PTGER4 and GJC2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		PTGER4	GJC2
Description		prostaglandin E receptor 4	gap junction protein gamma 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Gap Junction Connexin Complex Membrane Myelin Sheath Anchoring Junction
	Molecular Function	G Protein-coupled Receptor Activity Prostaglandin Receptor Activity Prostaglandin E Receptor Activity Protein Binding	Gap Junction Channel Activity Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling
	Biological Process	MAPK Cascade Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration JNK Cascade Response To Mechanical Stimulus Negative Regulation Of Integrin Activation Response To Lipid Response To Prostaglandin E T-helper Cell Differentiation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Stress Fiber Assembly Bone Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Prostaglandin E Stimulus Negative Regulation Of Eosinophil Extravasation	Cell Communication Cell-cell Signaling Response To Toxic Substance Cell Communication By Electrical Coupling Transmembrane Transport
Pathways		Prostanoid ligand receptors G alpha (s) signalling events	Gap junction assembly
Drugs		Dinoprostone Misoprostol Trichostatin A Limaprost Castor oil Grapiprant Rivenprost Rivenprost
Diseases			Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 21743469 23749187) Aspartate aminotransferase levels ( 33547301) Blood urea nitrogen levels ( 31152163) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 18587394 26278503 17684544 22936669 22412388 21102463) Gastric cancer ( 22037551 26098866) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22570697 21833088 28445677 19525953) Pediatric autoimmune diseases ( 26301688) Red blood cell count ( 32888494) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Serum urea levels ( 30808845) Type 1 diabetes ( 34127860) Ulcerative colitis ( 21297633)
Interacting Genes		42 interacting genes: ACTN4 ACY3 ANAPC7 ATXN10 BIN1 BNIP1 CDPF1 CFAP298 CRADD CRY2 CTNND2 DPF1 DST EHMT2 FEM1A GJC2 HMOX1 HMOX2 HOPX KLC1 NISCH NUBP2 NUP153 PDLIM1 PMPCB PPP1R3F PRDX1 PSMC1 PTPRA RNF220 RTF2 SLBP SLC39A8 SND1 SPP1 ST13 SUGT1 TMEM161A TRAP1 VSTM2A WDR19 ZNF337	6 interacting genes: ADRB2 CHRM2 F2RL1 GPR35 LTB4R2 PTGER4
Entrez ID		5734	57165
HPRD ID		03350	10582
Ensembl ID		ENSG00000171522	ENSG00000198835
Uniprot IDs		A0PJF5 P35408	A0A654IBV7 Q5T442
PDB IDs		5YHL 5YWY 7D7M 8GCM 8GCP 8GD9 8GDA 8GDB
Enriched GO Terms of Interacting Partners?		Heme Oxidation Heme Oxygenase (decyclizing) Activity	G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein-containing Complex Disassembly Regulation Of Systemic Arterial Blood Pressure Vasodilation Clathrin-coated Endocytic Vesicle Membrane Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Signal Transduction Regulation Of Smooth Muscle Contraction Positive Regulation Of Mini Excitatory Postsynaptic Potential Plasma Membrane T Cell Activation Involved In Immune Response Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Negative Regulation Of Eosinophil Extravasation Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of System Process Beta2-adrenergic Receptor Activity Proteinase-activated Receptor Activity Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Negative Regulation Of Eosinophil Migration Leukotriene B4 Receptor Activity Lymphocyte Activation Involved In Immune Response Regulation Of Protein-containing Complex Disassembly Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Positive Regulation Of Glomerular Filtration Regulation Of Renin Secretion Into Blood Stream Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Integrin Activation Leukotriene Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Blood Vessel Diameter Maintenance Norepinephrine Binding Regulation Of Tube Size Cell Activation Involved In Immune Response Leukocyte Activation Involved In Immune Response Positive Regulation Of Killing Of Cells Of Another Organism Prostaglandin Receptor Activity Leukotriene Signaling Pathway Regulation Of Blood Pressure Regulation Of Muscle Contraction Response To Psychosocial Stress Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Activity Mature Conventional Dendritic Cell Differentiation
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