disease ( 18587394 17684544 22936669 22412388 21102463) Gastric cancer ( 22037551) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 19525953 21833088 22570697) Ulcerative colitis ( 21297633)
Protein-protein Interactions		1 interactors: FEM1A
Entrez ID		5734
HPRD ID		03350
Ensembl ID		ENSG00000171522
Uniprot IDs		A0PJF5 P35408
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Inflammatory Response Regulation Of Protein Ubiquitination Regulation Of Inflammatory Response
Tagcloud ?		appeared deltadeltact diestrus endometrium ep2 ep4 equine esr1 esr2 estrus glands immunolabeling immunoreactivity immunostaining intense localize mares myometrium pgr pr pregnancy prostaglandin qpcr quantified reproductive stroma tended weak