PTGER4 and PPP1R3F

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		PTGER4	PPP1R3F
Description		prostaglandin E receptor 4	protein phosphatase 1 regulatory subunit 3F
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Protein Phosphatase Type 1 Complex Membrane
	Molecular Function	G Protein-coupled Receptor Activity Prostaglandin Receptor Activity Prostaglandin E Receptor Activity Protein Binding	Protein Phosphatase 1 Binding Protein Phosphatase Binding Glycogen Binding
	Biological Process	MAPK Cascade Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration JNK Cascade Response To Mechanical Stimulus Negative Regulation Of Integrin Activation Response To Lipid Response To Prostaglandin E T-helper Cell Differentiation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Stress Fiber Assembly Bone Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Prostaglandin E Stimulus Negative Regulation Of Eosinophil Extravasation	Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen (starch) Synthase Activity
Pathways		Prostanoid ligand receptors G alpha (s) signalling events
Drugs		Dinoprostone Misoprostol Trichostatin A Limaprost Castor oil Grapiprant Rivenprost Rivenprost
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 21743469 23749187) Aspartate aminotransferase levels ( 33547301) Blood urea nitrogen levels ( 31152163) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 18587394 26278503 17684544 22936669 22412388 21102463) Gastric cancer ( 22037551 26098866) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22570697 21833088 28445677 19525953) Pediatric autoimmune diseases ( 26301688) Red blood cell count ( 32888494) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Serum urea levels ( 30808845) Type 1 diabetes ( 34127860) Ulcerative colitis ( 21297633)	Asthma ( 30929738) Asthma (childhood onset) ( 30929738)
Interacting Genes		42 interacting genes: ACTN4 ACY3 ANAPC7 ATXN10 BIN1 BNIP1 CDPF1 CFAP298 CRADD CRY2 CTNND2 DPF1 DST EHMT2 FEM1A GJC2 HMOX1 HMOX2 HOPX KLC1 NISCH NUBP2 NUP153 PDLIM1 PMPCB PPP1R3F PRDX1 PSMC1 PTPRA RNF220 RTF2 SLBP SLC39A8 SND1 SPP1 ST13 SUGT1 TMEM161A TRAP1 VSTM2A WDR19 ZNF337	5 interacting genes: AGTR1 GPR35 HTR2B PTGER4 UBE3A
Entrez ID		5734	89801
HPRD ID		03350	15170
Ensembl ID		ENSG00000171522	ENSG00000049769
Uniprot IDs		A0PJF5 P35408	Q0D2I0 Q6ZSY5
PDB IDs		5YHL 5YWY 7D7M 8GCM 8GCP 8GD9 8GDA 8GDB
Enriched GO Terms of Interacting Partners?		Heme Oxidation Heme Oxygenase (decyclizing) Activity	G Protein-coupled Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality ERK1 And ERK2 Cascade Positive Regulation Of Endothelial Cell Proliferation Angiotensin Type I Receptor Activity Animal Organ Development Negative Regulation Of Eosinophil Extravasation Sperm Entry Positive Regulation Of Golgi Lumen Acidification Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Blood Vessel Diameter Maintenance Positive Regulation Of Lipid Metabolic Process Regulation Of Tube Size Intracellular Signal Transduction Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Regulation Of Endothelial Cell Proliferation Renin-angiotensin Regulation Of Aldosterone Production Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Integrin Activation Negative Regulation Of Eosinophil Migration Regulation Of Golgi Lumen Acidification Calcium-mediated Signaling Signal Transduction Intracellular Signaling Cassette Angiotensin Type II Receptor Activity Positive Regulation Of Inflammatory Response G Protein-coupled Serotonin Receptor Complex Intestine Smooth Muscle Contraction Prostaglandin Receptor Activity Positive Regulation Of Epithelial Cell Proliferation Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Prostaglandin E Receptor Activity Positive Regulation Of Cellular PH Reduction Response To Ketone Positive Regulation Of Protein Localization To Lysosome MAPK Cascade Vascular Process In Circulatory System Regulation Of Renal Sodium Excretion C-X-C Chemokine Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Negative Regulation Of Cellular Extravasation Serotonin Binding Serotonin Receptor Signaling Pathway Prostate Gland Growth Regulation Of Lipid Metabolic Process
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