CPLX2 and PBX3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CPLX2	PBX3
Description		complexin 2	PBX homeobox 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Dendrite SNARE Complex Cell Projection Neuronal Cell Body Terminal Bouton Perikaryon Calyx Of Held Synapse Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-3-complexin Complex Presynapse Postsynapse Glutamatergic Synapse	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	SNARE Binding Protein Binding Syntaxin-1 Binding Syntaxin Binding Calcium-dependent Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding
	Biological Process	Neurotransmitter Transport Exocytosis Vesicle Docking Involved In Exocytosis Nervous System Development Synaptic Vesicle Exocytosis Regulation Of Exocytosis Cell Differentiation Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Positive Regulation Of Synaptic Plasticity Mast Cell Degranulation Modulation Of Chemical Synaptic Transmission	Eye Development Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of DNA-templated Transcription Anterior Compartment Pattern Formation Posterior Compartment Specification Brain Development Respiratory Gaseous Exchange By Respiratory System Adult Locomotory Behavior Animal Organ Morphogenesis Dorsal Spinal Cord Development Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Neuron Development
Pathways
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 24951543) Chronotype ( 30696823) Obesity-related traits ( 23251661)	Dentures ( 31235808) Fish- and plant-related diet ( 32066663) Medication use (opioids) ( 31015401) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Pulse pressure ( 30578418) Raw vegetable consumption ( 32066663) Refractive error ( 32231278) Response to mTOR inhibitor (everolimus) ( 24009623) Sleep duration ( 30531941) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 30224653 30578418)
Interacting Genes		7 interacting genes: APP MYG1 NDRG4 PBX3 STX2 STX3 TSFM	65 interacting genes: AGTRAP ARFIP2 ARL6IP1 BIK BSND CAV3 CFTR CIDEB CMTM4 CMTM5 COQ8A CPLX2 DESI2 DGAT2L6 FADS6 FAM177A1 FKBP7 FSD2 GAD2 GBP7 HIGD1C HOXA9 HOXB8 HSD17B13 INPP5K INSYN1 ITGB3BP KRT27 KRT31 LIME1 MAGEA1 MAGEC2 MAL2 MBLAC2 MDK MEIS1 MICOS13 MTERF3 NUDT9 PKNOX1 PLIN3 PRB3 PTPN9 RABAC1 REEP5 RHBDD2 RHEX RNF186 RPRM SCAMP1 SFT2D2 SIN3A SMPD2 SYP SYPL1 TFIP11 TMCO2 TMEM196 TPD52L1 TPM3 TRAF1 TRIM44 TVP23B ZNF655 ZNHIT3
Entrez ID		10814	5090
HPRD ID		09234	15938
Ensembl ID		ENSG00000145920	ENSG00000167081
Uniprot IDs		Q6PUV4	P40426 Q5JS98 Q96AL5
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle Docking Membrane Docking Organelle Localization By Membrane Tethering Locomotory Behavior SNAP Receptor Activity SNARE Complex Amyloid-beta Complex Growth Cone Lamellipodium Visual Behavior Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning SNARE Binding Posterior Compartment Specification Anterior Compartment Pattern Formation Adult Locomotory Behavior Acetylcholine Receptor Activator Activity Associative Learning Lipoprotein Particle Positive Regulation Of Protein Import Organelle Membrane Fusion Organelle Localization Vesicle Fusion Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Organelle Fusion Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Chemotaxis Anatomical Structure Morphogenesis Adult Behavior Cellular Response To Norepinephrine Stimulus Growth Cone Positive Regulation Of Synaptic Transmission Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Membrane Fusion Compartment Pattern Specification Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation	Protein Binding
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