PTGER4 and VSTM2A

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		PTGER4	VSTM2A
Description		prostaglandin E receptor 4	V-set and transmembrane domain containing 2A
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Nucleus Membrane
	Molecular Function	G Protein-coupled Receptor Activity Prostaglandin Receptor Activity Prostaglandin E Receptor Activity Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	MAPK Cascade Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration JNK Cascade Response To Mechanical Stimulus Negative Regulation Of Integrin Activation Response To Lipid Response To Prostaglandin E T-helper Cell Differentiation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Stress Fiber Assembly Bone Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Prostaglandin E Stimulus Negative Regulation Of Eosinophil Extravasation	Positive Regulation Of Gene Expression Positive Regulation Of Lipid Storage Cell Differentiation Positive Regulation Of White Fat Cell Proliferation Cellular Response To BMP Stimulus Positive Regulation Of Brown Fat Cell Differentiation
Pathways		Prostanoid ligand receptors G alpha (s) signalling events
Drugs		Dinoprostone Misoprostol Trichostatin A Limaprost Castor oil Grapiprant Rivenprost Rivenprost
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 21743469 23749187) Aspartate aminotransferase levels ( 33547301) Blood urea nitrogen levels ( 31152163) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 18587394 26278503 17684544 22936669 22412388 21102463) Gastric cancer ( 22037551 26098866) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22570697 21833088 28445677 19525953) Pediatric autoimmune diseases ( 26301688) Red blood cell count ( 32888494) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Serum urea levels ( 30808845) Type 1 diabetes ( 34127860) Ulcerative colitis ( 21297633)	Adult body size ( 32376654) Cervical cancer ( 30412241) Dental caries (decayed and filled deciduous teeth) ( 31533690) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Logical memory (immediate recall) in Alzheimer's disease dementia ( 29274321) Metabolite levels ( 23823483) Waist-to-hip ratio adjusted for body mass index ( 27195708)
Interacting Genes		42 interacting genes: ACTN4 ACY3 ANAPC7 ATXN10 BIN1 BNIP1 CDPF1 CFAP298 CRADD CRY2 CTNND2 DPF1 DST EHMT2 FEM1A GJC2 HMOX1 HMOX2 HOPX KLC1 NISCH NUBP2 NUP153 PDLIM1 PMPCB PPP1R3F PRDX1 PSMC1 PTPRA RNF220 RTF2 SLBP SLC39A8 SND1 SPP1 ST13 SUGT1 TMEM161A TRAP1 VSTM2A WDR19 ZNF337	2 interacting genes: MSANTD3 PTGER4
Entrez ID		5734	222008
HPRD ID		03350	14566
Ensembl ID		ENSG00000171522	ENSG00000170419
Uniprot IDs		A0PJF5 P35408	F8W8J5 Q8TAG5
PDB IDs		5YHL 5YWY 7D7M 8GCM 8GCP 8GD9 8GDA 8GDB
Enriched GO Terms of Interacting Partners?		Heme Oxidation Heme Oxygenase (decyclizing) Activity	Negative Regulation Of Eosinophil Extravasation Negative Regulation Of Integrin Activation Negative Regulation Of Eosinophil Migration Prostaglandin Receptor Activity Prostaglandin E Receptor Activity Negative Regulation Of Cellular Extravasation Regulation Of Integrin Activation Cellular Response To Prostaglandin E Stimulus T-helper Cell Differentiation Regulation Of Cellular Extravasation Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E T Cell Differentiation Involved In Immune Response CD4-positive, Alpha-beta T Cell Differentiation ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Migration JNK Cascade CD4-positive, Alpha-beta T Cell Activation T Cell Activation Involved In Immune Response Alpha-beta T Cell Differentiation Cellular Response To Mechanical Stimulus Bone Development
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